Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2525c

Experiment: 7H9 with Moxifloxacin 0.121 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2524c and Rv2525c are separated by 519 nucleotidesRv2525c and Rv2526 are separated by 516 nucleotidesRv2526 and Rv2527 overlap by 4 nucleotides Rv2524c: Rv2524c - Probable fatty acid synthase Fas (fatty acid synthetase), at 2,840,123 to 2,849,332 Rv2524c Rv2525c: Rv2525c - Conserved hypothetical protein. Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system., at 2,849,852 to 2,850,574 Rv2525c Rv2526: Rv2526 - Possible antitoxin VapB17, at 2,851,091 to 2,851,318 Rv2526 Rv2527: Rv2527 - Possible toxin VapC17, at 2,851,315 to 2,851,716 Rv2527 Position (kb) 2849 2850 2851Strain fitness (log2 ratio) -3 -2 -1 0 1 2 3at 2849.348 kb on - strandat 2849.562 kb on - strandat 2849.964 kb on + strand, within Rv2525cat 2849.964 kb on + strand, within Rv2525cat 2849.964 kb on + strand, within Rv2525cat 2849.964 kb on + strand, within Rv2525cat 2849.965 kb on - strand, within Rv2525cat 2850.051 kb on + strand, within Rv2525cat 2850.052 kb on - strand, within Rv2525cat 2850.052 kb on - strand, within Rv2525cat 2850.099 kb on + strand, within Rv2525cat 2850.120 kb on + strand, within Rv2525cat 2850.120 kb on + strand, within Rv2525cat 2850.120 kb on + strand, within Rv2525cat 2850.120 kb on + strand, within Rv2525cat 2850.120 kb on + strand, within Rv2525cat 2850.121 kb on - strand, within Rv2525cat 2850.121 kb on - strand, within Rv2525cat 2850.129 kb on + strand, within Rv2525cat 2850.130 kb on - strand, within Rv2525cat 2850.130 kb on - strand, within Rv2525cat 2850.130 kb on - strand, within Rv2525cat 2850.271 kb on - strand, within Rv2525cat 2850.276 kb on + strand, within Rv2525cat 2850.277 kb on - strand, within Rv2525cat 2850.381 kb on + strand, within Rv2525cat 2850.444 kb on + strand, within Rv2525cat 2850.445 kb on - strand, within Rv2525cat 2850.445 kb on - strand, within Rv2525cat 2850.713 kb on + strandat 2850.714 kb on - strandat 2850.714 kb on - strandat 2850.717 kb on - strandat 2850.732 kb on - strandat 2850.801 kb on + strandat 2850.801 kb on + strandat 2850.802 kb on - strandat 2850.851 kb on + strandat 2850.913 kb on - strandat 2850.913 kb on - strandat 2851.082 kb on + strandat 2851.098 kb on + strandat 2851.436 kb on - strand, within Rv2527at 2851.436 kb on - strand, within Rv2527at 2851.436 kb on - strand, within Rv2527at 2851.460 kb on - strand, within Rv2527at 2851.490 kb on - strand, within Rv2527at 2851.551 kb on - strand, within Rv2527

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Moxifloxacin 0.121 ug/mL
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2,849,348 - -1.3
2,849,562 - -0.7
2,849,964 + Rv2525c 0.15 -0.6
2,849,964 + Rv2525c 0.15 -0.4
2,849,964 + Rv2525c 0.15 -0.5
2,849,964 + Rv2525c 0.15 -0.8
2,849,965 - Rv2525c 0.16 -0.6
2,850,051 + Rv2525c 0.28 -0.8
2,850,052 - Rv2525c 0.28 -0.9
2,850,052 - Rv2525c 0.28 +0.6
2,850,099 + Rv2525c 0.34 -1.7
2,850,120 + Rv2525c 0.37 -1.2
2,850,120 + Rv2525c 0.37 -0.8
2,850,120 + Rv2525c 0.37 -2.3
2,850,120 + Rv2525c 0.37 -0.9
2,850,120 + Rv2525c 0.37 -1.8
2,850,121 - Rv2525c 0.37 -2.9
2,850,121 - Rv2525c 0.37 -1.0
2,850,129 + Rv2525c 0.38 -2.9
2,850,130 - Rv2525c 0.38 -1.1
2,850,130 - Rv2525c 0.38 -2.4
2,850,130 - Rv2525c 0.38 -0.9
2,850,271 - Rv2525c 0.58 -0.5
2,850,276 + Rv2525c 0.59 -1.6
2,850,277 - Rv2525c 0.59 -1.9
2,850,381 + Rv2525c 0.73 -0.6
2,850,444 + Rv2525c 0.82 -0.5
2,850,445 - Rv2525c 0.82 -1.2
2,850,445 - Rv2525c 0.82 +1.2
2,850,713 + +0.3
2,850,714 - -0.1
2,850,714 - -0.9
2,850,717 - -1.3
2,850,732 - -2.2
2,850,801 + +0.5
2,850,801 + -0.9
2,850,802 - -0.1
2,850,851 + +1.3
2,850,913 - -0.1
2,850,913 - -0.1
2,851,082 + -0.8
2,851,098 + +1.7
2,851,436 - Rv2527 0.30 +0.2
2,851,436 - Rv2527 0.30 +2.8
2,851,436 - Rv2527 0.30 +0.5
2,851,460 - Rv2527 0.36 -0.7
2,851,490 - Rv2527 0.44 -0.5
2,851,551 - Rv2527 0.59 -0.1

Or see this region's nucleotide sequence