Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2396

Experiment: 7H9 with Moxifloxacin 0.121 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2395 and Rv2395A are separated by 148 nucleotidesRv2395A and Rv2395B are separated by 111 nucleotidesRv2395B and Rv2396 are separated by 83 nucleotidesRv2396 and Rv2397c are separated by 24 nucleotides Rv2395: Rv2395 - Probable conserved integral membrane protein, at 2,690,072 to 2,692,075 Rv2395 Rv2395A: Rv2395A - Acid and phagosome regulated protein A AprA, at 2,692,224 to 2,692,439 Rv2395A Rv2395B: Rv2395B - Acid and phagosome regulated protein B AprB, at 2,692,551 to 2,692,715 Rv2395B Rv2396: Rv2396 - PE-PGRS family protein PE_PGRS41, at 2,692,799 to 2,693,884 Rv2396 Rv2397c: Rv2397c - Sulfate-transport ATP-binding protein ABC transporter CysA1, at 2,693,909 to 2,694,964 Rv2397c Position (kb) 2692 2693 2694Strain fitness (log2 ratio) -2 -1 0 1 2at 2691.861 kb on - strand, within Rv2395at 2692.714 kb on - strandat 2692.714 kb on - strandat 2692.714 kb on - strandat 2692.770 kb on + strandat 2692.770 kb on + strandat 2692.771 kb on - strandat 2692.771 kb on - strandat 2692.771 kb on - strandat 2692.771 kb on - strandat 2692.771 kb on - strandat 2692.771 kb on - strandat 2692.848 kb on - strandat 2692.848 kb on - strandat 2692.848 kb on - strandat 2692.848 kb on - strandat 2692.848 kb on - strandat 2692.848 kb on - strandat 2692.982 kb on + strand, within Rv2396at 2692.982 kb on + strand, within Rv2396at 2692.982 kb on + strand, within Rv2396at 2692.983 kb on - strand, within Rv2396at 2693.032 kb on + strand, within Rv2396at 2693.032 kb on + strand, within Rv2396at 2693.033 kb on - strand, within Rv2396at 2693.058 kb on - strand, within Rv2396at 2693.058 kb on - strand, within Rv2396at 2693.058 kb on - strand, within Rv2396at 2693.058 kb on - strand, within Rv2396at 2693.058 kb on - strand, within Rv2396at 2693.588 kb on + strand, within Rv2396at 2693.588 kb on + strand, within Rv2396at 2693.589 kb on - strand, within Rv2396at 2693.589 kb on - strand, within Rv2396at 2694.297 kb on + strand, within Rv2397c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Moxifloxacin 0.121 ug/mL
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2,691,861 - Rv2395 0.89 -0.4
2,692,714 - -0.7
2,692,714 - -0.2
2,692,714 - -0.2
2,692,770 + +0.4
2,692,770 + -0.7
2,692,771 - +0.0
2,692,771 - +0.0
2,692,771 - -2.4
2,692,771 - +1.5
2,692,771 - +1.0
2,692,771 - +1.0
2,692,848 - +1.2
2,692,848 - -0.5
2,692,848 - -2.1
2,692,848 - +1.1
2,692,848 - +0.1
2,692,848 - +0.7
2,692,982 + Rv2396 0.17 +0.4
2,692,982 + Rv2396 0.17 -0.0
2,692,982 + Rv2396 0.17 +0.2
2,692,983 - Rv2396 0.17 +0.8
2,693,032 + Rv2396 0.21 -1.2
2,693,032 + Rv2396 0.21 +0.3
2,693,033 - Rv2396 0.22 +0.5
2,693,058 - Rv2396 0.24 +0.6
2,693,058 - Rv2396 0.24 -1.2
2,693,058 - Rv2396 0.24 +0.9
2,693,058 - Rv2396 0.24 +2.0
2,693,058 - Rv2396 0.24 +0.2
2,693,588 + Rv2396 0.73 -1.7
2,693,588 + Rv2396 0.73 -1.0
2,693,589 - Rv2396 0.73 +0.2
2,693,589 - Rv2396 0.73 +1.1
2,694,297 + Rv2397c 0.37 -0.2

Or see this region's nucleotide sequence