Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1421

Experiment: 7H9 with Moxifloxacin 0.121 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1420 and Rv1421 overlap by 4 nucleotidesRv1421 and Rv1422 overlap by 4 nucleotides Rv1420: Rv1420 - Probable excinuclease ABC (subunit C-nuclease) UvrC, at 1,594,042 to 1,595,982 Rv1420 Rv1421: Rv1421 - Conserved protein, at 1,595,979 to 1,596,884 Rv1421 Rv1422: Rv1422 - Conserved hypothetical protein, at 1,596,881 to 1,597,909 Rv1422 Position (kb) 1595 1596 1597Strain fitness (log2 ratio) -1 0 1 2at 1595.759 kb on - strand, within Rv1420at 1596.105 kb on + strand, within Rv1421at 1596.400 kb on + strand, within Rv1421at 1596.710 kb on - strand, within Rv1421at 1596.753 kb on - strand, within Rv1421at 1596.783 kb on - strand, within Rv1421at 1596.960 kb on - strandat 1597.485 kb on + strand, within Rv1422at 1597.486 kb on - strand, within Rv1422at 1597.770 kb on + strand, within Rv1422

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Moxifloxacin 0.121 ug/mL
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1,595,759 - Rv1420 0.88 +0.5
1,596,105 + Rv1421 0.14 -1.4
1,596,400 + Rv1421 0.46 -1.2
1,596,710 - Rv1421 0.81 -0.3
1,596,753 - Rv1421 0.85 -0.3
1,596,783 - Rv1421 0.89 -0.2
1,596,960 - -1.2
1,597,485 + Rv1422 0.59 +2.2
1,597,486 - Rv1422 0.59 -0.5
1,597,770 + Rv1422 0.86 +0.9

Or see this region's nucleotide sequence