Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0375c

Experiment: 7H9 with Moxifloxacin 0.121 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0373c and Rv0374c overlap by 4 nucleotidesRv0374c and Rv0375c are separated by 14 nucleotidesRv0375c and Rv0376c are separated by 75 nucleotides Rv0373c: Rv0373c - Probable carbon monoxyde dehydrogenase (large chain), at 449,404 to 451,803 Rv0373c Rv0374c: Rv0374c - Probable carbon monoxyde dehydrogenase (small chain), at 451,800 to 452,279 Rv0374c Rv0375c: Rv0375c - Probable carbon monoxyde dehydrogenase (medium chain), at 452,294 to 453,154 Rv0375c Rv0376c: Rv0376c - Conserved hypothetical protein, at 453,230 to 454,372 Rv0376c Position (kb) 452 453 454Strain fitness (log2 ratio) -2 -1 0 1 2at 451.492 kb on + strand, within Rv0373cat 451.492 kb on + strand, within Rv0373cat 451.864 kb on + strand, within Rv0374cat 451.955 kb on + strand, within Rv0374cat 452.386 kb on - strand, within Rv0375cat 452.386 kb on - strand, within Rv0375cat 453.007 kb on - strand, within Rv0375cat 453.189 kb on - strandat 453.189 kb on - strandat 453.242 kb on + strandat 453.243 kb on - strandat 453.243 kb on - strandat 453.243 kb on - strandat 453.243 kb on - strandat 453.243 kb on - strandat 453.246 kb on + strandat 453.505 kb on - strand, within Rv0376cat 454.137 kb on - strand, within Rv0376c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Moxifloxacin 0.121 ug/mL
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451,492 + Rv0373c 0.87 -0.4
451,492 + Rv0373c 0.87 -0.4
451,864 + Rv0374c 0.13 +2.3
451,955 + Rv0374c 0.32 -0.9
452,386 - Rv0375c 0.11 -1.4
452,386 - Rv0375c 0.11 -0.8
453,007 - Rv0375c 0.83 -2.2
453,189 - -1.3
453,189 - +0.4
453,242 + +1.3
453,243 - -0.4
453,243 - -1.1
453,243 - -2.0
453,243 - -2.0
453,243 - -1.3
453,246 + -0.7
453,505 - Rv0376c 0.24 -1.4
454,137 - Rv0376c 0.79 -1.0

Or see this region's nucleotide sequence