Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0166

Experiment: 7H9 with Moxifloxacin 0.121 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0164 and Rv0165c are separated by 32 nucleotidesRv0165c and Rv0166 are separated by 177 nucleotidesRv0166 and Rv0167 are separated by 203 nucleotides Rv0164: Rv0164 - Conserved protein TB18.5, at 193,626 to 194,111 Rv0164 Rv0165c: Rv0165c - Probable transcriptional regulatory protein Mce1R (probably GntR-family), at 194,144 to 194,815 Rv0165c Rv0166: Rv0166 - Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase), at 194,993 to 196,657 Rv0166 Rv0167: Rv0167 - Conserved integral membrane protein YrbE1A, at 196,861 to 197,658 Rv0167 Position (kb) 194 195 196 197Strain fitness (log2 ratio) -1 0 1 2 3at 194.308 kb on - strand, within Rv0165cat 194.310 kb on + strand, within Rv0165cat 194.310 kb on + strand, within Rv0165cat 194.311 kb on - strand, within Rv0165cat 194.311 kb on - strand, within Rv0165cat 194.311 kb on - strand, within Rv0165cat 194.324 kb on - strand, within Rv0165cat 194.324 kb on - strand, within Rv0165cat 194.324 kb on - strand, within Rv0165cat 194.933 kb on + strandat 194.934 kb on - strandat 194.934 kb on - strandat 194.941 kb on - strandat 194.990 kb on + strandat 194.991 kb on - strandat 194.991 kb on - strandat 195.053 kb on + strandat 195.162 kb on + strand, within Rv0166at 195.162 kb on + strand, within Rv0166at 195.162 kb on + strand, within Rv0166at 195.245 kb on - strand, within Rv0166at 195.303 kb on + strand, within Rv0166at 195.483 kb on - strand, within Rv0166at 195.483 kb on - strand, within Rv0166at 195.492 kb on + strand, within Rv0166at 195.493 kb on - strand, within Rv0166at 195.560 kb on + strand, within Rv0166at 195.561 kb on - strand, within Rv0166at 195.641 kb on + strand, within Rv0166at 195.642 kb on - strand, within Rv0166at 195.758 kb on + strand, within Rv0166at 195.859 kb on + strand, within Rv0166at 195.860 kb on - strand, within Rv0166at 195.895 kb on - strand, within Rv0166at 196.294 kb on + strand, within Rv0166at 196.295 kb on - strand, within Rv0166at 196.316 kb on + strand, within Rv0166at 196.316 kb on + strand, within Rv0166at 196.317 kb on - strand, within Rv0166at 196.458 kb on + strand, within Rv0166at 196.458 kb on + strand, within Rv0166at 196.490 kb on + strand, within Rv0166at 196.656 kb on - strandat 196.684 kb on - strandat 196.700 kb on + strandat 196.701 kb on - strandat 196.757 kb on - strandat 197.091 kb on + strand, within Rv0167

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Moxifloxacin 0.121 ug/mL
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194,308 - Rv0165c 0.24 -0.4
194,310 + Rv0165c 0.25 -0.8
194,310 + Rv0165c 0.25 +0.3
194,311 - Rv0165c 0.25 +1.4
194,311 - Rv0165c 0.25 +0.4
194,311 - Rv0165c 0.25 +2.8
194,324 - Rv0165c 0.27 +2.4
194,324 - Rv0165c 0.27 +1.4
194,324 - Rv0165c 0.27 -0.6
194,933 + -0.3
194,934 - -0.6
194,934 - -0.1
194,941 - +0.2
194,990 + -0.8
194,991 - +0.5
194,991 - -0.1
195,053 + -0.8
195,162 + Rv0166 0.10 -0.1
195,162 + Rv0166 0.10 -0.4
195,162 + Rv0166 0.10 +0.6
195,245 - Rv0166 0.15 +0.4
195,303 + Rv0166 0.19 -0.7
195,483 - Rv0166 0.29 -0.9
195,483 - Rv0166 0.29 -0.7
195,492 + Rv0166 0.30 +1.4
195,493 - Rv0166 0.30 -1.1
195,560 + Rv0166 0.34 -0.9
195,561 - Rv0166 0.34 +0.3
195,641 + Rv0166 0.39 -0.8
195,642 - Rv0166 0.39 +0.6
195,758 + Rv0166 0.46 -0.6
195,859 + Rv0166 0.52 -0.5
195,860 - Rv0166 0.52 +0.5
195,895 - Rv0166 0.54 +0.4
196,294 + Rv0166 0.78 +0.2
196,295 - Rv0166 0.78 +0.6
196,316 + Rv0166 0.79 -0.9
196,316 + Rv0166 0.79 -0.1
196,317 - Rv0166 0.80 +0.1
196,458 + Rv0166 0.88 -0.6
196,458 + Rv0166 0.88 +1.4
196,490 + Rv0166 0.90 -0.4
196,656 - -0.0
196,684 - -0.2
196,700 + -1.6
196,701 - -1.6
196,757 - +0.1
197,091 + Rv0167 0.29 +1.4

Or see this region's nucleotide sequence