Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0002

Experiment: 7H9 with Moxifloxacin 0.121 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0001 and Rv0002 are separated by 527 nucleotidesRv0002 and Rv0003 are separated by 19 nucleotides Rv0001: Rv0001 - Chromosomal replication initiator protein DnaA, at 1 to 1,524 Rv0001 Rv0002: Rv0002 - DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase), at 2,052 to 3,260 Rv0002 Rv0003: Rv0003 - DNA replication and repair protein RecF (single-strand DNA binding protein), at 3,280 to 4,437 Rv0003 Position (kb) 2 3 4Strain fitness (log2 ratio) -3 -2 -1 0 1at 1.635 kb on + strandat 1.635 kb on + strandat 1.635 kb on + strandat 1.636 kb on - strandat 1.858 kb on + strandat 1.858 kb on + strandat 3.284 kb on - strandat 3.329 kb on + strandat 3.709 kb on - strand, within Rv0003at 3.782 kb on + strand, within Rv0003at 3.925 kb on + strand, within Rv0003

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Moxifloxacin 0.121 ug/mL
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1,635 + +0.5
1,635 + -3.2
1,635 + +1.5
1,636 - +0.5
1,858 + -1.1
1,858 + -1.1
3,284 - +0.7
3,329 + -2.0
3,709 - Rv0003 0.37 -2.0
3,782 + Rv0003 0.43 -1.4
3,925 + Rv0003 0.56 -2.6

Or see this region's nucleotide sequence