Experiment: Doxycycline hyclate 0.0001 mg/ml
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Pf6N2E2_2831 and Pf6N2E2_2832 are separated by 152 nucleotides Pf6N2E2_2832 and Pf6N2E2_2833 are separated by 329 nucleotides Pf6N2E2_2833 and Pf6N2E2_2834 are separated by 1 nucleotides
Pf6N2E2_2831 - 3-carboxy-cis,cis-muconate cycloisomerase (EC 5.5.1.2), at 3,319,781 to 3,321,145
_2831
Pf6N2E2_2832 - dicarboxylic acid transporter PcaT, at 3,321,298 to 3,322,596
_2832
Pf6N2E2_2833 - Protocatechuate 3,4-dioxygenase alpha chain (EC 1.13.11.3), at 3,322,926 to 3,323,492
_2833
Pf6N2E2_2834 - Protocatechuate 3,4-dioxygenase beta chain (EC 1.13.11.3), at 3,323,494 to 3,324,198
_2834
Position (kb)
3321
3322
3323 Strain fitness (log2 ratio)
-2
-1
0
1
2 at 3320.706 kb on + strand, within Pf6N2E2_2831 at 3320.706 kb on + strand, within Pf6N2E2_2831 at 3320.828 kb on + strand, within Pf6N2E2_2831 at 3320.828 kb on + strand, within Pf6N2E2_2831 at 3320.838 kb on + strand, within Pf6N2E2_2831 at 3320.839 kb on - strand, within Pf6N2E2_2831 at 3320.839 kb on - strand, within Pf6N2E2_2831 at 3320.839 kb on - strand, within Pf6N2E2_2831 at 3320.950 kb on - strand, within Pf6N2E2_2831 at 3321.108 kb on + strand at 3321.108 kb on + strand at 3321.109 kb on - strand at 3321.109 kb on - strand at 3321.109 kb on - strand at 3321.145 kb on + strand at 3321.145 kb on + strand at 3321.145 kb on + strand at 3321.165 kb on - strand at 3321.165 kb on - strand at 3321.165 kb on - strand at 3321.165 kb on - strand at 3321.165 kb on - strand at 3321.165 kb on - strand at 3321.165 kb on - strand at 3321.165 kb on - strand at 3321.317 kb on + strand at 3321.317 kb on + strand at 3321.380 kb on + strand at 3321.380 kb on + strand at 3321.380 kb on + strand at 3321.380 kb on + strand at 3321.381 kb on - strand at 3321.381 kb on - strand at 3321.381 kb on - strand at 3321.381 kb on - strand at 3321.431 kb on + strand, within Pf6N2E2_2832 at 3321.431 kb on + strand, within Pf6N2E2_2832 at 3321.431 kb on + strand, within Pf6N2E2_2832 at 3321.431 kb on + strand, within Pf6N2E2_2832 at 3321.432 kb on - strand, within Pf6N2E2_2832 at 3321.432 kb on - strand, within Pf6N2E2_2832 at 3321.432 kb on - strand, within Pf6N2E2_2832 at 3321.470 kb on + strand, within Pf6N2E2_2832 at 3321.471 kb on - strand, within Pf6N2E2_2832 at 3321.481 kb on + strand, within Pf6N2E2_2832 at 3321.481 kb on + strand, within Pf6N2E2_2832 at 3321.481 kb on + strand, within Pf6N2E2_2832 at 3321.482 kb on - strand, within Pf6N2E2_2832 at 3321.482 kb on - strand, within Pf6N2E2_2832 at 3321.482 kb on - strand, within Pf6N2E2_2832 at 3321.545 kb on + strand, within Pf6N2E2_2832 at 3321.545 kb on + strand, within Pf6N2E2_2832 at 3321.545 kb on + strand, within Pf6N2E2_2832 at 3321.546 kb on - strand, within Pf6N2E2_2832 at 3321.546 kb on - strand, within Pf6N2E2_2832 at 3321.546 kb on - strand, within Pf6N2E2_2832 at 3321.546 kb on - strand, within Pf6N2E2_2832 at 3321.546 kb on - strand, within Pf6N2E2_2832 at 3321.546 kb on - strand, within Pf6N2E2_2832 at 3321.676 kb on - strand, within Pf6N2E2_2832 at 3321.728 kb on + strand, within Pf6N2E2_2832 at 3321.728 kb on + strand, within Pf6N2E2_2832 at 3321.728 kb on + strand, within Pf6N2E2_2832 at 3321.728 kb on + strand, within Pf6N2E2_2832 at 3321.728 kb on + strand, within Pf6N2E2_2832 at 3321.728 kb on + strand, within Pf6N2E2_2832 at 3321.729 kb on - strand at 3321.729 kb on - strand, within Pf6N2E2_2832 at 3321.755 kb on + strand, within Pf6N2E2_2832 at 3321.755 kb on + strand, within Pf6N2E2_2832 at 3321.755 kb on + strand, within Pf6N2E2_2832 at 3321.756 kb on - strand, within Pf6N2E2_2832 at 3321.756 kb on - strand, within Pf6N2E2_2832 at 3321.756 kb on - strand, within Pf6N2E2_2832 at 3321.797 kb on + strand, within Pf6N2E2_2832 at 3321.797 kb on + strand, within Pf6N2E2_2832 at 3321.798 kb on - strand, within Pf6N2E2_2832 at 3321.798 kb on - strand, within Pf6N2E2_2832 at 3321.798 kb on - strand, within Pf6N2E2_2832 at 3321.809 kb on + strand, within Pf6N2E2_2832 at 3321.809 kb on + strand, within Pf6N2E2_2832 at 3321.809 kb on + strand, within Pf6N2E2_2832 at 3321.809 kb on + strand, within Pf6N2E2_2832 at 3321.809 kb on + strand, within Pf6N2E2_2832 at 3321.809 kb on + strand, within Pf6N2E2_2832 at 3321.809 kb on + strand, within Pf6N2E2_2832 at 3321.809 kb on + strand, within Pf6N2E2_2832 at 3321.809 kb on + strand, within Pf6N2E2_2832 at 3321.809 kb on + strand, within Pf6N2E2_2832 at 3321.809 kb on + strand, within Pf6N2E2_2832 at 3321.810 kb on - strand, within Pf6N2E2_2832 at 3321.810 kb on - strand, within Pf6N2E2_2832 at 3321.810 kb on - strand, within Pf6N2E2_2832 at 3321.810 kb on - strand, within Pf6N2E2_2832 at 3322.022 kb on + strand, within Pf6N2E2_2832 at 3322.023 kb on - strand, within Pf6N2E2_2832 at 3322.023 kb on - strand, within Pf6N2E2_2832 at 3322.109 kb on + strand, within Pf6N2E2_2832 at 3322.109 kb on + strand, within Pf6N2E2_2832 at 3322.163 kb on + strand, within Pf6N2E2_2832 at 3322.163 kb on + strand, within Pf6N2E2_2832 at 3322.163 kb on + strand, within Pf6N2E2_2832 at 3322.163 kb on + strand, within Pf6N2E2_2832 at 3322.163 kb on + strand, within Pf6N2E2_2832 at 3322.163 kb on + strand, within Pf6N2E2_2832 at 3322.163 kb on + strand, within Pf6N2E2_2832 at 3322.163 kb on + strand, within Pf6N2E2_2832 at 3322.164 kb on - strand, within Pf6N2E2_2832 at 3322.164 kb on - strand, within Pf6N2E2_2832 at 3322.164 kb on - strand, within Pf6N2E2_2832 at 3322.164 kb on - strand, within Pf6N2E2_2832 at 3322.164 kb on - strand, within Pf6N2E2_2832 at 3322.164 kb on - strand, within Pf6N2E2_2832 at 3322.164 kb on - strand, within Pf6N2E2_2832 at 3322.164 kb on - strand, within Pf6N2E2_2832 at 3322.164 kb on - strand, within Pf6N2E2_2832 at 3322.259 kb on + strand, within Pf6N2E2_2832 at 3322.259 kb on + strand, within Pf6N2E2_2832 at 3322.260 kb on - strand, within Pf6N2E2_2832 at 3322.260 kb on - strand, within Pf6N2E2_2832 at 3322.329 kb on + strand, within Pf6N2E2_2832 at 3322.330 kb on - strand, within Pf6N2E2_2832 at 3322.330 kb on - strand, within Pf6N2E2_2832 at 3322.484 kb on + strand at 3322.484 kb on + strand at 3322.485 kb on - strand at 3322.485 kb on - strand at 3322.485 kb on - strand at 3322.490 kb on + strand at 3322.490 kb on + strand at 3322.490 kb on + strand at 3322.490 kb on + strand at 3322.490 kb on + strand at 3322.490 kb on + strand at 3322.490 kb on + strand at 3322.490 kb on + strand at 3322.490 kb on + strand at 3322.490 kb on + strand at 3322.490 kb on + strand at 3322.490 kb on + strand at 3322.490 kb on + strand at 3322.490 kb on + strand at 3322.491 kb on - strand at 3322.491 kb on - strand at 3322.491 kb on - strand at 3322.491 kb on - strand at 3322.491 kb on - strand at 3322.491 kb on - strand at 3322.491 kb on - strand at 3322.491 kb on - strand at 3322.491 kb on - strand at 3322.491 kb on - strand at 3322.545 kb on + strand at 3322.545 kb on + strand at 3322.546 kb on - strand at 3322.546 kb on - strand at 3322.546 kb on - strand at 3322.572 kb on - strand at 3322.572 kb on - strand at 3322.572 kb on - strand at 3322.602 kb on + strand at 3322.640 kb on - strand at 3322.640 kb on - strand at 3322.640 kb on - strand at 3322.686 kb on + strand at 3322.730 kb on + strand at 3322.730 kb on + strand at 3322.730 kb on + strand at 3322.730 kb on + strand at 3322.731 kb on - strand at 3322.731 kb on - strand at 3322.731 kb on - strand at 3322.747 kb on - strand at 3322.747 kb on - strand at 3322.747 kb on - strand at 3322.747 kb on - strand at 3322.747 kb on - strand at 3322.754 kb on + strand at 3322.754 kb on + strand at 3322.754 kb on + strand at 3322.755 kb on - strand at 3322.853 kb on - strand at 3322.985 kb on - strand, within Pf6N2E2_2833 at 3323.086 kb on + strand, within Pf6N2E2_2833 at 3323.199 kb on - strand, within Pf6N2E2_2833 at 3323.199 kb on - strand, within Pf6N2E2_2833 at 3323.293 kb on + strand, within Pf6N2E2_2833 at 3323.293 kb on + strand, within Pf6N2E2_2833 at 3323.293 kb on + strand, within Pf6N2E2_2833 at 3323.294 kb on - strand, within Pf6N2E2_2833 at 3323.294 kb on - strand, within Pf6N2E2_2833 at 3323.294 kb on - strand, within Pf6N2E2_2833 at 3323.294 kb on - strand, within Pf6N2E2_2833 at 3323.449 kb on + strand at 3323.449 kb on + strand at 3323.450 kb on - strand at 3323.450 kb on - strand at 3323.453 kb on - strand at 3323.453 kb on - strand at 3323.495 kb on + strand at 3323.495 kb on + strand at 3323.495 kb on + strand at 3323.495 kb on + strand at 3323.495 kb on + strand at 3323.496 kb on - strand at 3323.496 kb on - strand at 3323.496 kb on - strand at 3323.496 kb on - strand at 3323.496 kb on - strand at 3323.496 kb on - strand at 3323.496 kb on - strand at 3323.558 kb on + strand
Per-strain Table
Position Strand Gene LocusTag Fraction Doxycycline hyclate 0.0001 mg/ml remove 3,320,706 + Pf6N2E2_2831 0.68 -0.4 3,320,706 + Pf6N2E2_2831 0.68 +0.9 3,320,828 + Pf6N2E2_2831 0.77 +1.2 3,320,828 + Pf6N2E2_2831 0.77 +0.4 3,320,838 + Pf6N2E2_2831 0.77 +1.0 3,320,839 - Pf6N2E2_2831 0.78 +1.6 3,320,839 - Pf6N2E2_2831 0.78 +0.2 3,320,839 - Pf6N2E2_2831 0.78 +0.0 3,320,950 - Pf6N2E2_2831 0.86 -1.1 3,321,108 + +1.4 3,321,108 + +1.0 3,321,109 - -1.1 3,321,109 - +0.2 3,321,109 - +0.4 3,321,145 + +0.9 3,321,145 + -0.9 3,321,145 + +1.2 3,321,165 - +0.2 3,321,165 - -2.4 3,321,165 - -0.2 3,321,165 - -0.8 3,321,165 - +0.2 3,321,165 - -1.1 3,321,165 - -0.2 3,321,165 - +1.1 3,321,317 + +0.5 3,321,317 + +0.9 3,321,380 + +0.3 3,321,380 + -0.4 3,321,380 + +0.6 3,321,380 + -0.0 3,321,381 - -0.5 3,321,381 - +0.0 3,321,381 - -0.2 3,321,381 - -0.4 3,321,431 + Pf6N2E2_2832 0.10 -1.1 3,321,431 + Pf6N2E2_2832 0.10 -1.0 3,321,431 + Pf6N2E2_2832 0.10 -0.4 3,321,431 + Pf6N2E2_2832 0.10 -0.5 3,321,432 - Pf6N2E2_2832 0.10 -1.2 3,321,432 - Pf6N2E2_2832 0.10 -0.3 3,321,432 - Pf6N2E2_2832 0.10 -1.2 3,321,470 + Pf6N2E2_2832 0.13 -2.7 3,321,471 - Pf6N2E2_2832 0.13 -0.8 3,321,481 + Pf6N2E2_2832 0.14 +0.6 3,321,481 + Pf6N2E2_2832 0.14 +1.4 3,321,481 + Pf6N2E2_2832 0.14 +0.6 3,321,482 - Pf6N2E2_2832 0.14 +0.9 3,321,482 - Pf6N2E2_2832 0.14 +0.5 3,321,482 - Pf6N2E2_2832 0.14 -1.5 3,321,545 + Pf6N2E2_2832 0.19 +0.3 3,321,545 + Pf6N2E2_2832 0.19 -0.4 3,321,545 + Pf6N2E2_2832 0.19 -0.5 3,321,546 - Pf6N2E2_2832 0.19 +0.1 3,321,546 - Pf6N2E2_2832 0.19 -1.7 3,321,546 - Pf6N2E2_2832 0.19 +0.5 3,321,546 - Pf6N2E2_2832 0.19 -0.1 3,321,546 - Pf6N2E2_2832 0.19 +0.2 3,321,546 - Pf6N2E2_2832 0.19 -0.3 3,321,676 - Pf6N2E2_2832 0.29 -1.5 3,321,728 + Pf6N2E2_2832 0.33 +0.2 3,321,728 + Pf6N2E2_2832 0.33 -0.0 3,321,728 + Pf6N2E2_2832 0.33 -0.4 3,321,728 + Pf6N2E2_2832 0.33 -0.1 3,321,728 + Pf6N2E2_2832 0.33 -1.0 3,321,728 + Pf6N2E2_2832 0.33 -1.5 3,321,729 - -0.5 3,321,729 - Pf6N2E2_2832 0.33 -0.5 3,321,755 + Pf6N2E2_2832 0.35 +0.6 3,321,755 + Pf6N2E2_2832 0.35 +0.4 3,321,755 + Pf6N2E2_2832 0.35 -1.7 3,321,756 - Pf6N2E2_2832 0.35 +0.2 3,321,756 - Pf6N2E2_2832 0.35 -0.4 3,321,756 - Pf6N2E2_2832 0.35 +0.0 3,321,797 + Pf6N2E2_2832 0.38 +0.3 3,321,797 + Pf6N2E2_2832 0.38 -1.4 3,321,798 - Pf6N2E2_2832 0.38 +1.2 3,321,798 - Pf6N2E2_2832 0.38 -2.0 3,321,798 - Pf6N2E2_2832 0.38 +0.5 3,321,809 + Pf6N2E2_2832 0.39 -0.5 3,321,809 + Pf6N2E2_2832 0.39 +1.2 3,321,809 + Pf6N2E2_2832 0.39 +1.2 3,321,809 + Pf6N2E2_2832 0.39 -0.5 3,321,809 + Pf6N2E2_2832 0.39 -0.1 3,321,809 + Pf6N2E2_2832 0.39 -0.0 3,321,809 + Pf6N2E2_2832 0.39 +1.8 3,321,809 + Pf6N2E2_2832 0.39 -1.1 3,321,809 + Pf6N2E2_2832 0.39 -1.3 3,321,809 + Pf6N2E2_2832 0.39 +0.2 3,321,809 + Pf6N2E2_2832 0.39 +0.2 3,321,810 - Pf6N2E2_2832 0.39 -1.1 3,321,810 - Pf6N2E2_2832 0.39 +1.1 3,321,810 - Pf6N2E2_2832 0.39 -1.7 3,321,810 - Pf6N2E2_2832 0.39 -0.5 3,322,022 + Pf6N2E2_2832 0.56 +0.9 3,322,023 - Pf6N2E2_2832 0.56 -0.3 3,322,023 - Pf6N2E2_2832 0.56 +0.3 3,322,109 + Pf6N2E2_2832 0.62 +0.6 3,322,109 + Pf6N2E2_2832 0.62 +0.6 3,322,163 + Pf6N2E2_2832 0.67 -0.5 3,322,163 + Pf6N2E2_2832 0.67 +0.5 3,322,163 + Pf6N2E2_2832 0.67 +0.3 3,322,163 + Pf6N2E2_2832 0.67 -2.0 3,322,163 + Pf6N2E2_2832 0.67 +0.0 3,322,163 + Pf6N2E2_2832 0.67 -0.8 3,322,163 + Pf6N2E2_2832 0.67 +0.9 3,322,163 + Pf6N2E2_2832 0.67 +1.1 3,322,164 - Pf6N2E2_2832 0.67 +0.5 3,322,164 - Pf6N2E2_2832 0.67 -0.7 3,322,164 - Pf6N2E2_2832 0.67 +0.5 3,322,164 - Pf6N2E2_2832 0.67 +0.0 3,322,164 - Pf6N2E2_2832 0.67 -0.4 3,322,164 - Pf6N2E2_2832 0.67 -0.7 3,322,164 - Pf6N2E2_2832 0.67 +0.9 3,322,164 - Pf6N2E2_2832 0.67 +0.0 3,322,164 - Pf6N2E2_2832 0.67 -0.4 3,322,259 + Pf6N2E2_2832 0.74 -1.2 3,322,259 + Pf6N2E2_2832 0.74 -0.4 3,322,260 - Pf6N2E2_2832 0.74 +0.5 3,322,260 - Pf6N2E2_2832 0.74 +0.0 3,322,329 + Pf6N2E2_2832 0.79 +0.5 3,322,330 - Pf6N2E2_2832 0.79 +0.8 3,322,330 - Pf6N2E2_2832 0.79 -0.9 3,322,484 + +0.0 3,322,484 + +0.6 3,322,485 - -0.8 3,322,485 - +1.0 3,322,485 - +0.5 3,322,490 + +0.3 3,322,490 + +0.3 3,322,490 + -1.2 3,322,490 + +0.8 3,322,490 + -0.9 3,322,490 + -0.1 3,322,490 + -0.1 3,322,490 + -1.0 3,322,490 + +0.5 3,322,490 + +1.8 3,322,490 + +1.0 3,322,490 + -0.6 3,322,490 + +1.1 3,322,490 + +0.7 3,322,491 - -0.2 3,322,491 - -2.2 3,322,491 - +1.0 3,322,491 - +1.1 3,322,491 - -1.5 3,322,491 - +1.4 3,322,491 - -0.7 3,322,491 - +0.1 3,322,491 - +0.6 3,322,491 - -0.3 3,322,545 + +1.6 3,322,545 + -0.3 3,322,546 - -0.3 3,322,546 - -0.2 3,322,546 - +1.0 3,322,572 - -0.3 3,322,572 - -0.7 3,322,572 - +0.7 3,322,602 + -0.6 3,322,640 - -0.9 3,322,640 - -0.9 3,322,640 - +0.1 3,322,686 + -0.2 3,322,730 + +1.8 3,322,730 + +0.1 3,322,730 + +1.7 3,322,730 + -0.5 3,322,731 - +0.0 3,322,731 - +0.5 3,322,731 - +1.0 3,322,747 - +1.7 3,322,747 - +1.7 3,322,747 - -0.3 3,322,747 - -0.0 3,322,747 - +2.0 3,322,754 + +0.1 3,322,754 + -0.5 3,322,754 + -0.5 3,322,755 - -0.3 3,322,853 - +0.6 3,322,985 - Pf6N2E2_2833 0.10 -0.1 3,323,086 + Pf6N2E2_2833 0.28 -1.3 3,323,199 - Pf6N2E2_2833 0.48 +0.4 3,323,199 - Pf6N2E2_2833 0.48 -0.6 3,323,293 + Pf6N2E2_2833 0.65 -0.8 3,323,293 + Pf6N2E2_2833 0.65 -0.3 3,323,293 + Pf6N2E2_2833 0.65 +0.6 3,323,294 - Pf6N2E2_2833 0.65 -0.2 3,323,294 - Pf6N2E2_2833 0.65 -2.0 3,323,294 - Pf6N2E2_2833 0.65 +0.7 3,323,294 - Pf6N2E2_2833 0.65 -0.5 3,323,449 + +1.7 3,323,449 + +0.9 3,323,450 - +0.1 3,323,450 - +0.8 3,323,453 - -0.5 3,323,453 - -0.5 3,323,495 + +0.1 3,323,495 + +1.0 3,323,495 + +0.5 3,323,495 + +0.3 3,323,495 + +0.8 3,323,496 - -0.5 3,323,496 - +1.1 3,323,496 - -0.4 3,323,496 - +0.0 3,323,496 - -1.0 3,323,496 - -0.8 3,323,496 - +0.8 3,323,558 + +0.8
Or see this region's nucleotide sequence