Experiment: PYE with Cisplatin 0.005 mg/ml
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt CCNA_01503 and CCNA_01502 overlap by 2 nucleotides CCNA_01502 and CCNA_01504 are separated by 8 nucleotides CCNA_01504 and CCNA_01505 are separated by 42 nucleotides CCNA_01505 and CCNA_01506 are separated by 65 nucleotides
CCNA_01503: CCNA_01503 - phosphotransferase family protein, at 1,612,264 to 1,613,346
_01503
CCNA_01502: CCNA_01502 - conserved membrane spanning protein, at 1,613,345 to 1,614,289
_01502
CCNA_01504: CCNA_01504 - ATP-dependent DNA helicase recG, at 1,614,298 to 1,616,394
_01504
CCNA_01505: CCNA_01505 - hypothetical protein, at 1,616,437 to 1,616,739
_01505
CCNA_01506: CCNA_01506 - cystine transport ATP-binding protein, at 1,616,805 to 1,617,545
_01506
Position (kb)
1614
1615
1616
1617 Strain fitness (log2 ratio)
-3
-2
-1
0
1
2 at 1613.307 kb on + strand at 1613.310 kb on - strand at 1613.326 kb on + strand at 1613.326 kb on + strand at 1613.326 kb on + strand at 1613.334 kb on - strand at 1613.357 kb on - strand at 1613.408 kb on + strand at 1613.408 kb on + strand at 1613.448 kb on - strand, within CCNA_01502 at 1613.543 kb on + strand, within CCNA_01502 at 1613.592 kb on + strand, within CCNA_01502 at 1613.669 kb on - strand, within CCNA_01502 at 1613.689 kb on - strand, within CCNA_01502 at 1613.691 kb on + strand, within CCNA_01502 at 1613.781 kb on + strand, within CCNA_01502 at 1613.781 kb on + strand, within CCNA_01502 at 1613.786 kb on + strand, within CCNA_01502 at 1613.787 kb on + strand, within CCNA_01502 at 1613.792 kb on + strand, within CCNA_01502 at 1613.799 kb on - strand, within CCNA_01502 at 1613.801 kb on + strand, within CCNA_01502 at 1613.801 kb on + strand, within CCNA_01502 at 1613.837 kb on + strand, within CCNA_01502 at 1613.837 kb on + strand, within CCNA_01502 at 1613.845 kb on - strand, within CCNA_01502 at 1613.845 kb on - strand, within CCNA_01502 at 1613.845 kb on - strand, within CCNA_01502 at 1613.857 kb on + strand, within CCNA_01502 at 1613.864 kb on + strand, within CCNA_01502 at 1613.865 kb on + strand, within CCNA_01502 at 1613.870 kb on + strand, within CCNA_01502 at 1613.870 kb on + strand, within CCNA_01502 at 1613.873 kb on - strand, within CCNA_01502 at 1613.875 kb on + strand, within CCNA_01502 at 1613.888 kb on - strand, within CCNA_01502 at 1613.948 kb on + strand, within CCNA_01502 at 1613.951 kb on - strand, within CCNA_01502 at 1613.953 kb on + strand, within CCNA_01502 at 1613.988 kb on + strand, within CCNA_01502 at 1613.998 kb on + strand, within CCNA_01502 at 1613.998 kb on + strand, within CCNA_01502 at 1613.998 kb on + strand, within CCNA_01502 at 1613.998 kb on + strand, within CCNA_01502 at 1613.998 kb on + strand, within CCNA_01502 at 1614.006 kb on - strand, within CCNA_01502 at 1614.006 kb on - strand, within CCNA_01502 at 1614.006 kb on - strand, within CCNA_01502 at 1614.018 kb on + strand, within CCNA_01502 at 1614.055 kb on + strand, within CCNA_01502 at 1614.055 kb on + strand, within CCNA_01502 at 1614.063 kb on - strand, within CCNA_01502 at 1614.095 kb on - strand, within CCNA_01502 at 1614.095 kb on - strand, within CCNA_01502 at 1614.105 kb on - strand, within CCNA_01502 at 1614.118 kb on + strand, within CCNA_01502 at 1614.168 kb on - strand, within CCNA_01502 at 1614.172 kb on + strand, within CCNA_01502 at 1614.241 kb on - strand at 1614.242 kb on + strand at 1614.261 kb on - strand at 1614.288 kb on + strand at 1614.291 kb on - strand at 1614.296 kb on - strand at 1614.296 kb on - strand at 1614.305 kb on + strand at 1614.310 kb on + strand at 1614.351 kb on - strand at 1614.355 kb on + strand at 1614.379 kb on + strand at 1614.379 kb on + strand at 1614.403 kb on + strand at 1614.489 kb on + strand at 1614.530 kb on - strand, within CCNA_01504 at 1614.552 kb on - strand, within CCNA_01504 at 1614.583 kb on + strand, within CCNA_01504 at 1614.606 kb on - strand, within CCNA_01504 at 1614.651 kb on + strand, within CCNA_01504 at 1614.732 kb on + strand, within CCNA_01504 at 1614.732 kb on + strand, within CCNA_01504 at 1614.732 kb on + strand, within CCNA_01504 at 1614.733 kb on + strand, within CCNA_01504 at 1614.743 kb on + strand, within CCNA_01504 at 1614.765 kb on + strand, within CCNA_01504 at 1614.804 kb on - strand, within CCNA_01504 at 1614.819 kb on - strand, within CCNA_01504 at 1614.885 kb on + strand, within CCNA_01504 at 1614.893 kb on - strand, within CCNA_01504 at 1614.893 kb on - strand, within CCNA_01504 at 1614.906 kb on - strand, within CCNA_01504 at 1615.029 kb on - strand, within CCNA_01504 at 1615.083 kb on - strand, within CCNA_01504 at 1615.124 kb on + strand, within CCNA_01504 at 1615.137 kb on - strand, within CCNA_01504 at 1615.154 kb on + strand, within CCNA_01504 at 1615.173 kb on - strand, within CCNA_01504 at 1615.191 kb on + strand, within CCNA_01504 at 1615.219 kb on + strand, within CCNA_01504 at 1615.224 kb on + strand, within CCNA_01504 at 1615.224 kb on + strand, within CCNA_01504 at 1615.227 kb on - strand, within CCNA_01504 at 1615.227 kb on - strand, within CCNA_01504 at 1615.232 kb on - strand, within CCNA_01504 at 1615.232 kb on - strand, within CCNA_01504 at 1615.268 kb on - strand, within CCNA_01504 at 1615.292 kb on + strand, within CCNA_01504 at 1615.374 kb on - strand, within CCNA_01504 at 1615.374 kb on - strand, within CCNA_01504 at 1615.449 kb on + strand, within CCNA_01504 at 1615.508 kb on + strand, within CCNA_01504 at 1615.518 kb on + strand, within CCNA_01504 at 1615.574 kb on + strand, within CCNA_01504 at 1615.582 kb on - strand, within CCNA_01504 at 1615.630 kb on - strand, within CCNA_01504 at 1615.676 kb on + strand, within CCNA_01504 at 1615.684 kb on - strand, within CCNA_01504 at 1615.684 kb on - strand, within CCNA_01504 at 1615.684 kb on - strand, within CCNA_01504 at 1615.684 kb on - strand, within CCNA_01504 at 1615.684 kb on - strand, within CCNA_01504 at 1615.684 kb on - strand, within CCNA_01504 at 1615.684 kb on - strand, within CCNA_01504 at 1615.857 kb on + strand, within CCNA_01504 at 1615.857 kb on + strand, within CCNA_01504 at 1615.857 kb on + strand, within CCNA_01504 at 1615.865 kb on - strand, within CCNA_01504 at 1615.865 kb on - strand, within CCNA_01504 at 1615.865 kb on - strand, within CCNA_01504 at 1615.865 kb on - strand, within CCNA_01504 at 1615.865 kb on - strand, within CCNA_01504 at 1615.878 kb on - strand, within CCNA_01504 at 1615.914 kb on + strand, within CCNA_01504 at 1615.936 kb on - strand, within CCNA_01504 at 1615.945 kb on - strand, within CCNA_01504 at 1615.945 kb on - strand, within CCNA_01504 at 1615.961 kb on + strand, within CCNA_01504 at 1615.961 kb on + strand, within CCNA_01504 at 1615.961 kb on + strand, within CCNA_01504 at 1615.969 kb on - strand, within CCNA_01504 at 1615.969 kb on - strand, within CCNA_01504 at 1615.969 kb on - strand, within CCNA_01504 at 1616.046 kb on - strand, within CCNA_01504 at 1616.060 kb on + strand, within CCNA_01504 at 1616.060 kb on + strand, within CCNA_01504 at 1616.068 kb on - strand, within CCNA_01504 at 1616.068 kb on - strand, within CCNA_01504 at 1616.068 kb on - strand, within CCNA_01504 at 1616.068 kb on - strand, within CCNA_01504 at 1616.068 kb on - strand, within CCNA_01504 at 1616.068 kb on - strand, within CCNA_01504 at 1616.070 kb on - strand, within CCNA_01504 at 1616.097 kb on + strand, within CCNA_01504 at 1616.105 kb on - strand, within CCNA_01504 at 1616.105 kb on - strand, within CCNA_01504 at 1616.110 kb on - strand, within CCNA_01504 at 1616.130 kb on + strand, within CCNA_01504 at 1616.157 kb on + strand, within CCNA_01504 at 1616.165 kb on - strand, within CCNA_01504 at 1616.165 kb on - strand, within CCNA_01504 at 1616.211 kb on - strand at 1616.212 kb on - strand at 1616.237 kb on - strand at 1616.254 kb on + strand at 1616.262 kb on - strand at 1616.262 kb on - strand at 1616.267 kb on - strand at 1616.300 kb on - strand at 1616.300 kb on - strand at 1616.317 kb on - strand at 1616.343 kb on - strand at 1616.368 kb on - strand at 1616.444 kb on + strand at 1616.483 kb on + strand, within CCNA_01505 at 1616.493 kb on - strand, within CCNA_01505 at 1616.559 kb on + strand, within CCNA_01505 at 1616.581 kb on - strand, within CCNA_01505 at 1616.596 kb on + strand, within CCNA_01505 at 1616.604 kb on - strand, within CCNA_01505 at 1616.673 kb on - strand, within CCNA_01505 at 1616.682 kb on - strand, within CCNA_01505 at 1616.741 kb on - strand at 1616.741 kb on - strand at 1616.741 kb on - strand at 1616.751 kb on - strand at 1616.780 kb on - strand at 1616.788 kb on - strand at 1616.827 kb on - strand at 1616.852 kb on - strand at 1616.869 kb on - strand at 1616.892 kb on + strand, within CCNA_01506 at 1616.894 kb on - strand, within CCNA_01506 at 1616.900 kb on - strand, within CCNA_01506 at 1616.965 kb on - strand, within CCNA_01506 at 1617.022 kb on - strand, within CCNA_01506 at 1617.022 kb on - strand, within CCNA_01506 at 1617.029 kb on + strand, within CCNA_01506 at 1617.037 kb on - strand, within CCNA_01506 at 1617.054 kb on - strand, within CCNA_01506 at 1617.092 kb on - strand, within CCNA_01506 at 1617.119 kb on - strand, within CCNA_01506 at 1617.139 kb on + strand, within CCNA_01506 at 1617.147 kb on + strand, within CCNA_01506 at 1617.153 kb on - strand, within CCNA_01506 at 1617.183 kb on + strand, within CCNA_01506 at 1617.191 kb on - strand, within CCNA_01506 at 1617.252 kb on + strand, within CCNA_01506 at 1617.252 kb on + strand, within CCNA_01506 at 1617.252 kb on + strand, within CCNA_01506 at 1617.252 kb on + strand, within CCNA_01506 at 1617.257 kb on + strand, within CCNA_01506 at 1617.259 kb on + strand, within CCNA_01506 at 1617.260 kb on - strand, within CCNA_01506 at 1617.260 kb on - strand, within CCNA_01506 at 1617.285 kb on + strand, within CCNA_01506 at 1617.286 kb on - strand, within CCNA_01506 at 1617.286 kb on - strand, within CCNA_01506 at 1617.298 kb on + strand at 1617.312 kb on + strand, within CCNA_01506 at 1617.319 kb on + strand, within CCNA_01506 at 1617.321 kb on - strand, within CCNA_01506 at 1617.327 kb on - strand, within CCNA_01506 at 1617.327 kb on - strand, within CCNA_01506 at 1617.327 kb on - strand, within CCNA_01506 at 1617.332 kb on - strand, within CCNA_01506 at 1617.332 kb on - strand, within CCNA_01506 at 1617.332 kb on - strand, within CCNA_01506
Per-strain Table
Position Strand Gene LocusTag Fraction PYE with Cisplatin 0.005 mg/ml remove 1,613,307 + +0.1 1,613,310 - -0.4 1,613,326 + +0.0 1,613,326 + +0.4 1,613,326 + +1.4 1,613,334 - -1.2 1,613,357 - +1.2 1,613,408 + -1.2 1,613,408 + -0.1 1,613,448 - CCNA_01502 0.11 -0.7 1,613,543 + CCNA_01502 0.21 -1.1 1,613,592 + CCNA_01502 0.26 -1.6 1,613,669 - CCNA_01502 0.34 +0.9 1,613,689 - CCNA_01502 0.36 -1.0 1,613,691 + CCNA_01502 0.37 +1.6 1,613,781 + CCNA_01502 0.46 +0.1 1,613,781 + CCNA_01502 0.46 +2.0 1,613,786 + CCNA_01502 0.47 +0.2 1,613,787 + CCNA_01502 0.47 -0.6 1,613,792 + CCNA_01502 0.47 -0.1 1,613,799 - CCNA_01502 0.48 -0.7 1,613,801 + CCNA_01502 0.48 -0.0 1,613,801 + CCNA_01502 0.48 +0.8 1,613,837 + CCNA_01502 0.52 +0.6 1,613,837 + CCNA_01502 0.52 -1.3 1,613,845 - CCNA_01502 0.53 -1.6 1,613,845 - CCNA_01502 0.53 +0.9 1,613,845 - CCNA_01502 0.53 +0.7 1,613,857 + CCNA_01502 0.54 +0.6 1,613,864 + CCNA_01502 0.55 +0.9 1,613,865 + CCNA_01502 0.55 +0.9 1,613,870 + CCNA_01502 0.56 +0.6 1,613,870 + CCNA_01502 0.56 +0.2 1,613,873 - CCNA_01502 0.56 +0.6 1,613,875 + CCNA_01502 0.56 +0.9 1,613,888 - CCNA_01502 0.57 +0.3 1,613,948 + CCNA_01502 0.64 +0.9 1,613,951 - CCNA_01502 0.64 -0.1 1,613,953 + CCNA_01502 0.64 -0.2 1,613,988 + CCNA_01502 0.68 -0.2 1,613,998 + CCNA_01502 0.69 +1.3 1,613,998 + CCNA_01502 0.69 -0.3 1,613,998 + CCNA_01502 0.69 +0.4 1,613,998 + CCNA_01502 0.69 +0.2 1,613,998 + CCNA_01502 0.69 +0.8 1,614,006 - CCNA_01502 0.70 -0.3 1,614,006 - CCNA_01502 0.70 -1.6 1,614,006 - CCNA_01502 0.70 -2.4 1,614,018 + CCNA_01502 0.71 +1.6 1,614,055 + CCNA_01502 0.75 +1.4 1,614,055 + CCNA_01502 0.75 +1.5 1,614,063 - CCNA_01502 0.76 +1.5 1,614,095 - CCNA_01502 0.79 -0.5 1,614,095 - CCNA_01502 0.79 +0.0 1,614,105 - CCNA_01502 0.80 -1.9 1,614,118 + CCNA_01502 0.82 +1.5 1,614,168 - CCNA_01502 0.87 +0.0 1,614,172 + CCNA_01502 0.88 +0.3 1,614,241 - -1.7 1,614,242 + +0.2 1,614,261 - +0.8 1,614,288 + +0.1 1,614,291 - -0.3 1,614,296 - -0.0 1,614,296 - +1.6 1,614,305 + -1.3 1,614,310 + -0.7 1,614,351 - -2.7 1,614,355 + -1.8 1,614,379 + -0.4 1,614,379 + -1.8 1,614,403 + -1.0 1,614,489 + -0.8 1,614,530 - CCNA_01504 0.11 -3.1 1,614,552 - CCNA_01504 0.12 -1.6 1,614,583 + CCNA_01504 0.14 +0.6 1,614,606 - CCNA_01504 0.15 -2.0 1,614,651 + CCNA_01504 0.17 +0.1 1,614,732 + CCNA_01504 0.21 -0.7 1,614,732 + CCNA_01504 0.21 -1.7 1,614,732 + CCNA_01504 0.21 -2.5 1,614,733 + CCNA_01504 0.21 +0.1 1,614,743 + CCNA_01504 0.21 -0.7 1,614,765 + CCNA_01504 0.22 -3.7 1,614,804 - CCNA_01504 0.24 -2.3 1,614,819 - CCNA_01504 0.25 -1.5 1,614,885 + CCNA_01504 0.28 -2.0 1,614,893 - CCNA_01504 0.28 -1.8 1,614,893 - CCNA_01504 0.28 -2.2 1,614,906 - CCNA_01504 0.29 +0.3 1,615,029 - CCNA_01504 0.35 -1.6 1,615,083 - CCNA_01504 0.37 -3.3 1,615,124 + CCNA_01504 0.39 -0.7 1,615,137 - CCNA_01504 0.40 -1.4 1,615,154 + CCNA_01504 0.41 -0.6 1,615,173 - CCNA_01504 0.42 -1.3 1,615,191 + CCNA_01504 0.43 -2.6 1,615,219 + CCNA_01504 0.44 -1.1 1,615,224 + CCNA_01504 0.44 -1.2 1,615,224 + CCNA_01504 0.44 -1.5 1,615,227 - CCNA_01504 0.44 -0.7 1,615,227 - CCNA_01504 0.44 -2.7 1,615,232 - CCNA_01504 0.45 -2.9 1,615,232 - CCNA_01504 0.45 -2.0 1,615,268 - CCNA_01504 0.46 -1.2 1,615,292 + CCNA_01504 0.47 +1.3 1,615,374 - CCNA_01504 0.51 -2.4 1,615,374 - CCNA_01504 0.51 -2.0 1,615,449 + CCNA_01504 0.55 -2.0 1,615,508 + CCNA_01504 0.58 -1.7 1,615,518 + CCNA_01504 0.58 +0.1 1,615,574 + CCNA_01504 0.61 -1.8 1,615,582 - CCNA_01504 0.61 -1.5 1,615,630 - CCNA_01504 0.64 -1.7 1,615,676 + CCNA_01504 0.66 -0.5 1,615,684 - CCNA_01504 0.66 -2.0 1,615,684 - CCNA_01504 0.66 -1.6 1,615,684 - CCNA_01504 0.66 -1.6 1,615,684 - CCNA_01504 0.66 -1.7 1,615,684 - CCNA_01504 0.66 -1.8 1,615,684 - CCNA_01504 0.66 -2.1 1,615,684 - CCNA_01504 0.66 -3.1 1,615,857 + CCNA_01504 0.74 -1.3 1,615,857 + CCNA_01504 0.74 +0.6 1,615,857 + CCNA_01504 0.74 -2.5 1,615,865 - CCNA_01504 0.75 -1.5 1,615,865 - CCNA_01504 0.75 -1.6 1,615,865 - CCNA_01504 0.75 -2.0 1,615,865 - CCNA_01504 0.75 -1.7 1,615,865 - CCNA_01504 0.75 +0.9 1,615,878 - CCNA_01504 0.75 -2.5 1,615,914 + CCNA_01504 0.77 -0.7 1,615,936 - CCNA_01504 0.78 -1.2 1,615,945 - CCNA_01504 0.79 -2.4 1,615,945 - CCNA_01504 0.79 -2.2 1,615,961 + CCNA_01504 0.79 -0.3 1,615,961 + CCNA_01504 0.79 +0.1 1,615,961 + CCNA_01504 0.79 -1.6 1,615,969 - CCNA_01504 0.80 -1.2 1,615,969 - CCNA_01504 0.80 -1.5 1,615,969 - CCNA_01504 0.80 -1.6 1,616,046 - CCNA_01504 0.83 -2.2 1,616,060 + CCNA_01504 0.84 -1.6 1,616,060 + CCNA_01504 0.84 -2.9 1,616,068 - CCNA_01504 0.84 -1.1 1,616,068 - CCNA_01504 0.84 -2.6 1,616,068 - CCNA_01504 0.84 +0.1 1,616,068 - CCNA_01504 0.84 -3.0 1,616,068 - CCNA_01504 0.84 -2.4 1,616,068 - CCNA_01504 0.84 -2.7 1,616,070 - CCNA_01504 0.85 -3.0 1,616,097 + CCNA_01504 0.86 -1.5 1,616,105 - CCNA_01504 0.86 +0.6 1,616,105 - CCNA_01504 0.86 +0.9 1,616,110 - CCNA_01504 0.86 -2.1 1,616,130 + CCNA_01504 0.87 -2.5 1,616,157 + CCNA_01504 0.89 -0.5 1,616,165 - CCNA_01504 0.89 -3.1 1,616,165 - CCNA_01504 0.89 -0.5 1,616,211 - -3.3 1,616,212 - -1.9 1,616,237 - -1.5 1,616,254 + -0.2 1,616,262 - -0.8 1,616,262 - -2.3 1,616,267 - -2.2 1,616,300 - -1.8 1,616,300 - -0.9 1,616,317 - -1.6 1,616,343 - -1.8 1,616,368 - +0.3 1,616,444 + +0.2 1,616,483 + CCNA_01505 0.15 -2.3 1,616,493 - CCNA_01505 0.18 +1.3 1,616,559 + CCNA_01505 0.40 +0.9 1,616,581 - CCNA_01505 0.48 +1.3 1,616,596 + CCNA_01505 0.52 -2.8 1,616,604 - CCNA_01505 0.55 +1.1 1,616,673 - CCNA_01505 0.78 +1.8 1,616,682 - CCNA_01505 0.81 +0.6 1,616,741 - +1.0 1,616,741 - +0.9 1,616,741 - +2.0 1,616,751 - +1.5 1,616,780 - +0.5 1,616,788 - +0.9 1,616,827 - +1.0 1,616,852 - +1.1 1,616,869 - +1.2 1,616,892 + CCNA_01506 0.12 +1.9 1,616,894 - CCNA_01506 0.12 +0.9 1,616,900 - CCNA_01506 0.13 -1.5 1,616,965 - CCNA_01506 0.22 -0.7 1,617,022 - CCNA_01506 0.29 +1.1 1,617,022 - CCNA_01506 0.29 +1.6 1,617,029 + CCNA_01506 0.30 -1.4 1,617,037 - CCNA_01506 0.31 +0.6 1,617,054 - CCNA_01506 0.34 -0.3 1,617,092 - CCNA_01506 0.39 -0.4 1,617,119 - CCNA_01506 0.42 +0.1 1,617,139 + CCNA_01506 0.45 -0.5 1,617,147 + CCNA_01506 0.46 -0.0 1,617,153 - CCNA_01506 0.47 -0.2 1,617,183 + CCNA_01506 0.51 -1.0 1,617,191 - CCNA_01506 0.52 +0.9 1,617,252 + CCNA_01506 0.60 +0.6 1,617,252 + CCNA_01506 0.60 -2.2 1,617,252 + CCNA_01506 0.60 -1.4 1,617,252 + CCNA_01506 0.60 -0.1 1,617,257 + CCNA_01506 0.61 -1.9 1,617,259 + CCNA_01506 0.61 +1.1 1,617,260 - CCNA_01506 0.61 -0.1 1,617,260 - CCNA_01506 0.61 +0.2 1,617,285 + CCNA_01506 0.65 -1.6 1,617,286 - CCNA_01506 0.65 -2.4 1,617,286 - CCNA_01506 0.65 -0.5 1,617,298 + +1.3 1,617,312 + CCNA_01506 0.68 +0.6 1,617,319 + CCNA_01506 0.69 -2.4 1,617,321 - CCNA_01506 0.70 +0.4 1,617,327 - CCNA_01506 0.70 -1.0 1,617,327 - CCNA_01506 0.70 +1.2 1,617,327 - CCNA_01506 0.70 +0.2 1,617,332 - CCNA_01506 0.71 +0.7 1,617,332 - CCNA_01506 0.71 -0.8 1,617,332 - CCNA_01506 0.71 -1.3
Or see this region's nucleotide sequence