Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1420

Experiment: Glycine 10 mM (N)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1418 and Rv1419 are separated by 179 nucleotidesRv1419 and Rv1420 are separated by 63 nucleotidesRv1420 and Rv1421 overlap by 4 nucleotidesRv1421 and Rv1422 overlap by 4 nucleotides Rv1418: Rv1418 - Probable lipoprotein LprH, at 1,592,639 to 1,593,325 Rv1418 Rv1419: Rv1419 - Unknown protein, at 1,593,505 to 1,593,978 Rv1419 Rv1420: Rv1420 - Probable excinuclease ABC (subunit C-nuclease) UvrC, at 1,594,042 to 1,595,982 Rv1420 Rv1421: Rv1421 - Conserved protein, at 1,595,979 to 1,596,884 Rv1421 Rv1422: Rv1422 - Conserved hypothetical protein, at 1,596,881 to 1,597,909 Rv1422 Position (kb) 1594 1595 1596Strain fitness (log2 ratio) -2 -1 0 1 2at 1593.171 kb on + strand, within Rv1418at 1593.171 kb on + strand, within Rv1418at 1593.172 kb on - strand, within Rv1418at 1593.515 kb on + strandat 1593.515 kb on + strandat 1593.516 kb on - strandat 1594.031 kb on - strandat 1594.035 kb on + strandat 1594.036 kb on - strandat 1594.036 kb on - strandat 1594.036 kb on - strandat 1594.039 kb on + strandat 1594.039 kb on + strandat 1594.039 kb on + strandat 1594.135 kb on + strandat 1594.178 kb on - strandat 1594.288 kb on + strand, within Rv1420at 1594.349 kb on - strand, within Rv1420at 1594.349 kb on - strand, within Rv1420at 1594.591 kb on - strand, within Rv1420at 1595.759 kb on - strand, within Rv1420at 1596.105 kb on + strand, within Rv1421at 1596.400 kb on + strand, within Rv1421at 1596.710 kb on - strand, within Rv1421at 1596.753 kb on - strand, within Rv1421at 1596.783 kb on - strand, within Rv1421at 1596.960 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction Glycine 10 mM (N)
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1,593,171 + Rv1418 0.77 -0.4
1,593,171 + Rv1418 0.77 -0.3
1,593,172 - Rv1418 0.78 +0.1
1,593,515 + +0.3
1,593,515 + +0.3
1,593,516 - +0.6
1,594,031 - -0.7
1,594,035 + -0.9
1,594,036 - -1.9
1,594,036 - -0.5
1,594,036 - +0.6
1,594,039 + +0.7
1,594,039 + -0.6
1,594,039 + +0.0
1,594,135 + -0.6
1,594,178 - -1.1
1,594,288 + Rv1420 0.13 -0.2
1,594,349 - Rv1420 0.16 +1.8
1,594,349 - Rv1420 0.16 -2.1
1,594,591 - Rv1420 0.28 -1.7
1,595,759 - Rv1420 0.88 -1.0
1,596,105 + Rv1421 0.14 -0.8
1,596,400 + Rv1421 0.46 -2.0
1,596,710 - Rv1421 0.81 -1.8
1,596,753 - Rv1421 0.85 -1.5
1,596,783 - Rv1421 0.89 -1.7
1,596,960 - +1.6

Or see this region's nucleotide sequence