Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0376c

Experiment: Glycine 10 mM (N)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0374c and Rv0375c are separated by 14 nucleotidesRv0375c and Rv0376c are separated by 75 nucleotidesRv0376c and Rv0377 are separated by 48 nucleotides Rv0374c: Rv0374c - Probable carbon monoxyde dehydrogenase (small chain), at 451,800 to 452,279 Rv0374c Rv0375c: Rv0375c - Probable carbon monoxyde dehydrogenase (medium chain), at 452,294 to 453,154 Rv0375c Rv0376c: Rv0376c - Conserved hypothetical protein, at 453,230 to 454,372 Rv0376c Rv0377: Rv0377 - Probable transcriptional regulatory protein (probably LysR-family), at 454,421 to 455,386 Rv0377 Position (kb) 453 454 455Strain fitness (log2 ratio) -2 -1 0 1at 452.386 kb on - strand, within Rv0375cat 452.386 kb on - strand, within Rv0375cat 453.007 kb on - strand, within Rv0375cat 453.189 kb on - strandat 453.189 kb on - strandat 453.242 kb on + strandat 453.243 kb on - strandat 453.243 kb on - strandat 453.243 kb on - strandat 453.243 kb on - strandat 453.243 kb on - strandat 453.246 kb on + strandat 453.505 kb on - strand, within Rv0376cat 454.137 kb on - strand, within Rv0376cat 454.218 kb on + strand, within Rv0376cat 454.218 kb on + strand, within Rv0376cat 454.219 kb on - strand, within Rv0376cat 454.221 kb on - strand, within Rv0376cat 454.259 kb on + strandat 454.260 kb on - strandat 454.278 kb on - strandat 454.278 kb on - strandat 454.564 kb on + strand, within Rv0377at 454.900 kb on - strand, within Rv0377at 455.025 kb on + strand, within Rv0377at 455.026 kb on - strand, within Rv0377at 455.308 kb on + strandat 455.308 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction Glycine 10 mM (N)
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452,386 - Rv0375c 0.11 +0.1
452,386 - Rv0375c 0.11 +0.5
453,007 - Rv0375c 0.83 -2.3
453,189 - +1.1
453,189 - -0.8
453,242 + -0.9
453,243 - -0.0
453,243 - -1.0
453,243 - +0.0
453,243 - -0.1
453,243 - -0.2
453,246 + -0.6
453,505 - Rv0376c 0.24 +0.3
454,137 - Rv0376c 0.79 -1.4
454,218 + Rv0376c 0.86 -1.8
454,218 + Rv0376c 0.86 -0.1
454,219 - Rv0376c 0.87 -1.0
454,221 - Rv0376c 0.87 -0.5
454,259 + +0.4
454,260 - -0.4
454,278 - +0.8
454,278 - +0.2
454,564 + Rv0377 0.15 -0.3
454,900 - Rv0377 0.50 -0.1
455,025 + Rv0377 0.63 +0.3
455,026 - Rv0377 0.63 -0.2
455,308 + +0.8
455,308 + +1.2

Or see this region's nucleotide sequence