Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2378c

Experiment: L-Asparagine 10 mM (N)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2375 and Rv2376c are separated by 26 nucleotidesRv2376c and Rv2377c are separated by 99 nucleotidesRv2377c and Rv2378c overlap by 23 nucleotidesRv2378c and Rv2379c overlap by 4 nucleotides Rv2375: Rv2375 - Conserved hypothetical protein, at 2,655,265 to 2,655,582 Rv2375 Rv2376c: Rv2376c - Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2), at 2,655,609 to 2,656,115 Rv2376c Rv2377c: Rv2377c - Putative conserved protein MbtH, at 2,656,215 to 2,656,430 Rv2377c Rv2378c: Rv2378c - Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase), at 2,656,408 to 2,657,703 Rv2378c Rv2379c: Rv2379c - Peptide synthetase MbtF (peptide synthase), at 2,657,700 to 2,662,085 Rv2379c Position (kb) 2656 2657 2658Strain fitness (log2 ratio) -1 0 1at 2655.428 kb on - strand, within Rv2375at 2655.472 kb on + strand, within Rv2375at 2655.472 kb on + strand, within Rv2375at 2655.472 kb on + strand, within Rv2375at 2655.531 kb on - strand, within Rv2375at 2655.531 kb on - strand, within Rv2375at 2656.014 kb on + strand, within Rv2376cat 2656.015 kb on - strand, within Rv2376cat 2656.198 kb on + strandat 2656.279 kb on + strand, within Rv2377cat 2656.279 kb on + strand, within Rv2377cat 2657.006 kb on - strand, within Rv2378cat 2657.338 kb on + strand, within Rv2378cat 2657.338 kb on + strand, within Rv2378cat 2657.343 kb on - strand, within Rv2378cat 2657.436 kb on - strand, within Rv2378cat 2657.710 kb on - strandat 2657.898 kb on + strandat 2657.951 kb on - strandat 2658.095 kb on - strandat 2658.331 kb on - strand, within Rv2379c

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Per-strain Table

Position Strand Gene LocusTag Fraction L-Asparagine 10 mM (N)
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2,655,428 - Rv2375 0.51 +0.3
2,655,472 + Rv2375 0.65 -0.5
2,655,472 + Rv2375 0.65 -0.5
2,655,472 + Rv2375 0.65 -0.6
2,655,531 - Rv2375 0.84 -1.1
2,655,531 - Rv2375 0.84 -0.2
2,656,014 + Rv2376c 0.80 -0.6
2,656,015 - Rv2376c 0.80 -0.9
2,656,198 + -0.1
2,656,279 + Rv2377c 0.30 +0.1
2,656,279 + Rv2377c 0.30 -0.7
2,657,006 - Rv2378c 0.46 -1.6
2,657,338 + Rv2378c 0.72 -0.3
2,657,338 + Rv2378c 0.72 -0.5
2,657,343 - Rv2378c 0.72 -0.6
2,657,436 - Rv2378c 0.79 +0.1
2,657,710 - +0.6
2,657,898 + +0.3
2,657,951 - -1.6
2,658,095 - -1.4
2,658,331 - Rv2379c 0.14 -1.1

Or see this region's nucleotide sequence