Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1175c

Experiment: L-Asparagine 10 mM (N)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1173 and Rv1174c are separated by 167 nucleotidesRv1174c and Rv1175c are separated by 200 nucleotidesRv1175c and Rv1176c overlap by 4 nucleotidesRv1176c and Rv1177 are separated by 212 nucleotides Rv1173: Rv1173 - Probable F420 biosynthesis protein FbiC, at 1,302,931 to 1,305,501 Rv1173 Rv1174c: Rv1174c - Low molecular weight T-cell antigen TB8.4, at 1,305,669 to 1,306,001 Rv1174c Rv1175c: Rv1175c - Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase), at 1,306,202 to 1,308,226 Rv1175c Rv1176c: Rv1176c - Conserved hypothetical protein, at 1,308,223 to 1,308,792 Rv1176c Rv1177: Rv1177 - Probable ferredoxin FdxC, at 1,309,005 to 1,309,331 Rv1177 Position (kb) 1306 1307 1308 1309Strain fitness (log2 ratio) -1 0 1 2 3at 1305.236 kb on + strand, within Rv1173at 1305.236 kb on + strand, within Rv1173at 1305.481 kb on + strandat 1305.670 kb on + strandat 1305.670 kb on + strandat 1305.671 kb on - strandat 1305.673 kb on + strandat 1305.673 kb on + strandat 1305.673 kb on + strandat 1305.715 kb on + strand, within Rv1174cat 1305.715 kb on + strand, within Rv1174cat 1305.716 kb on - strand, within Rv1174cat 1305.716 kb on - strand, within Rv1174cat 1305.800 kb on - strand, within Rv1174cat 1305.867 kb on + strand, within Rv1174cat 1305.868 kb on - strand, within Rv1174cat 1305.870 kb on + strand, within Rv1174cat 1305.870 kb on + strand, within Rv1174cat 1305.870 kb on + strand, within Rv1174cat 1305.870 kb on + strand, within Rv1174cat 1305.870 kb on + strand, within Rv1174cat 1305.870 kb on + strand, within Rv1174cat 1305.871 kb on - strand, within Rv1174cat 1305.871 kb on - strand, within Rv1174cat 1305.871 kb on - strand, within Rv1174cat 1305.871 kb on - strand, within Rv1174cat 1305.896 kb on + strand, within Rv1174cat 1306.003 kb on + strandat 1306.004 kb on - strandat 1306.004 kb on - strandat 1306.004 kb on - strandat 1306.024 kb on - strandat 1306.024 kb on - strandat 1306.037 kb on + strandat 1306.037 kb on + strandat 1306.038 kb on - strandat 1306.144 kb on + strandat 1306.203 kb on + strandat 1306.205 kb on + strandat 1306.294 kb on + strandat 1306.295 kb on - strandat 1306.295 kb on - strandat 1306.359 kb on - strandat 1306.359 kb on - strandat 1306.416 kb on - strand, within Rv1175cat 1306.440 kb on + strand, within Rv1175cat 1306.554 kb on + strand, within Rv1175cat 1306.554 kb on + strand, within Rv1175cat 1306.771 kb on - strand, within Rv1175cat 1306.776 kb on - strand, within Rv1175cat 1306.997 kb on - strand, within Rv1175cat 1307.298 kb on - strand, within Rv1175cat 1307.560 kb on - strand, within Rv1175cat 1307.755 kb on - strand, within Rv1175cat 1307.892 kb on + strand, within Rv1175cat 1308.311 kb on + strand, within Rv1176cat 1308.311 kb on + strand, within Rv1176cat 1308.312 kb on - strand, within Rv1176cat 1308.426 kb on + strand, within Rv1176cat 1308.588 kb on - strand, within Rv1176cat 1308.589 kb on + strand, within Rv1176cat 1308.589 kb on + strand, within Rv1176cat 1308.589 kb on + strand, within Rv1176cat 1308.671 kb on + strand, within Rv1176cat 1308.672 kb on - strand, within Rv1176cat 1308.738 kb on - strandat 1308.831 kb on + strandat 1308.840 kb on - strandat 1308.840 kb on - strandat 1308.840 kb on - strandat 1308.850 kb on + strandat 1308.896 kb on - strandat 1308.898 kb on + strandat 1308.970 kb on + strandat 1308.970 kb on + strandat 1308.976 kb on + strandat 1308.976 kb on + strandat 1308.976 kb on + strandat 1308.976 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction L-Asparagine 10 mM (N)
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1,305,236 + Rv1173 0.90 +1.7
1,305,236 + Rv1173 0.90 +0.2
1,305,481 + +1.0
1,305,670 + -0.3
1,305,670 + +1.0
1,305,671 - -0.8
1,305,673 + -0.0
1,305,673 + +1.8
1,305,673 + +0.1
1,305,715 + Rv1174c 0.14 -0.2
1,305,715 + Rv1174c 0.14 -1.0
1,305,716 - Rv1174c 0.14 +0.0
1,305,716 - Rv1174c 0.14 +0.0
1,305,800 - Rv1174c 0.39 -0.1
1,305,867 + Rv1174c 0.59 +1.0
1,305,868 - Rv1174c 0.60 +0.7
1,305,870 + Rv1174c 0.60 -0.2
1,305,870 + Rv1174c 0.60 -0.1
1,305,870 + Rv1174c 0.60 -0.3
1,305,870 + Rv1174c 0.60 -0.4
1,305,870 + Rv1174c 0.60 -1.3
1,305,870 + Rv1174c 0.60 -0.4
1,305,871 - Rv1174c 0.61 -1.0
1,305,871 - Rv1174c 0.61 -0.4
1,305,871 - Rv1174c 0.61 -0.1
1,305,871 - Rv1174c 0.61 +0.5
1,305,896 + Rv1174c 0.68 +2.0
1,306,003 + +3.0
1,306,004 - -0.1
1,306,004 - +0.1
1,306,004 - -1.1
1,306,024 - -0.7
1,306,024 - +0.3
1,306,037 + -0.4
1,306,037 + -1.4
1,306,038 - +0.2
1,306,144 + -1.7
1,306,203 + -0.4
1,306,205 + +0.1
1,306,294 + -0.2
1,306,295 - +0.2
1,306,295 - +0.9
1,306,359 - -0.1
1,306,359 - +0.3
1,306,416 - Rv1175c 0.11 -0.2
1,306,440 + Rv1175c 0.12 -0.4
1,306,554 + Rv1175c 0.17 -0.4
1,306,554 + Rv1175c 0.17 -1.1
1,306,771 - Rv1175c 0.28 -0.3
1,306,776 - Rv1175c 0.28 -0.9
1,306,997 - Rv1175c 0.39 -0.3
1,307,298 - Rv1175c 0.54 +0.5
1,307,560 - Rv1175c 0.67 -0.2
1,307,755 - Rv1175c 0.77 -0.2
1,307,892 + Rv1175c 0.83 +1.2
1,308,311 + Rv1176c 0.15 +0.5
1,308,311 + Rv1176c 0.15 -0.5
1,308,312 - Rv1176c 0.16 -0.3
1,308,426 + Rv1176c 0.36 +0.0
1,308,588 - Rv1176c 0.64 +2.0
1,308,589 + Rv1176c 0.64 +1.1
1,308,589 + Rv1176c 0.64 +1.7
1,308,589 + Rv1176c 0.64 +0.5
1,308,671 + Rv1176c 0.79 +1.6
1,308,672 - Rv1176c 0.79 -0.5
1,308,738 - -0.5
1,308,831 + +0.7
1,308,840 - +0.0
1,308,840 - +1.0
1,308,840 - -0.1
1,308,850 + -1.1
1,308,896 - -0.5
1,308,898 + -0.1
1,308,970 + +0.2
1,308,970 + -0.3
1,308,976 + +0.2
1,308,976 + +0.4
1,308,976 + +1.0
1,308,976 + +0.1

Or see this region's nucleotide sequence