Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0445c

Experiment: Palmitic 100 uM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0443 and Rv0444c are separated by 179 nucleotidesRv0444c and Rv0445c are separated by 43 nucleotidesRv0445c and Rv0446c are separated by 48 nucleotidesRv0446c and Rv0447c are separated by 8 nucleotides Rv0443: Rv0443 - Conserved protein, at 532,396 to 532,911 Rv0443 Rv0444c: Rv0444c - Anti-sigma factor RskA (regulator of sigma K), at 533,091 to 533,789 Rv0444c Rv0445c: Rv0445c - Alternative RNA polymerase sigma factor SigK, at 533,833 to 534,396 Rv0445c Rv0446c: Rv0446c - Possible conserved transmembrane protein, at 534,445 to 535,215 Rv0446c Rv0447c: Rv0447c - Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (cyclopropane fatty acid synthase) (CFA synthase), at 535,224 to 536,507 Rv0447c Position (kb) 533 534 535Strain fitness (log2 ratio) -2 -1 0 1 2at 532.888 kb on + strandat 532.888 kb on + strandat 532.901 kb on + strandat 532.978 kb on - strandat 532.978 kb on - strandat 533.400 kb on + strand, within Rv0444cat 533.400 kb on + strand, within Rv0444cat 533.401 kb on - strand, within Rv0444cat 533.401 kb on - strand, within Rv0444cat 533.401 kb on - strand, within Rv0444cat 533.522 kb on + strand, within Rv0444cat 533.743 kb on + strandat 533.744 kb on - strandat 533.751 kb on - strandat 533.933 kb on + strand, within Rv0445cat 533.933 kb on + strand, within Rv0445cat 533.934 kb on - strand, within Rv0445cat 533.934 kb on - strand, within Rv0445cat 533.934 kb on - strand, within Rv0445cat 533.951 kb on + strand, within Rv0445cat 533.951 kb on + strand, within Rv0445cat 533.952 kb on - strand, within Rv0445cat 533.952 kb on - strand, within Rv0445cat 533.952 kb on - strand, within Rv0445cat 534.084 kb on - strand, within Rv0445cat 534.248 kb on + strand, within Rv0445cat 534.285 kb on - strand, within Rv0445cat 534.285 kb on - strand, within Rv0445cat 534.309 kb on - strand, within Rv0445cat 534.483 kb on - strandat 534.530 kb on + strand, within Rv0446cat 534.668 kb on + strand, within Rv0446cat 534.669 kb on - strand, within Rv0446cat 534.742 kb on + strand, within Rv0446cat 534.898 kb on + strand, within Rv0446cat 534.992 kb on + strand, within Rv0446cat 534.992 kb on + strand, within Rv0446cat 534.992 kb on + strand, within Rv0446cat 535.036 kb on + strand, within Rv0446cat 535.037 kb on - strand, within Rv0446cat 535.039 kb on + strand, within Rv0446cat 535.118 kb on - strand, within Rv0446cat 535.136 kb on + strand, within Rv0446cat 535.136 kb on + strand, within Rv0446cat 535.136 kb on + strand, within Rv0446cat 535.258 kb on + strandat 535.259 kb on - strandat 535.307 kb on - strandat 535.344 kb on + strandat 535.373 kb on + strand, within Rv0447cat 535.374 kb on - strand, within Rv0447c

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Per-strain Table

Position Strand Gene LocusTag Fraction Palmitic 100 uM (C)
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532,888 + +1.6
532,888 + -0.0
532,901 + -0.5
532,978 - +1.8
532,978 - -0.2
533,400 + Rv0444c 0.44 -0.2
533,400 + Rv0444c 0.44 -0.6
533,401 - Rv0444c 0.44 +0.1
533,401 - Rv0444c 0.44 -0.9
533,401 - Rv0444c 0.44 -2.2
533,522 + Rv0444c 0.62 -0.9
533,743 + -0.5
533,744 - -2.3
533,751 - -0.7
533,933 + Rv0445c 0.18 -0.4
533,933 + Rv0445c 0.18 +0.2
533,934 - Rv0445c 0.18 -1.2
533,934 - Rv0445c 0.18 -1.2
533,934 - Rv0445c 0.18 -0.3
533,951 + Rv0445c 0.21 -0.3
533,951 + Rv0445c 0.21 -0.8
533,952 - Rv0445c 0.21 -0.2
533,952 - Rv0445c 0.21 -0.7
533,952 - Rv0445c 0.21 +0.1
534,084 - Rv0445c 0.45 -0.5
534,248 + Rv0445c 0.74 -0.6
534,285 - Rv0445c 0.80 -0.0
534,285 - Rv0445c 0.80 -2.5
534,309 - Rv0445c 0.84 -0.7
534,483 - +0.1
534,530 + Rv0446c 0.11 -0.3
534,668 + Rv0446c 0.29 -0.2
534,669 - Rv0446c 0.29 -0.0
534,742 + Rv0446c 0.39 -0.2
534,898 + Rv0446c 0.59 -0.1
534,992 + Rv0446c 0.71 +0.2
534,992 + Rv0446c 0.71 -0.2
534,992 + Rv0446c 0.71 -1.0
535,036 + Rv0446c 0.77 -0.6
535,037 - Rv0446c 0.77 +0.7
535,039 + Rv0446c 0.77 +0.1
535,118 - Rv0446c 0.87 -0.9
535,136 + Rv0446c 0.90 -0.3
535,136 + Rv0446c 0.90 -0.3
535,136 + Rv0446c 0.90 -0.6
535,258 + +2.5
535,259 - -0.3
535,307 - +0.2
535,344 + -0.2
535,373 + Rv0447c 0.12 +2.5
535,374 - Rv0447c 0.12 -0.5

Or see this region's nucleotide sequence