Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0348

Experiment: Stearic 100 uM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0347 and Rv0348 are separated by 2 nucleotidesRv0348 and Rv0349 are separated by 2 nucleotidesRv0349 and Rv0350 are separated by 226 nucleotides Rv0347: Rv0347 - Probable conserved membrane protein, at 417,304 to 418,290 Rv0347 Rv0348: Rv0348 - Possible transcriptional regulatory protein, at 418,293 to 418,946 Rv0348 Rv0349: Rv0349 - Hypothetical protein, at 418,949 to 419,608 Rv0349 Rv0350: Rv0350 - Probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kDa protein) (HSP70), at 419,835 to 421,712 Rv0350 Position (kb) 418 419Strain fitness (log2 ratio) -1 0 1 2 3at 417.350 kb on + strandat 418.257 kb on + strandat 418.258 kb on - strandat 418.419 kb on + strand, within Rv0348at 418.840 kb on - strand, within Rv0348at 418.844 kb on - strand, within Rv0348at 418.860 kb on - strand, within Rv0348at 418.903 kb on - strandat 418.931 kb on - strandat 418.988 kb on + strandat 418.988 kb on + strandat 418.988 kb on + strandat 418.988 kb on + strandat 418.989 kb on - strandat 418.989 kb on - strandat 418.989 kb on - strandat 418.989 kb on - strandat 418.989 kb on - strandat 419.339 kb on + strand, within Rv0349at 419.339 kb on + strand, within Rv0349at 419.340 kb on - strand, within Rv0349at 419.340 kb on - strand, within Rv0349at 419.375 kb on + strand, within Rv0349at 419.376 kb on - strand, within Rv0349at 419.560 kb on - strandat 419.646 kb on + strandat 419.646 kb on + strandat 419.647 kb on - strandat 419.647 kb on - strandat 419.647 kb on - strandat 419.703 kb on + strandat 419.703 kb on + strandat 419.716 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction Stearic 100 uM (C)
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417,350 + -0.5
418,257 + +0.8
418,258 - -1.6
418,419 + Rv0348 0.19 -0.9
418,840 - Rv0348 0.84 -0.3
418,844 - Rv0348 0.84 -1.5
418,860 - Rv0348 0.87 +0.5
418,903 - -0.2
418,931 - -0.5
418,988 + -0.0
418,988 + +2.9
418,988 + +1.9
418,988 + -1.3
418,989 - -0.8
418,989 - +0.9
418,989 - -0.5
418,989 - +0.3
418,989 - +0.1
419,339 + Rv0349 0.59 -0.9
419,339 + Rv0349 0.59 +0.0
419,340 - Rv0349 0.59 -1.1
419,340 - Rv0349 0.59 +0.1
419,375 + Rv0349 0.65 +0.1
419,376 - Rv0349 0.65 +1.0
419,560 - +0.0
419,646 + +2.7
419,646 + +0.3
419,647 - +0.0
419,647 - -0.6
419,647 - -0.4
419,703 + +0.3
419,703 + +1.6
419,716 - -0.6

Or see this region's nucleotide sequence