Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0444c

Experiment: Stearic 100 uM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0442c and Rv0443 are separated by 181 nucleotidesRv0443 and Rv0444c are separated by 179 nucleotidesRv0444c and Rv0445c are separated by 43 nucleotidesRv0445c and Rv0446c are separated by 48 nucleotides Rv0442c: Rv0442c - PPE family protein PPE10, at 530,751 to 532,214 Rv0442c Rv0443: Rv0443 - Conserved protein, at 532,396 to 532,911 Rv0443 Rv0444c: Rv0444c - Anti-sigma factor RskA (regulator of sigma K), at 533,091 to 533,789 Rv0444c Rv0445c: Rv0445c - Alternative RNA polymerase sigma factor SigK, at 533,833 to 534,396 Rv0445c Rv0446c: Rv0446c - Possible conserved transmembrane protein, at 534,445 to 535,215 Rv0446c Position (kb) 533 534Strain fitness (log2 ratio) -1 0 1 2at 532.267 kb on + strandat 532.267 kb on + strandat 532.267 kb on + strandat 532.267 kb on + strandat 532.318 kb on + strandat 532.318 kb on + strandat 532.319 kb on - strandat 532.322 kb on + strandat 532.323 kb on - strandat 532.323 kb on - strandat 532.395 kb on + strandat 532.396 kb on - strandat 532.396 kb on - strandat 532.569 kb on + strand, within Rv0443at 532.570 kb on - strand, within Rv0443at 532.570 kb on - strand, within Rv0443at 532.571 kb on + strand, within Rv0443at 532.572 kb on - strand, within Rv0443at 532.572 kb on - strand, within Rv0443at 532.641 kb on - strand, within Rv0443at 532.667 kb on - strand, within Rv0443at 532.727 kb on - strand, within Rv0443at 532.729 kb on + strand, within Rv0443at 532.744 kb on - strand, within Rv0443at 532.744 kb on - strand, within Rv0443at 532.759 kb on + strand, within Rv0443at 532.760 kb on - strand, within Rv0443at 532.760 kb on - strand, within Rv0443at 532.888 kb on + strandat 532.888 kb on + strandat 532.901 kb on + strandat 532.978 kb on - strandat 532.978 kb on - strandat 533.400 kb on + strand, within Rv0444cat 533.400 kb on + strand, within Rv0444cat 533.401 kb on - strand, within Rv0444cat 533.401 kb on - strand, within Rv0444cat 533.401 kb on - strand, within Rv0444cat 533.522 kb on + strand, within Rv0444cat 533.743 kb on + strandat 533.744 kb on - strandat 533.751 kb on - strandat 533.933 kb on + strand, within Rv0445cat 533.933 kb on + strand, within Rv0445cat 533.934 kb on - strand, within Rv0445cat 533.934 kb on - strand, within Rv0445cat 533.951 kb on + strand, within Rv0445cat 533.951 kb on + strand, within Rv0445cat 533.952 kb on - strand, within Rv0445cat 533.952 kb on - strand, within Rv0445cat 533.952 kb on - strand, within Rv0445cat 533.952 kb on - strand, within Rv0445cat 534.084 kb on - strand, within Rv0445cat 534.248 kb on + strand, within Rv0445cat 534.285 kb on - strand, within Rv0445cat 534.285 kb on - strand, within Rv0445cat 534.309 kb on - strand, within Rv0445cat 534.483 kb on - strandat 534.530 kb on + strand, within Rv0446cat 534.668 kb on + strand, within Rv0446cat 534.669 kb on - strand, within Rv0446cat 534.742 kb on + strand, within Rv0446c

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Per-strain Table

Position Strand Gene LocusTag Fraction Stearic 100 uM (C)
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532,267 + +0.2
532,267 + -0.5
532,267 + -0.5
532,267 + -0.4
532,318 + -1.2
532,318 + -0.6
532,319 - -0.2
532,322 + +0.0
532,323 - +0.5
532,323 - -0.3
532,395 + -0.2
532,396 - +0.3
532,396 - +0.6
532,569 + Rv0443 0.34 -0.3
532,570 - Rv0443 0.34 +2.1
532,570 - Rv0443 0.34 -0.5
532,571 + Rv0443 0.34 +0.2
532,572 - Rv0443 0.34 -0.4
532,572 - Rv0443 0.34 -0.9
532,641 - Rv0443 0.47 +0.3
532,667 - Rv0443 0.53 -0.8
532,727 - Rv0443 0.64 -0.2
532,729 + Rv0443 0.65 -0.1
532,744 - Rv0443 0.67 -0.1
532,744 - Rv0443 0.67 -0.5
532,759 + Rv0443 0.70 -0.6
532,760 - Rv0443 0.71 -0.1
532,760 - Rv0443 0.71 +0.0
532,888 + -0.2
532,888 + -0.4
532,901 + -0.5
532,978 - +2.4
532,978 - +0.0
533,400 + Rv0444c 0.44 -1.3
533,400 + Rv0444c 0.44 -0.9
533,401 - Rv0444c 0.44 -1.7
533,401 - Rv0444c 0.44 -0.9
533,401 - Rv0444c 0.44 -0.2
533,522 + Rv0444c 0.62 -1.4
533,743 + -1.1
533,744 - -0.3
533,751 - -0.2
533,933 + Rv0445c 0.18 -0.5
533,933 + Rv0445c 0.18 -0.3
533,934 - Rv0445c 0.18 +0.8
533,934 - Rv0445c 0.18 -0.2
533,951 + Rv0445c 0.21 +0.1
533,951 + Rv0445c 0.21 -0.6
533,952 - Rv0445c 0.21 +1.8
533,952 - Rv0445c 0.21 +0.3
533,952 - Rv0445c 0.21 -0.5
533,952 - Rv0445c 0.21 -0.3
534,084 - Rv0445c 0.45 -0.7
534,248 + Rv0445c 0.74 -0.3
534,285 - Rv0445c 0.80 -0.6
534,285 - Rv0445c 0.80 +0.3
534,309 - Rv0445c 0.84 -0.3
534,483 - +0.1
534,530 + Rv0446c 0.11 -0.0
534,668 + Rv0446c 0.29 -0.1
534,669 - Rv0446c 0.29 -1.1
534,742 + Rv0446c 0.39 -0.4

Or see this region's nucleotide sequence