Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0539

Experiment: butyrate 10 mM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0538 and Rv0539 are separated by 56 nucleotidesRv0539 and Rv0540 overlap by 4 nucleotidesRv0540 and Rv0541c are separated by 20 nucleotides Rv0538: Rv0538 - Possible conserved membrane protein, at 630,040 to 631,686 Rv0538 Rv0539: Rv0539 - Probable dolichyl-phosphate sugar synthase (dolichol-phosphate sugar synthetase) (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase), at 631,743 to 632,375 Rv0539 Rv0540: Rv0540 - Conserved hypothetical protein, at 632,372 to 633,034 Rv0540 Rv0541c: Rv0541c - Probable conserved integral membrane protein, at 633,055 to 634,404 Rv0541c Position (kb) 631 632 633Strain fitness (log2 ratio) -1 0 1at 630.766 kb on + strand, within Rv0538at 630.767 kb on - strand, within Rv0538at 630.784 kb on + strand, within Rv0538at 630.784 kb on + strand, within Rv0538at 630.826 kb on + strand, within Rv0538at 630.827 kb on - strand, within Rv0538at 631.670 kb on + strandat 631.670 kb on + strandat 631.670 kb on + strandat 631.670 kb on + strandat 631.670 kb on + strandat 632.283 kb on + strand, within Rv0539at 632.284 kb on - strand, within Rv0539at 632.552 kb on - strand, within Rv0540at 632.602 kb on + strand, within Rv0540at 632.603 kb on - strand, within Rv0540at 632.827 kb on + strand, within Rv0540at 632.827 kb on + strand, within Rv0540at 633.057 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction butyrate 10 mM (C)
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630,766 + Rv0538 0.44 -0.2
630,767 - Rv0538 0.44 -0.0
630,784 + Rv0538 0.45 -0.4
630,784 + Rv0538 0.45 -0.4
630,826 + Rv0538 0.48 -0.6
630,827 - Rv0538 0.48 -0.1
631,670 + +0.3
631,670 + -0.0
631,670 + +0.6
631,670 + +0.9
631,670 + -0.1
632,283 + Rv0539 0.85 -1.0
632,284 - Rv0539 0.85 -0.8
632,552 - Rv0540 0.27 -0.8
632,602 + Rv0540 0.35 +1.0
632,603 - Rv0540 0.35 +0.9
632,827 + Rv0540 0.69 +1.0
632,827 + Rv0540 0.69 -1.2
633,057 - +0.3

Or see this region's nucleotide sequence