Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2318

Experiment: Valeric 10 mM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2316 and Rv2317 overlap by 14 nucleotidesRv2317 and Rv2318 overlap by 4 nucleotidesRv2318 and Rv2319c are separated by 7 nucleotidesRv2319c and Rv2320c overlap by 4 nucleotides Rv2316: Rv2316 - Probable sugar-transport integral membrane protein ABC transporter UspA, at 2,588,838 to 2,589,710 Rv2316 Rv2317: Rv2317 - Probable sugar-transport integral membrane protein ABC transporter UspB, at 2,589,697 to 2,590,521 Rv2317 Rv2318: Rv2318 - Probable periplasmic sugar-binding lipoprotein UspC, at 2,590,518 to 2,591,840 Rv2318 Rv2319c: Rv2319c - Universal stress protein family protein, at 2,591,848 to 2,592,726 Rv2319c Rv2320c: Rv2320c - Probable cationic amino acid transport integral membrane protein RocE, at 2,592,723 to 2,594,153 Rv2320c Position (kb) 2590 2591 2592Strain fitness (log2 ratio) -1 0 1 2at 2589.676 kb on - strandat 2589.709 kb on - strandat 2590.025 kb on - strand, within Rv2317at 2590.640 kb on - strandat 2590.836 kb on + strand, within Rv2318at 2591.187 kb on + strand, within Rv2318at 2591.391 kb on + strand, within Rv2318at 2591.392 kb on - strand, within Rv2318at 2591.839 kb on - strandat 2591.918 kb on - strandat 2592.288 kb on - strand, within Rv2319cat 2592.479 kb on + strand, within Rv2319cat 2592.480 kb on - strand, within Rv2319cat 2592.480 kb on - strand, within Rv2319cat 2592.671 kb on - strandat 2592.676 kb on + strandat 2592.676 kb on + strandat 2592.677 kb on - strandat 2592.707 kb on + strandat 2592.821 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction Valeric 10 mM (C)
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2,589,676 - -0.0
2,589,709 - +0.8
2,590,025 - Rv2317 0.40 -0.9
2,590,640 - +1.3
2,590,836 + Rv2318 0.24 +0.0
2,591,187 + Rv2318 0.51 -1.2
2,591,391 + Rv2318 0.66 +0.5
2,591,392 - Rv2318 0.66 -1.1
2,591,839 - -0.1
2,591,918 - -1.3
2,592,288 - Rv2319c 0.50 -0.5
2,592,479 + Rv2319c 0.72 -0.1
2,592,480 - Rv2319c 0.72 -0.6
2,592,480 - Rv2319c 0.72 -0.2
2,592,671 - -0.1
2,592,676 + +1.9
2,592,676 + -0.7
2,592,677 - -0.5
2,592,707 + -0.5
2,592,821 - +0.2

Or see this region's nucleotide sequence