Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1781c

Experiment: D-Trehalose 10 mM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1779c and Rv1780 are separated by 219 nucleotidesRv1780 and Rv1781c are separated by 39 nucleotidesRv1781c and Rv1782 are separated by 263 nucleotides Rv1779c: Rv1779c - Possible integral membrane protein, at 2,012,686 to 2,014,479 Rv1779c Rv1780: Rv1780 - Conserved protein, at 2,014,699 to 2,015,262 Rv1780 Rv1781c: Rv1781c - Probable 4-alpha-glucanotransferase MalQ (amylomaltase) (disproportionating enzyme) (D-enzyme), at 2,015,302 to 2,017,476 Rv1781c Rv1782: Rv1782 - ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein., at 2,017,740 to 2,019,260 Rv1782 Position (kb) 2015 2016 2017 2018Strain fitness (log2 ratio) -1 0 1 2at 2014.419 kb on + strandat 2014.419 kb on + strandat 2014.420 kb on - strandat 2014.420 kb on - strandat 2014.420 kb on - strandat 2014.464 kb on - strandat 2014.690 kb on + strandat 2014.691 kb on - strandat 2014.691 kb on - strandat 2014.692 kb on + strandat 2014.692 kb on + strandat 2014.692 kb on + strandat 2014.692 kb on + strandat 2014.693 kb on - strandat 2014.693 kb on - strandat 2014.698 kb on + strandat 2014.698 kb on + strandat 2014.698 kb on + strandat 2014.698 kb on + strandat 2014.699 kb on - strandat 2014.720 kb on - strandat 2014.762 kb on - strand, within Rv1780at 2014.762 kb on - strand, within Rv1780at 2015.039 kb on + strand, within Rv1780at 2015.040 kb on - strand, within Rv1780at 2015.074 kb on + strand, within Rv1780at 2015.170 kb on + strand, within Rv1780at 2015.170 kb on + strand, within Rv1780at 2015.171 kb on - strand, within Rv1780at 2015.244 kb on + strandat 2015.245 kb on - strandat 2015.535 kb on - strand, within Rv1781cat 2015.535 kb on - strand, within Rv1781cat 2015.540 kb on + strand, within Rv1781cat 2015.672 kb on - strand, within Rv1781cat 2015.699 kb on - strand, within Rv1781cat 2015.699 kb on - strand, within Rv1781cat 2015.718 kb on - strand, within Rv1781cat 2015.718 kb on - strand, within Rv1781cat 2015.863 kb on + strand, within Rv1781cat 2015.864 kb on - strand, within Rv1781cat 2015.864 kb on - strand, within Rv1781cat 2015.866 kb on + strand, within Rv1781cat 2015.866 kb on + strand, within Rv1781cat 2015.870 kb on + strand, within Rv1781cat 2015.870 kb on + strand, within Rv1781cat 2015.871 kb on - strand, within Rv1781cat 2015.871 kb on - strand, within Rv1781cat 2015.984 kb on + strand, within Rv1781cat 2015.984 kb on + strand, within Rv1781cat 2015.984 kb on + strand, within Rv1781cat 2015.984 kb on + strand, within Rv1781cat 2015.984 kb on + strand, within Rv1781cat 2015.984 kb on + strand, within Rv1781cat 2015.985 kb on - strand, within Rv1781cat 2015.985 kb on - strand, within Rv1781cat 2015.985 kb on - strand, within Rv1781cat 2015.985 kb on - strand, within Rv1781cat 2015.985 kb on - strand, within Rv1781cat 2015.985 kb on - strand, within Rv1781cat 2015.985 kb on - strand, within Rv1781cat 2015.985 kb on - strand, within Rv1781cat 2015.985 kb on - strand, within Rv1781cat 2016.110 kb on + strand, within Rv1781cat 2016.533 kb on + strand, within Rv1781cat 2016.761 kb on + strand, within Rv1781cat 2016.761 kb on + strand, within Rv1781cat 2016.762 kb on - strand, within Rv1781cat 2016.839 kb on + strand, within Rv1781cat 2017.374 kb on + strandat 2017.569 kb on - strandat 2017.588 kb on + strandat 2017.636 kb on + strandat 2017.636 kb on + strandat 2017.637 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction D-Trehalose 10 mM (C)
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2,014,419 + -0.2
2,014,419 + -0.4
2,014,420 - -0.2
2,014,420 - -0.5
2,014,420 - -0.6
2,014,464 - +0.4
2,014,690 + +0.3
2,014,691 - +1.5
2,014,691 - -1.1
2,014,692 + -0.9
2,014,692 + -0.5
2,014,692 + -0.3
2,014,692 + -0.3
2,014,693 - +0.3
2,014,693 - -0.0
2,014,698 + +1.8
2,014,698 + -1.0
2,014,698 + -1.0
2,014,698 + +0.8
2,014,699 - -0.4
2,014,720 - -0.9
2,014,762 - Rv1780 0.11 +0.8
2,014,762 - Rv1780 0.11 -1.3
2,015,039 + Rv1780 0.60 -0.3
2,015,040 - Rv1780 0.60 -0.0
2,015,074 + Rv1780 0.66 -0.1
2,015,170 + Rv1780 0.84 -1.0
2,015,170 + Rv1780 0.84 +1.4
2,015,171 - Rv1780 0.84 +0.1
2,015,244 + -0.6
2,015,245 - +0.3
2,015,535 - Rv1781c 0.11 -0.0
2,015,535 - Rv1781c 0.11 -0.6
2,015,540 + Rv1781c 0.11 -0.1
2,015,672 - Rv1781c 0.17 +1.0
2,015,699 - Rv1781c 0.18 -0.9
2,015,699 - Rv1781c 0.18 -1.6
2,015,718 - Rv1781c 0.19 -0.7
2,015,718 - Rv1781c 0.19 +0.1
2,015,863 + Rv1781c 0.26 -0.4
2,015,864 - Rv1781c 0.26 -0.8
2,015,864 - Rv1781c 0.26 -0.5
2,015,866 + Rv1781c 0.26 +0.1
2,015,866 + Rv1781c 0.26 -0.1
2,015,870 + Rv1781c 0.26 +0.1
2,015,870 + Rv1781c 0.26 -1.4
2,015,871 - Rv1781c 0.26 -0.4
2,015,871 - Rv1781c 0.26 -0.2
2,015,984 + Rv1781c 0.31 +0.9
2,015,984 + Rv1781c 0.31 +0.1
2,015,984 + Rv1781c 0.31 -0.3
2,015,984 + Rv1781c 0.31 -0.5
2,015,984 + Rv1781c 0.31 -0.7
2,015,984 + Rv1781c 0.31 +1.3
2,015,985 - Rv1781c 0.31 -0.4
2,015,985 - Rv1781c 0.31 -0.2
2,015,985 - Rv1781c 0.31 -0.7
2,015,985 - Rv1781c 0.31 -0.3
2,015,985 - Rv1781c 0.31 +0.4
2,015,985 - Rv1781c 0.31 -0.4
2,015,985 - Rv1781c 0.31 -0.1
2,015,985 - Rv1781c 0.31 -0.3
2,015,985 - Rv1781c 0.31 -0.2
2,016,110 + Rv1781c 0.37 -0.0
2,016,533 + Rv1781c 0.57 -0.7
2,016,761 + Rv1781c 0.67 -0.6
2,016,761 + Rv1781c 0.67 -0.4
2,016,762 - Rv1781c 0.67 +0.5
2,016,839 + Rv1781c 0.71 -0.5
2,017,374 + -0.2
2,017,569 - -0.4
2,017,588 + -1.3
2,017,636 + +1.2
2,017,636 + -0.2
2,017,637 - -0.2

Or see this region's nucleotide sequence