Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1849

Experiment: D,L-Malic Acid 10 mM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1847 and Rv1848 are separated by 48 nucleotidesRv1848 and Rv1849 overlap by 4 nucleotidesRv1849 and Rv1850 overlap by 1 nucleotides Rv1847: Rv1847 - Conserved protein, at 2,096,877 to 2,097,299 Rv1847 Rv1848: Rv1848 - Urease gamma subunit UreA (urea amidohydrolase), at 2,097,348 to 2,097,650 Rv1848 Rv1849: Rv1849 - Urease beta subunit UreB (urea amidohydrolase), at 2,097,647 to 2,097,961 Rv1849 Rv1850: Rv1850 - Urease alpha subunit UreC (urea amidohydrolase), at 2,097,961 to 2,099,694 Rv1850 Position (kb) 2097 2098Strain fitness (log2 ratio) -2 -1 0 1 2 3at 2096.689 kb on + strandat 2096.689 kb on + strandat 2096.689 kb on + strandat 2096.690 kb on - strandat 2096.690 kb on - strandat 2096.690 kb on - strandat 2096.690 kb on - strandat 2096.711 kb on + strandat 2096.712 kb on - strandat 2096.864 kb on + strandat 2096.865 kb on - strandat 2097.040 kb on - strand, within Rv1847at 2097.131 kb on + strand, within Rv1847at 2097.131 kb on + strand, within Rv1847at 2097.131 kb on + strand, within Rv1847at 2097.132 kb on - strand, within Rv1847at 2097.172 kb on - strand, within Rv1847at 2097.172 kb on - strand, within Rv1847at 2097.172 kb on - strand, within Rv1847at 2097.172 kb on - strand, within Rv1847at 2097.986 kb on - strandat 2097.998 kb on - strandat 2098.005 kb on + strandat 2098.005 kb on + strandat 2098.006 kb on - strandat 2098.837 kb on - strand, within Rv1850at 2098.860 kb on - strand, within Rv1850at 2098.860 kb on - strand, within Rv1850

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Per-strain Table

Position Strand Gene LocusTag Fraction D,L-Malic Acid 10 mM (C)
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2,096,689 + +1.1
2,096,689 + -1.0
2,096,689 + -0.5
2,096,690 - +0.6
2,096,690 - +0.3
2,096,690 - +2.9
2,096,690 - +0.2
2,096,711 + -0.9
2,096,712 - -0.2
2,096,864 + -0.8
2,096,865 - -0.5
2,097,040 - Rv1847 0.39 -0.5
2,097,131 + Rv1847 0.60 -0.4
2,097,131 + Rv1847 0.60 -0.3
2,097,131 + Rv1847 0.60 -0.5
2,097,132 - Rv1847 0.60 -0.4
2,097,172 - Rv1847 0.70 +0.4
2,097,172 - Rv1847 0.70 -0.3
2,097,172 - Rv1847 0.70 -0.5
2,097,172 - Rv1847 0.70 -0.2
2,097,986 - -0.2
2,097,998 - -0.6
2,098,005 + +1.6
2,098,005 + -1.0
2,098,006 - -2.3
2,098,837 - Rv1850 0.51 +0.9
2,098,860 - Rv1850 0.52 -1.2
2,098,860 - Rv1850 0.52 +0.1

Or see this region's nucleotide sequence