Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3339c

Experiment: D,L-Malic Acid 10 mM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3336c and Rv3337 are separated by 24 nucleotidesRv3337 and Rv3338 overlap by 139 nucleotidesRv3338 and Rv3339c are separated by 66 nucleotidesRv3339c and Rv3340 are separated by 282 nucleotides Rv3336c: Rv3336c - Probable tryptophanyl-tRNA synthetase TrpS (tryptophan--tRNA ligase) (TRPRS) (tryptophan translase), at 3,722,621 to 3,723,631 Rv3336c Rv3337: Rv3337 - Conserved hypothetical protein, at 3,723,656 to 3,724,042 Rv3337 Rv3338: Rv3338 - Conserved hypothetical protein, at 3,723,904 to 3,724,548 Rv3338 Rv3339c: Rv3339c - Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP), at 3,724,615 to 3,725,844 Rv3339c Rv3340: Rv3340 - Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase), at 3,726,127 to 3,727,476 Rv3340 Position (kb) 3724 3725 3726Strain fitness (log2 ratio) -2 -1 0 1 2at 3723.715 kb on + strand, within Rv3337at 3723.727 kb on + strand, within Rv3337at 3723.728 kb on - strand, within Rv3337at 3723.769 kb on - strand, within Rv3337at 3723.774 kb on + strand, within Rv3337at 3723.774 kb on + strand, within Rv3337at 3723.774 kb on + strand, within Rv3337at 3723.775 kb on - strand, within Rv3337at 3723.849 kb on + strand, within Rv3337at 3723.849 kb on + strand, within Rv3337at 3723.849 kb on + strand, within Rv3337at 3723.850 kb on - strand, within Rv3337at 3723.973 kb on - strandat 3723.973 kb on - strandat 3724.105 kb on - strand, within Rv3338at 3724.277 kb on - strand, within Rv3338at 3724.547 kb on - strandat 3724.547 kb on - strandat 3724.816 kb on + strand, within Rv3339cat 3724.817 kb on - strand, within Rv3339cat 3724.881 kb on - strand, within Rv3339cat 3724.881 kb on - strand, within Rv3339cat 3724.890 kb on - strand, within Rv3339cat 3724.982 kb on + strand, within Rv3339cat 3724.982 kb on + strand, within Rv3339cat 3725.021 kb on + strand, within Rv3339cat 3725.099 kb on + strand, within Rv3339cat 3725.100 kb on - strand, within Rv3339cat 3725.144 kb on + strand, within Rv3339cat 3725.213 kb on + strand, within Rv3339cat 3725.213 kb on + strand, within Rv3339cat 3725.213 kb on + strand, within Rv3339cat 3725.214 kb on - strand, within Rv3339cat 3725.214 kb on - strand, within Rv3339cat 3725.214 kb on - strand, within Rv3339cat 3725.216 kb on - strand, within Rv3339cat 3725.289 kb on - strand, within Rv3339cat 3725.289 kb on - strand, within Rv3339cat 3725.420 kb on + strand, within Rv3339cat 3725.712 kb on - strand, within Rv3339cat 3725.712 kb on - strand, within Rv3339cat 3725.803 kb on + strandat 3725.824 kb on + strandat 3725.863 kb on - strandat 3725.865 kb on + strandat 3725.866 kb on - strandat 3725.866 kb on - strandat 3725.885 kb on + strandat 3725.944 kb on + strandat 3725.945 kb on - strandat 3725.945 kb on - strandat 3726.058 kb on + strandat 3726.502 kb on + strand, within Rv3340

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Per-strain Table

Position Strand Gene LocusTag Fraction D,L-Malic Acid 10 mM (C)
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3,723,715 + Rv3337 0.15 -1.2
3,723,727 + Rv3337 0.18 -0.8
3,723,728 - Rv3337 0.19 -0.6
3,723,769 - Rv3337 0.29 +0.3
3,723,774 + Rv3337 0.30 +0.2
3,723,774 + Rv3337 0.30 +0.5
3,723,774 + Rv3337 0.30 -0.6
3,723,775 - Rv3337 0.31 -0.0
3,723,849 + Rv3337 0.50 +0.1
3,723,849 + Rv3337 0.50 -0.0
3,723,849 + Rv3337 0.50 -2.1
3,723,850 - Rv3337 0.50 +0.0
3,723,973 - -0.3
3,723,973 - -2.0
3,724,105 - Rv3338 0.31 -0.1
3,724,277 - Rv3338 0.58 -0.4
3,724,547 - -0.3
3,724,547 - +0.1
3,724,816 + Rv3339c 0.16 -1.1
3,724,817 - Rv3339c 0.16 -1.9
3,724,881 - Rv3339c 0.22 +0.6
3,724,881 - Rv3339c 0.22 +0.2
3,724,890 - Rv3339c 0.22 +0.6
3,724,982 + Rv3339c 0.30 -0.1
3,724,982 + Rv3339c 0.30 -0.3
3,725,021 + Rv3339c 0.33 -2.0
3,725,099 + Rv3339c 0.39 +0.0
3,725,100 - Rv3339c 0.39 +1.8
3,725,144 + Rv3339c 0.43 -0.1
3,725,213 + Rv3339c 0.49 +1.6
3,725,213 + Rv3339c 0.49 +0.3
3,725,213 + Rv3339c 0.49 +0.7
3,725,214 - Rv3339c 0.49 +0.2
3,725,214 - Rv3339c 0.49 -0.4
3,725,214 - Rv3339c 0.49 +0.0
3,725,216 - Rv3339c 0.49 -0.2
3,725,289 - Rv3339c 0.55 -0.0
3,725,289 - Rv3339c 0.55 +1.3
3,725,420 + Rv3339c 0.65 -0.6
3,725,712 - Rv3339c 0.89 -0.1
3,725,712 - Rv3339c 0.89 +1.2
3,725,803 + -0.1
3,725,824 + -0.8
3,725,863 - +1.8
3,725,865 + -0.5
3,725,866 - -0.2
3,725,866 - -0.2
3,725,885 + -0.1
3,725,944 + -0.6
3,725,945 - -1.4
3,725,945 - -0.8
3,726,058 + +0.3
3,726,502 + Rv3340 0.28 -1.6

Or see this region's nucleotide sequence