Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0958

Experiment: D,L-Malic Acid 10 mM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0957 and Rv0958 are separated by 106 nucleotidesRv0958 and Rv0959 overlap by 8 nucleotides Rv0957: Rv0957 - Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase) (5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase) + inosinemonophosphate cyclohydrolase (imp cyclohydrolase) (inosinicase) (imp synthetase) (ATIC), at 1,068,205 to 1,069,776 Rv0957 Rv0958: Rv0958 - Possible magnesium chelatase, at 1,069,883 to 1,071,262 Rv0958 Rv0959: Rv0959 - Conserved hypothetical protein, at 1,071,255 to 1,073,273 Rv0959 Position (kb) 1069 1070 1071 1072Strain fitness (log2 ratio) -1 0 1 2at 1069.869 kb on - strandat 1069.894 kb on + strandat 1069.894 kb on + strandat 1070.192 kb on + strand, within Rv0958at 1070.193 kb on - strand, within Rv0958at 1070.248 kb on - strand, within Rv0958at 1070.248 kb on - strand, within Rv0958at 1070.279 kb on + strand, within Rv0958at 1070.570 kb on + strand, within Rv0958at 1070.570 kb on + strand, within Rv0958at 1070.708 kb on + strand, within Rv0958at 1071.206 kb on + strandat 1071.207 kb on - strandat 1071.260 kb on + strandat 1071.328 kb on + strandat 1071.328 kb on + strandat 1071.329 kb on - strandat 1071.333 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction D,L-Malic Acid 10 mM (C)
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1,069,869 - +0.7
1,069,894 + +0.1
1,069,894 + -0.4
1,070,192 + Rv0958 0.22 -0.0
1,070,193 - Rv0958 0.22 -0.3
1,070,248 - Rv0958 0.26 +0.1
1,070,248 - Rv0958 0.26 +0.4
1,070,279 + Rv0958 0.29 -0.5
1,070,570 + Rv0958 0.50 +0.1
1,070,570 + Rv0958 0.50 +0.2
1,070,708 + Rv0958 0.60 +2.5
1,071,206 + -0.7
1,071,207 - -0.7
1,071,260 + +0.5
1,071,328 + +0.4
1,071,328 + +0.3
1,071,329 - -0.1
1,071,333 + -0.5

Or see this region's nucleotide sequence