Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2248

Experiment: L-Lactate 10 mM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2247 and Rv2248 are separated by 195 nucleotidesRv2248 and Rv2249c are separated by 65 nucleotides Rv2247: Rv2247 - Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6, at 2,520,743 to 2,522,164 Rv2247 Rv2248: Rv2248 - Conserved hypothetical protein, at 2,522,360 to 2,523,175 Rv2248 Rv2249c: Rv2249c - Probable glycerol-3-phosphate dehydrogenase GlpD1, at 2,523,241 to 2,524,791 Rv2249c Position (kb) 2522 2523 2524Strain fitness (log2 ratio) -2 -1 0 1 2at 2522.162 kb on + strandat 2522.304 kb on + strandat 2522.578 kb on - strand, within Rv2248at 2522.736 kb on + strand, within Rv2248at 2522.827 kb on - strand, within Rv2248at 2523.328 kb on - strandat 2523.620 kb on + strand, within Rv2249cat 2523.742 kb on + strand, within Rv2249cat 2523.762 kb on - strand, within Rv2249cat 2523.816 kb on + strand, within Rv2249c

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Per-strain Table

Position Strand Gene LocusTag Fraction L-Lactate 10 mM (C)
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2,522,162 + -0.4
2,522,304 + +1.9
2,522,578 - Rv2248 0.27 -0.9
2,522,736 + Rv2248 0.46 -2.4
2,522,827 - Rv2248 0.57 -0.1
2,523,328 - -0.2
2,523,620 + Rv2249c 0.24 -0.2
2,523,742 + Rv2249c 0.32 -0.2
2,523,762 - Rv2249c 0.34 +0.7
2,523,816 + Rv2249c 0.37 -0.5

Or see this region's nucleotide sequence