Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2027c

Experiment: D-Lactate 10 mM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2026c and Rv2027c are separated by 39 nucleotidesRv2027c and Rv2028c are separated by 60 nucleotidesRv2028c and Rv2029c overlap by 4 nucleotides Rv2026c: Rv2026c - Universal stress protein family protein, at 2,271,863 to 2,272,747 Rv2026c Rv2027c: Rv2027c - Two component sensor histidine kinase DosT, at 2,272,787 to 2,274,508 Rv2027c Rv2028c: Rv2028c - Universal stress protein family protein, at 2,274,569 to 2,275,408 Rv2028c Rv2029c: Rv2029c - 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase), at 2,275,405 to 2,276,424 Rv2029c Position (kb) 2272 2273 2274 2275Strain fitness (log2 ratio) -2 -1 0 1at 2271.864 kb on + strandat 2271.864 kb on + strandat 2271.864 kb on + strandat 2271.865 kb on - strandat 2271.865 kb on - strandat 2271.865 kb on - strandat 2272.060 kb on - strand, within Rv2026cat 2272.298 kb on - strand, within Rv2026cat 2273.241 kb on + strand, within Rv2027cat 2273.241 kb on + strand, within Rv2027cat 2273.242 kb on - strand, within Rv2027cat 2273.242 kb on - strand, within Rv2027cat 2273.449 kb on + strand, within Rv2027cat 2273.450 kb on - strand, within Rv2027cat 2273.608 kb on + strand, within Rv2027cat 2273.609 kb on - strand, within Rv2027cat 2273.697 kb on - strand, within Rv2027cat 2273.697 kb on - strand, within Rv2027cat 2273.697 kb on - strand, within Rv2027cat 2274.003 kb on + strand, within Rv2027cat 2274.003 kb on + strand, within Rv2027cat 2274.110 kb on - strand, within Rv2027cat 2274.217 kb on - strand, within Rv2027cat 2274.235 kb on + strand, within Rv2027cat 2274.236 kb on - strand, within Rv2027cat 2274.236 kb on - strand, within Rv2027cat 2274.236 kb on - strand, within Rv2027cat 2274.236 kb on - strand, within Rv2027cat 2274.236 kb on - strand, within Rv2027cat 2274.244 kb on - strand, within Rv2027cat 2274.296 kb on - strand, within Rv2027cat 2274.510 kb on + strandat 2274.511 kb on - strandat 2274.511 kb on - strandat 2274.511 kb on - strandat 2274.511 kb on - strandat 2274.511 kb on - strandat 2274.514 kb on + strandat 2274.514 kb on + strandat 2274.514 kb on + strandat 2274.514 kb on + strandat 2274.515 kb on - strandat 2274.515 kb on - strandat 2274.515 kb on - strandat 2274.515 kb on - strandat 2274.515 kb on - strandat 2274.515 kb on - strandat 2274.515 kb on - strandat 2274.693 kb on - strand, within Rv2028cat 2274.718 kb on - strand, within Rv2028cat 2275.037 kb on - strand, within Rv2028cat 2275.370 kb on - strandat 2275.445 kb on + strandat 2275.446 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction D-Lactate 10 mM (C)
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2,271,864 + -0.3
2,271,864 + -0.3
2,271,864 + +0.6
2,271,865 - +0.8
2,271,865 - -1.0
2,271,865 - -0.8
2,272,060 - Rv2026c 0.22 +0.0
2,272,298 - Rv2026c 0.49 +1.0
2,273,241 + Rv2027c 0.26 +0.2
2,273,241 + Rv2027c 0.26 +0.1
2,273,242 - Rv2027c 0.26 +0.5
2,273,242 - Rv2027c 0.26 +1.1
2,273,449 + Rv2027c 0.38 -0.9
2,273,450 - Rv2027c 0.39 -0.3
2,273,608 + Rv2027c 0.48 -2.4
2,273,609 - Rv2027c 0.48 +0.3
2,273,697 - Rv2027c 0.53 -0.3
2,273,697 - Rv2027c 0.53 -0.1
2,273,697 - Rv2027c 0.53 -0.6
2,274,003 + Rv2027c 0.71 +0.0
2,274,003 + Rv2027c 0.71 +0.1
2,274,110 - Rv2027c 0.77 +0.5
2,274,217 - Rv2027c 0.83 -0.3
2,274,235 + Rv2027c 0.84 +0.2
2,274,236 - Rv2027c 0.84 +0.6
2,274,236 - Rv2027c 0.84 +0.6
2,274,236 - Rv2027c 0.84 +0.1
2,274,236 - Rv2027c 0.84 +0.0
2,274,236 - Rv2027c 0.84 -0.8
2,274,244 - Rv2027c 0.85 -0.3
2,274,296 - Rv2027c 0.88 +0.5
2,274,510 + +0.2
2,274,511 - -0.0
2,274,511 - -0.2
2,274,511 - -1.4
2,274,511 - +0.1
2,274,511 - -0.3
2,274,514 + -0.1
2,274,514 + +0.4
2,274,514 + +0.8
2,274,514 + -0.2
2,274,515 - -0.5
2,274,515 - -0.2
2,274,515 - -0.1
2,274,515 - +0.4
2,274,515 - +0.3
2,274,515 - -0.6
2,274,515 - +1.0
2,274,693 - Rv2028c 0.15 +1.4
2,274,718 - Rv2028c 0.18 -1.0
2,275,037 - Rv2028c 0.56 +1.3
2,275,370 - +0.2
2,275,445 + +0.4
2,275,446 - -0.7

Or see this region's nucleotide sequence