Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0748

Experiment: D-Lactate 10 mM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0747 and Rv0748 are separated by 90 nucleotidesRv0748 and Rv0749 are separated by 23 nucleotidesRv0749 and Rv0749A are separated by 80 nucleotidesRv0749A and Rv0750 are separated by 158 nucleotides Rv0747: Rv0747 - PE-PGRS family protein PE_PGRS10, at 838,451 to 840,856 Rv0747 Rv0748: Rv0748 - Possible antitoxin VapB31, at 840,947 to 841,204 Rv0748 Rv0749: Rv0749 - Possible toxin VapC31. Contains PIN domain., at 841,228 to 841,656 Rv0749 Rv0749A: Rv0749A - Hypothetical protein (fragment), at 841,737 to 841,874 Rv0749A Rv0750: Rv0750 - Conserved hypothetical protein, at 842,033 to 842,278 Rv0750 Position (kb) 840 841 842Strain fitness (log2 ratio) -2 -1 0 1at 840.283 kb on + strand, within Rv0747at 840.854 kb on + strandat 840.979 kb on - strand, within Rv0748at 840.979 kb on - strand, within Rv0748at 841.150 kb on + strand, within Rv0748at 841.202 kb on + strandat 841.202 kb on + strandat 841.212 kb on + strandat 841.213 kb on - strandat 841.544 kb on + strand, within Rv0749at 841.568 kb on + strand, within Rv0749at 841.568 kb on + strand, within Rv0749at 841.672 kb on + strandat 841.738 kb on + strandat 841.739 kb on - strandat 841.996 kb on - strandat 842.021 kb on + strandat 842.021 kb on + strandat 842.021 kb on + strandat 842.021 kb on + strandat 842.022 kb on - strandat 842.022 kb on - strandat 842.043 kb on + strandat 842.044 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction D-Lactate 10 mM (C)
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840,283 + Rv0747 0.76 -2.0
840,854 + -0.4
840,979 - Rv0748 0.12 -1.5
840,979 - Rv0748 0.12 +0.7
841,150 + Rv0748 0.79 -0.7
841,202 + -0.1
841,202 + -0.3
841,212 + -0.4
841,213 - -1.4
841,544 + Rv0749 0.74 -0.2
841,568 + Rv0749 0.79 +1.0
841,568 + Rv0749 0.79 -0.1
841,672 + -0.5
841,738 + +0.0
841,739 - +0.2
841,996 - -0.3
842,021 + -0.3
842,021 + +0.1
842,021 + +0.2
842,021 + -0.7
842,022 - -0.2
842,022 - +1.7
842,043 + -0.4
842,044 - -0.8

Or see this region's nucleotide sequence