Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0904c

Experiment: 7H9 with Hygromycin B 0.0095 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0902c and Rv0903c are separated by 10 nucleotidesRv0903c and Rv0904c are separated by 130 nucleotidesRv0904c and Rv0905 are separated by 26 nucleotidesRv0905 and Rv0906 are separated by 5 nucleotides Rv0902c: Rv0902c - Two component sensor histidine kinase PrrB, at 1,004,501 to 1,005,841 Rv0902c Rv0903c: Rv0903c - Two component response transcriptional regulatory protein PrrA, at 1,005,852 to 1,006,562 Rv0903c Rv0904c: Rv0904c - Putative acetyl-coenzyme A carboxylase carboxyl transferase (subunit beta) AccD3 (accase beta chain), at 1,006,693 to 1,008,180 Rv0904c Rv0905: Rv0905 - Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 1,008,207 to 1,008,938 Rv0905 Rv0906: Rv0906 - Conserved protein, at 1,008,944 to 1,010,062 Rv0906 Position (kb) 1006 1007 1008 1009Strain fitness (log2 ratio) -2 -1 0 1 2 3at 1005.812 kb on - strandat 1006.574 kb on - strandat 1006.759 kb on + strandat 1006.768 kb on + strandat 1006.808 kb on - strandat 1006.883 kb on - strand, within Rv0904cat 1007.237 kb on - strand, within Rv0904cat 1007.272 kb on + strand, within Rv0904cat 1007.402 kb on - strand, within Rv0904cat 1007.552 kb on - strand, within Rv0904cat 1007.639 kb on + strand, within Rv0904cat 1007.652 kb on - strand, within Rv0904cat 1007.759 kb on + strand, within Rv0904cat 1007.759 kb on + strand, within Rv0904cat 1007.769 kb on - strand, within Rv0904cat 1007.769 kb on - strand, within Rv0904cat 1008.004 kb on + strand, within Rv0904cat 1008.077 kb on + strandat 1008.111 kb on + strandat 1008.140 kb on - strandat 1008.140 kb on - strandat 1008.194 kb on - strandat 1008.194 kb on - strandat 1008.194 kb on - strandat 1008.195 kb on + strandat 1008.196 kb on - strandat 1008.196 kb on - strandat 1008.277 kb on + strandat 1008.302 kb on + strand, within Rv0905at 1008.303 kb on - strand, within Rv0905at 1008.418 kb on - strand, within Rv0905at 1009.173 kb on + strand, within Rv0906

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Hygromycin B 0.0095 mM
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1,005,812 - -0.7
1,006,574 - +0.1
1,006,759 + -1.8
1,006,768 + -0.1
1,006,808 - +3.7
1,006,883 - Rv0904c 0.13 +2.0
1,007,237 - Rv0904c 0.37 -0.4
1,007,272 + Rv0904c 0.39 +0.5
1,007,402 - Rv0904c 0.48 -0.1
1,007,552 - Rv0904c 0.58 -0.1
1,007,639 + Rv0904c 0.64 +0.1
1,007,652 - Rv0904c 0.64 +0.2
1,007,759 + Rv0904c 0.72 -0.6
1,007,759 + Rv0904c 0.72 +0.1
1,007,769 - Rv0904c 0.72 +0.2
1,007,769 - Rv0904c 0.72 +0.2
1,008,004 + Rv0904c 0.88 +0.5
1,008,077 + +0.1
1,008,111 + -0.2
1,008,140 - +0.9
1,008,140 - +0.2
1,008,194 - +1.7
1,008,194 - -0.2
1,008,194 - +0.3
1,008,195 + -0.4
1,008,196 - -0.1
1,008,196 - -0.1
1,008,277 + -0.5
1,008,302 + Rv0905 0.13 -0.7
1,008,303 - Rv0905 0.13 +1.4
1,008,418 - Rv0905 0.29 -0.3
1,009,173 + Rv0906 0.20 -0.2

Or see this region's nucleotide sequence