Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2435c

Experiment: 7H9 with Hygromycin B 0.0095 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2434c and Rv2435c overlap by 4 nucleotidesRv2435c and Rv2436 are separated by 480 nucleotides Rv2434c: Rv2434c - Probable conserved transmembrane protein, at 2,729,115 to 2,730,560 Rv2434c Rv2435c: Rv2435c - Probable cyclase (adenylyl-or guanylyl-)(adenylate-or guanylate-), at 2,730,557 to 2,732,749 Rv2435c Rv2436: Rv2436 - Ribokinase RbsK, at 2,733,230 to 2,734,144 Rv2436 Position (kb) 2730 2731 2732 2733Strain fitness (log2 ratio) -1 0 1 2 3at 2729.657 kb on - strand, within Rv2434cat 2729.821 kb on - strand, within Rv2434cat 2730.465 kb on + strandat 2730.580 kb on - strandat 2730.673 kb on - strandat 2730.741 kb on + strandat 2730.887 kb on - strand, within Rv2435cat 2730.927 kb on + strand, within Rv2435cat 2731.518 kb on + strand, within Rv2435cat 2731.823 kb on - strand, within Rv2435cat 2732.235 kb on + strand, within Rv2435cat 2732.236 kb on - strand, within Rv2435cat 2732.251 kb on - strand, within Rv2435cat 2732.343 kb on + strand, within Rv2435cat 2732.571 kb on + strandat 2732.605 kb on + strandat 2732.683 kb on + strandat 2732.811 kb on + strandat 2732.931 kb on + strandat 2732.974 kb on + strandat 2732.974 kb on + strandat 2732.975 kb on - strandat 2732.975 kb on - strandat 2733.251 kb on - strandat 2733.251 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Hygromycin B 0.0095 mM
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2,729,657 - Rv2434c 0.37 +0.0
2,729,821 - Rv2434c 0.49 -0.2
2,730,465 + -0.2
2,730,580 - -1.1
2,730,673 - -0.9
2,730,741 + +0.2
2,730,887 - Rv2435c 0.15 +0.1
2,730,927 + Rv2435c 0.17 +0.1
2,731,518 + Rv2435c 0.44 +0.2
2,731,823 - Rv2435c 0.58 -0.1
2,732,235 + Rv2435c 0.77 +0.4
2,732,236 - Rv2435c 0.77 -0.2
2,732,251 - Rv2435c 0.77 +1.0
2,732,343 + Rv2435c 0.81 +3.4
2,732,571 + -0.2
2,732,605 + -0.2
2,732,683 + -0.9
2,732,811 + -1.0
2,732,931 + +0.1
2,732,974 + +0.1
2,732,974 + +0.7
2,732,975 - -1.3
2,732,975 - +0.2
2,733,251 - -0.3
2,733,251 - -0.3

Or see this region's nucleotide sequence