Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3435c

Experiment: 7H9 with Sulfaquinoxaline 0.097 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3433c and Rv3434c are separated by 1 nucleotidesRv3434c and Rv3435c are separated by 10 nucleotidesRv3435c and Rv3436c are separated by 221 nucleotides Rv3433c: Rv3433c - Conserved protein, at 3,851,792 to 3,853,213 Rv3433c Rv3434c: Rv3434c - Possible conserved transmembrane protein, at 3,853,215 to 3,853,928 Rv3434c Rv3435c: Rv3435c - Probable conserved transmembrane protein, at 3,853,939 to 3,854,793 Rv3435c Rv3436c: Rv3436c - Probable glucosamine--fructose-6-phosphate aminotransferase [isomerizing] GlmS (hexosephosphate aminotransferase) (D-fructose-6-phosphate amidotransferase) (GFAT) (L-glutamine-D-fructose-6-phosphate amidotransferase) (glucosamine-6-phosphate synthase), at 3,855,015 to 3,856,889 Rv3436c Position (kb) 3853 3854 3855Strain fitness (log2 ratio) -2 -1 0 1 2at 3853.200 kb on + strandat 3853.200 kb on + strandat 3853.201 kb on - strandat 3853.201 kb on - strandat 3853.454 kb on - strand, within Rv3434cat 3853.454 kb on - strand, within Rv3434cat 3853.454 kb on - strand, within Rv3434cat 3853.454 kb on - strand, within Rv3434cat 3853.454 kb on - strand, within Rv3434cat 3853.487 kb on - strand, within Rv3434cat 3853.573 kb on + strand, within Rv3434cat 3853.573 kb on + strand, within Rv3434cat 3853.573 kb on + strand, within Rv3434cat 3853.574 kb on - strand, within Rv3434cat 3853.847 kb on - strand, within Rv3434cat 3853.940 kb on + strandat 3853.941 kb on - strandat 3853.941 kb on - strandat 3853.941 kb on - strandat 3853.991 kb on + strandat 3853.991 kb on + strandat 3853.991 kb on + strandat 3853.991 kb on + strandat 3853.992 kb on - strandat 3853.992 kb on - strandat 3853.992 kb on - strandat 3853.992 kb on - strandat 3854.032 kb on + strand, within Rv3435cat 3854.120 kb on + strand, within Rv3435cat 3854.121 kb on - strand, within Rv3435cat 3854.505 kb on + strand, within Rv3435cat 3854.720 kb on + strandat 3854.741 kb on + strandat 3854.911 kb on - strandat 3854.997 kb on + strandat 3855.017 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Sulfaquinoxaline 0.097 mM
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3,853,200 + +0.8
3,853,200 + -0.4
3,853,201 - +0.1
3,853,201 - -0.2
3,853,454 - Rv3434c 0.33 -0.7
3,853,454 - Rv3434c 0.33 +0.4
3,853,454 - Rv3434c 0.33 +1.1
3,853,454 - Rv3434c 0.33 -1.5
3,853,454 - Rv3434c 0.33 -0.6
3,853,487 - Rv3434c 0.38 -0.2
3,853,573 + Rv3434c 0.50 -0.4
3,853,573 + Rv3434c 0.50 +0.0
3,853,573 + Rv3434c 0.50 -0.5
3,853,574 - Rv3434c 0.50 +0.1
3,853,847 - Rv3434c 0.89 +0.1
3,853,940 + +0.0
3,853,941 - -0.2
3,853,941 - -0.2
3,853,941 - -0.2
3,853,991 + -0.6
3,853,991 + -0.3
3,853,991 + +2.1
3,853,991 + +0.8
3,853,992 - -0.2
3,853,992 - +0.4
3,853,992 - -1.4
3,853,992 - -2.2
3,854,032 + Rv3435c 0.11 +0.1
3,854,120 + Rv3435c 0.21 +1.1
3,854,121 - Rv3435c 0.21 -0.0
3,854,505 + Rv3435c 0.66 +1.8
3,854,720 + -0.2
3,854,741 + -1.9
3,854,911 - +0.2
3,854,997 + +0.1
3,855,017 - +0.2

Or see this region's nucleotide sequence