Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2173

Experiment: 7H9 with Sulfaquinoxaline 0.097 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2172c and Rv2173 are separated by 310 nucleotidesRv2173 and Rv2174 are separated by 3 nucleotides Rv2172c: Rv2172c - Conserved protein, at 2,433,631 to 2,434,536 Rv2172c Rv2173: Rv2173 - Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase), at 2,434,847 to 2,435,905 Rv2173 Rv2174: Rv2174 - Alpha(1->6)mannosyltransferase. Possible conserved integral membrane protein., at 2,435,909 to 2,437,459 Rv2174 Position (kb) 2434 2435 2436Strain fitness (log2 ratio) -3 -2 -1 0 1at 2434.561 kb on - strandat 2434.666 kb on + strandat 2434.666 kb on + strandat 2434.666 kb on + strandat 2434.666 kb on + strandat 2434.666 kb on + strandat 2434.667 kb on - strandat 2434.667 kb on - strandat 2434.667 kb on - strandat 2434.677 kb on + strandat 2434.763 kb on - strandat 2434.763 kb on - strandat 2434.880 kb on + strandat 2434.880 kb on + strandat 2435.357 kb on + strand, within Rv2173at 2435.357 kb on + strand, within Rv2173at 2435.438 kb on + strand, within Rv2173at 2435.535 kb on + strand, within Rv2173at 2435.694 kb on + strand, within Rv2173at 2435.694 kb on + strand, within Rv2173

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Sulfaquinoxaline 0.097 mM
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2,434,561 - +0.3
2,434,666 + +0.4
2,434,666 + -1.5
2,434,666 + -0.3
2,434,666 + -1.4
2,434,666 + +1.6
2,434,667 - -0.2
2,434,667 - -1.2
2,434,667 - -1.1
2,434,677 + +1.4
2,434,763 - -0.7
2,434,763 - +0.1
2,434,880 + -0.3
2,434,880 + -0.7
2,435,357 + Rv2173 0.48 -0.4
2,435,357 + Rv2173 0.48 -3.5
2,435,438 + Rv2173 0.56 -1.2
2,435,535 + Rv2173 0.65 -2.4
2,435,694 + Rv2173 0.80 -0.7
2,435,694 + Rv2173 0.80 +0.0

Or see this region's nucleotide sequence