Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2033c

Experiment: 7H9 with Sulfaquinoxaline 0.097 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2032 and Rv2033c are separated by 115 nucleotidesRv2033c and Rv2034 are separated by 211 nucleotidesRv2034 and Rv2035 overlap by 4 nucleotides Rv2032: Rv2032 - Conserved protein Acg, at 2,279,129 to 2,280,124 Rv2032 Rv2033c: Rv2033c - Conserved hypothetical protein, at 2,280,240 to 2,281,082 Rv2033c Rv2034: Rv2034 - ArsR repressor protein, at 2,281,294 to 2,281,617 Rv2034 Rv2035: Rv2035 - Conserved hypothetical protein, at 2,281,614 to 2,282,102 Rv2035 Position (kb) 2280 2281 2282Strain fitness (log2 ratio) -1 0 1at 2279.663 kb on + strand, within Rv2032at 2279.827 kb on + strand, within Rv2032at 2279.850 kb on - strand, within Rv2032at 2280.148 kb on - strandat 2280.241 kb on + strandat 2280.242 kb on - strandat 2280.328 kb on - strand, within Rv2033cat 2280.328 kb on - strand, within Rv2033cat 2280.493 kb on + strand, within Rv2033cat 2280.493 kb on + strand, within Rv2033cat 2280.748 kb on + strand, within Rv2033cat 2280.877 kb on - strand, within Rv2033cat 2280.880 kb on + strand, within Rv2033cat 2281.090 kb on + strandat 2281.090 kb on + strandat 2281.090 kb on + strandat 2281.091 kb on - strandat 2281.155 kb on - strandat 2281.785 kb on - strand, within Rv2035at 2281.788 kb on + strand, within Rv2035at 2281.839 kb on + strand, within Rv2035at 2281.840 kb on - strand, within Rv2035at 2281.861 kb on + strand, within Rv2035at 2282.055 kb on + strandat 2282.056 kb on - strandat 2282.059 kb on + strandat 2282.068 kb on - strandat 2282.070 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Sulfaquinoxaline 0.097 mM
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2,279,663 + Rv2032 0.54 -0.2
2,279,827 + Rv2032 0.70 +0.2
2,279,850 - Rv2032 0.72 -0.0
2,280,148 - +0.5
2,280,241 + +0.4
2,280,242 - +0.2
2,280,328 - Rv2033c 0.10 +0.5
2,280,328 - Rv2033c 0.10 -0.4
2,280,493 + Rv2033c 0.30 +1.0
2,280,493 + Rv2033c 0.30 +0.0
2,280,748 + Rv2033c 0.60 +0.9
2,280,877 - Rv2033c 0.76 -0.7
2,280,880 + Rv2033c 0.76 +1.3
2,281,090 + +0.0
2,281,090 + -0.4
2,281,090 + +0.5
2,281,091 - -0.3
2,281,155 - -0.4
2,281,785 - Rv2035 0.35 -0.5
2,281,788 + Rv2035 0.36 +0.3
2,281,839 + Rv2035 0.46 +0.0
2,281,840 - Rv2035 0.46 +0.4
2,281,861 + Rv2035 0.51 -0.4
2,282,055 + +0.8
2,282,056 - +0.0
2,282,059 + -1.1
2,282,068 - -1.0
2,282,070 - +0.1

Or see this region's nucleotide sequence