Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1245c

Experiment: 7H9 with Sulfaquinoxaline 0.097 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1244 and Rv1245c are separated by 80 nucleotidesRv1245c and Rv1246c are separated by 56 nucleotidesRv1246c and Rv1247c overlap by 4 nucleotidesRv1247c and Rv1248c are separated by 112 nucleotides Rv1244: Rv1244 - Probable lipoprotein LpqZ, at 1,386,857 to 1,387,717 Rv1244 Rv1245c: Rv1245c - Probable short-chain type dehydrogenase/reductase, at 1,387,798 to 1,388,628 Rv1245c Rv1246c: Rv1246c - Toxin RelE, at 1,388,685 to 1,388,978 Rv1246c Rv1247c: Rv1247c - Antitoxin RelB, at 1,388,975 to 1,389,244 Rv1247c Rv1248c: Rv1248c - Multifunctional alpha-ketoglutarate metabolic enzyme, at 1,389,357 to 1,393,052 Rv1248c Position (kb) 1387 1388 1389Strain fitness (log2 ratio) -2 -1 0 1 2 3at 1386.837 kb on - strandat 1387.007 kb on + strand, within Rv1244at 1387.008 kb on - strand, within Rv1244at 1387.170 kb on + strand, within Rv1244at 1387.170 kb on + strand, within Rv1244at 1387.170 kb on + strand, within Rv1244at 1387.170 kb on + strand, within Rv1244at 1387.170 kb on + strand, within Rv1244at 1387.171 kb on - strand, within Rv1244at 1387.172 kb on + strand, within Rv1244at 1387.850 kb on + strandat 1387.987 kb on - strand, within Rv1245cat 1388.367 kb on - strand, within Rv1245cat 1388.367 kb on - strand, within Rv1245cat 1388.417 kb on - strand, within Rv1245cat 1388.438 kb on - strand, within Rv1245cat 1388.438 kb on - strand, within Rv1245cat 1388.633 kb on + strandat 1388.633 kb on + strandat 1388.633 kb on + strandat 1388.633 kb on + strandat 1388.634 kb on - strandat 1388.686 kb on + strandat 1388.776 kb on + strand, within Rv1246cat 1388.776 kb on + strand, within Rv1246cat 1388.789 kb on - strand, within Rv1246cat 1388.849 kb on + strand, within Rv1246cat 1388.850 kb on - strand, within Rv1246cat 1388.850 kb on - strand, within Rv1246cat 1388.861 kb on + strand, within Rv1246cat 1388.862 kb on - strand, within Rv1246cat 1388.862 kb on - strand, within Rv1246cat 1388.988 kb on + strandat 1389.131 kb on + strand, within Rv1247cat 1389.131 kb on + strand, within Rv1247cat 1389.261 kb on - strandat 1389.281 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Sulfaquinoxaline 0.097 mM
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1,386,837 - +0.2
1,387,007 + Rv1244 0.17 -0.5
1,387,008 - Rv1244 0.18 -0.2
1,387,170 + Rv1244 0.36 +0.3
1,387,170 + Rv1244 0.36 -0.6
1,387,170 + Rv1244 0.36 -0.2
1,387,170 + Rv1244 0.36 -1.8
1,387,170 + Rv1244 0.36 -2.7
1,387,171 - Rv1244 0.36 +0.5
1,387,172 + Rv1244 0.37 -0.7
1,387,850 + +0.2
1,387,987 - Rv1245c 0.23 +0.4
1,388,367 - Rv1245c 0.68 +0.7
1,388,367 - Rv1245c 0.68 -0.0
1,388,417 - Rv1245c 0.74 +1.8
1,388,438 - Rv1245c 0.77 +0.1
1,388,438 - Rv1245c 0.77 +0.2
1,388,633 + -0.2
1,388,633 + +0.0
1,388,633 + -0.7
1,388,633 + -0.3
1,388,634 - +0.8
1,388,686 + +1.5
1,388,776 + Rv1246c 0.31 -0.3
1,388,776 + Rv1246c 0.31 -0.1
1,388,789 - Rv1246c 0.35 -0.0
1,388,849 + Rv1246c 0.56 -0.2
1,388,850 - Rv1246c 0.56 +0.0
1,388,850 - Rv1246c 0.56 -0.2
1,388,861 + Rv1246c 0.60 +2.8
1,388,862 - Rv1246c 0.60 +0.0
1,388,862 - Rv1246c 0.60 -1.6
1,388,988 + +0.6
1,389,131 + Rv1247c 0.58 -0.2
1,389,131 + Rv1247c 0.58 +0.8
1,389,261 - +0.2
1,389,281 + +0.2

Or see this region's nucleotide sequence