Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2051c

Experiment: 7H9 with Sulfamethizole 0.026 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2049c and Rv2050 are separated by 303 nucleotidesRv2050 and Rv2051c overlap by 26 nucleotidesRv2051c and Rv2052c are separated by 157 nucleotides Rv2049c: Rv2049c - Conserved hypothetical protein, at 2,307,293 to 2,307,517 Rv2049c Rv2050: Rv2050 - Conserved protein, at 2,307,821 to 2,308,156 Rv2050 Rv2051c: Rv2051c - Polyprenol-monophosphomannose synthase Ppm1, at 2,308,131 to 2,310,755 Rv2051c Rv2052c: Rv2052c - Conserved protein, at 2,310,913 to 2,312,517 Rv2052c Position (kb) 2308 2309 2310 2311Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 2307.153 kb on - strandat 2307.254 kb on - strandat 2307.294 kb on + strandat 2307.429 kb on + strand, within Rv2049cat 2307.531 kb on + strandat 2307.561 kb on + strandat 2307.656 kb on + strandat 2307.656 kb on + strandat 2307.656 kb on + strandat 2307.657 kb on - strandat 2307.657 kb on - strandat 2307.723 kb on + strandat 2307.776 kb on + strandat 2309.378 kb on - strand, within Rv2051cat 2309.378 kb on - strand, within Rv2051cat 2309.378 kb on - strand, within Rv2051cat 2309.535 kb on - strand, within Rv2051cat 2309.653 kb on + strand, within Rv2051cat 2309.654 kb on - strand, within Rv2051cat 2310.114 kb on + strand, within Rv2051cat 2310.115 kb on - strand, within Rv2051cat 2310.115 kb on - strand, within Rv2051cat 2310.115 kb on - strand, within Rv2051cat 2310.402 kb on + strand, within Rv2051cat 2310.402 kb on + strand, within Rv2051cat 2310.514 kb on + strandat 2310.650 kb on - strandat 2310.650 kb on - strandat 2310.920 kb on + strandat 2310.921 kb on - strandat 2310.921 kb on - strandat 2310.921 kb on - strandat 2310.921 kb on - strandat 2311.017 kb on + strandat 2311.076 kb on - strand, within Rv2052cat 2311.082 kb on + strand, within Rv2052cat 2311.297 kb on + strand, within Rv2052cat 2311.297 kb on + strand, within Rv2052cat 2311.297 kb on + strand, within Rv2052cat 2311.298 kb on - strand, within Rv2052cat 2311.298 kb on - strand, within Rv2052cat 2311.352 kb on + strand, within Rv2052cat 2311.353 kb on - strand, within Rv2052cat 2311.353 kb on - strand, within Rv2052cat 2311.353 kb on - strand, within Rv2052cat 2311.353 kb on - strand, within Rv2052cat 2311.353 kb on - strand, within Rv2052cat 2311.353 kb on - strand, within Rv2052cat 2311.604 kb on - strand, within Rv2052cat 2311.624 kb on + strand, within Rv2052cat 2311.667 kb on + strand, within Rv2052c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Sulfamethizole 0.026 mM
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2,307,153 - -0.3
2,307,254 - -0.3
2,307,294 + +0.2
2,307,429 + Rv2049c 0.60 -0.2
2,307,531 + -0.9
2,307,561 + -1.0
2,307,656 + -0.5
2,307,656 + +0.3
2,307,656 + -2.9
2,307,657 - +0.8
2,307,657 - +0.0
2,307,723 + -0.0
2,307,776 + +0.8
2,309,378 - Rv2051c 0.48 +0.4
2,309,378 - Rv2051c 0.48 +1.0
2,309,378 - Rv2051c 0.48 +1.2
2,309,535 - Rv2051c 0.53 +0.3
2,309,653 + Rv2051c 0.58 -0.2
2,309,654 - Rv2051c 0.58 -0.2
2,310,114 + Rv2051c 0.76 +1.7
2,310,115 - Rv2051c 0.76 +0.4
2,310,115 - Rv2051c 0.76 +0.3
2,310,115 - Rv2051c 0.76 +0.6
2,310,402 + Rv2051c 0.87 -0.3
2,310,402 + Rv2051c 0.87 +2.1
2,310,514 + -1.5
2,310,650 - +0.6
2,310,650 - +0.8
2,310,920 + -0.0
2,310,921 - -0.4
2,310,921 - +1.8
2,310,921 - -0.2
2,310,921 - -1.7
2,311,017 + +0.9
2,311,076 - Rv2052c 0.10 -0.5
2,311,082 + Rv2052c 0.11 +0.3
2,311,297 + Rv2052c 0.24 +0.1
2,311,297 + Rv2052c 0.24 -0.1
2,311,297 + Rv2052c 0.24 +0.7
2,311,298 - Rv2052c 0.24 +1.0
2,311,298 - Rv2052c 0.24 +1.1
2,311,352 + Rv2052c 0.27 -0.1
2,311,353 - Rv2052c 0.27 +0.3
2,311,353 - Rv2052c 0.27 -0.3
2,311,353 - Rv2052c 0.27 -0.2
2,311,353 - Rv2052c 0.27 +0.6
2,311,353 - Rv2052c 0.27 +0.2
2,311,353 - Rv2052c 0.27 -0.5
2,311,604 - Rv2052c 0.43 +0.2
2,311,624 + Rv2052c 0.44 -0.1
2,311,667 + Rv2052c 0.47 +0.3

Or see this region's nucleotide sequence