Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3629c

Experiment: 7H9 with Pretomanid 0.213 ug/mL

Add experiment(s):

Zoom: Pan:

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

download SVG
500 ntRv3627c and Rv3628 are separated by 137 nucleotidesRv3628 and Rv3629c are separated by 45 nucleotidesRv3629c and Rv3630 are separated by 120 nucleotides Rv3627c: Rv3627c - Conserved protein, at 4,065,900 to 4,067,285 Rv3627c Rv3628: Rv3628 - Inorganic pyrophosphatase Ppa (pyrophosphate phospho-hydrolase) (PPASE) (inorganic diphosphatase) (diphosphate phospho-hydrolase), at 4,067,423 to 4,067,911 Rv3628 Rv3629c: Rv3629c - Probable conserved integral membrane protein, at 4,067,957 to 4,069,054 Rv3629c Rv3630: Rv3630 - Probable conserved integral membrane protein, at 4,069,175 to 4,070,470 Rv3630 Position (kb) 4067 4068 4069 4070Strain fitness (log2 ratio) -1 0 1 2 3at 4067.902 kb on + strandat 4067.920 kb on + strandat 4067.991 kb on - strandat 4068.032 kb on - strandat 4068.105 kb on - strand, within Rv3629cat 4068.147 kb on + strand, within Rv3629cat 4068.153 kb on + strand, within Rv3629cat 4068.154 kb on - strand, within Rv3629cat 4068.183 kb on + strand, within Rv3629cat 4068.183 kb on + strand, within Rv3629cat 4068.183 kb on + strand, within Rv3629cat 4068.183 kb on + strand, within Rv3629cat 4068.184 kb on - strand, within Rv3629cat 4068.184 kb on - strand, within Rv3629cat 4068.253 kb on + strand, within Rv3629cat 4068.253 kb on + strand, within Rv3629cat 4068.254 kb on - strand, within Rv3629cat 4068.254 kb on - strand, within Rv3629cat 4068.315 kb on + strand, within Rv3629cat 4068.429 kb on + strand, within Rv3629cat 4068.429 kb on + strand, within Rv3629cat 4068.429 kb on + strand, within Rv3629cat 4068.430 kb on - strand, within Rv3629cat 4068.430 kb on - strand, within Rv3629cat 4068.430 kb on - strand, within Rv3629cat 4068.530 kb on + strand, within Rv3629cat 4068.530 kb on + strand, within Rv3629cat 4068.696 kb on + strand, within Rv3629cat 4068.696 kb on + strand, within Rv3629cat 4068.696 kb on + strand, within Rv3629cat 4068.697 kb on - strand, within Rv3629cat 4068.838 kb on + strand, within Rv3629cat 4068.838 kb on + strand, within Rv3629cat 4068.839 kb on - strand, within Rv3629cat 4068.839 kb on - strand, within Rv3629cat 4068.933 kb on - strand, within Rv3629cat 4068.933 kb on - strand, within Rv3629cat 4068.991 kb on - strandat 4068.991 kb on - strandat 4069.083 kb on - strandat 4069.147 kb on + strandat 4069.147 kb on + strandat 4069.256 kb on - strandat 4069.328 kb on + strand, within Rv3630at 4069.460 kb on + strand, within Rv3630at 4069.461 kb on - strand, within Rv3630at 4069.962 kb on + strand, within Rv3630

download strain data

Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Pretomanid 0.213 ug/mL
remove
4,067,902 + +2.3
4,067,920 + -0.1
4,067,991 - +3.7
4,068,032 - +0.3
4,068,105 - Rv3629c 0.13 +0.0
4,068,147 + Rv3629c 0.17 +0.1
4,068,153 + Rv3629c 0.18 +0.1
4,068,154 - Rv3629c 0.18 +0.1
4,068,183 + Rv3629c 0.21 -1.0
4,068,183 + Rv3629c 0.21 -1.0
4,068,183 + Rv3629c 0.21 +0.1
4,068,183 + Rv3629c 0.21 -0.0
4,068,184 - Rv3629c 0.21 -0.0
4,068,184 - Rv3629c 0.21 +0.9
4,068,253 + Rv3629c 0.27 -1.3
4,068,253 + Rv3629c 0.27 +1.5
4,068,254 - Rv3629c 0.27 +1.1
4,068,254 - Rv3629c 0.27 +0.5
4,068,315 + Rv3629c 0.33 -0.1
4,068,429 + Rv3629c 0.43 -0.4
4,068,429 + Rv3629c 0.43 -0.5
4,068,429 + Rv3629c 0.43 -0.5
4,068,430 - Rv3629c 0.43 +1.9
4,068,430 - Rv3629c 0.43 -0.4
4,068,430 - Rv3629c 0.43 -0.8
4,068,530 + Rv3629c 0.52 +0.4
4,068,530 + Rv3629c 0.52 +0.4
4,068,696 + Rv3629c 0.67 +1.1
4,068,696 + Rv3629c 0.67 -1.4
4,068,696 + Rv3629c 0.67 +0.3
4,068,697 - Rv3629c 0.67 -0.4
4,068,838 + Rv3629c 0.80 -1.6
4,068,838 + Rv3629c 0.80 -0.5
4,068,839 - Rv3629c 0.80 +0.0
4,068,839 - Rv3629c 0.80 +0.5
4,068,933 - Rv3629c 0.89 +0.8
4,068,933 - Rv3629c 0.89 +0.8
4,068,991 - +0.2
4,068,991 - -1.0
4,069,083 - +1.4
4,069,147 + -0.2
4,069,147 + -0.5
4,069,256 - -0.1
4,069,328 + Rv3630 0.12 -0.1
4,069,460 + Rv3630 0.22 +0.6
4,069,461 - Rv3630 0.22 +0.6
4,069,962 + Rv3630 0.61 +0.4

Or see this region's nucleotide sequence