Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3484

Experiment: 7H9 with Pretomanid 0.213 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Pretomanid 0.213 ug/mL
3,902,118	+				+0.4
3,902,274	+		Rv3483c	0.19	-2.0
3,902,275	-		Rv3483c	0.19	+0.5
3,902,275	-		Rv3483c	0.19	-0.1
3,902,455	-		Rv3483c	0.46	-0.4
3,902,455	-		Rv3483c	0.46	-0.7
3,902,473	+		Rv3483c	0.49	-0.3
3,902,474	-		Rv3483c	0.49	-1.3
3,902,476	+		Rv3483c	0.49	-0.0
3,902,476	+		Rv3483c	0.49	-0.0
3,902,477	-		Rv3483c	0.49	+2.1
3,902,477	-		Rv3483c	0.49	-0.3
3,902,658	+		Rv3483c	0.77	+0.2
3,902,658	+		Rv3483c	0.77	-0.0
3,902,658	+		Rv3483c	0.77	+0.0
3,902,659	-		Rv3483c	0.77	-0.2
3,902,749	+				+1.2
3,902,773	-				-0.9
3,902,856	+				+0.6
3,902,856	+				+0.3
3,902,857	-				+0.5
3,902,966	+				-0.4
3,902,967	-				-0.2
3,902,967	-				+0.4
3,902,994	+				+0.0
3,902,995	-				-0.7
3,902,995	-				+0.3
3,902,997	+				-0.3
3,902,998	-				+0.1
3,903,074	+				+0.8
3,903,074	+				+0.3
3,903,074	+				-0.3
3,903,074	+				-0.6
3,903,074	+				-0.5
3,903,075	-				-1.3
3,903,075	-				-0.2
3,903,075	-				+0.2
3,903,161	+				+0.1
3,903,161	+				+0.3
3,903,162	-				+0.2
3,903,162	-				+0.2
3,903,256	+		Rv3484	0.12	+0.1
3,903,370	+		Rv3484	0.19	+0.6
3,903,371	-		Rv3484	0.19	+0.9
3,903,399	+		Rv3484	0.21	-0.0
3,903,400	-		Rv3484	0.21	+0.3
3,903,418	+		Rv3484	0.22	+0.3
3,903,419	-		Rv3484	0.22	-0.0
3,903,505	-		Rv3484	0.28	-0.4
3,903,549	+		Rv3484	0.31	+0.3
3,903,550	-		Rv3484	0.31	-0.2
3,903,676	-		Rv3484	0.39	-0.5
3,903,759	+		Rv3484	0.44	-0.1
3,903,759	+		Rv3484	0.44	+1.3
3,903,768	+		Rv3484	0.45	+0.7
3,903,769	-		Rv3484	0.45	+0.9
3,903,850	+		Rv3484	0.50	+1.9
3,903,850	+		Rv3484	0.50	+0.0
3,904,081	-		Rv3484	0.65	-0.0
3,904,142	-		Rv3484	0.69	+0.1
3,904,142	-		Rv3484	0.69	+0.8
3,904,460	+		Rv3484	0.90	-0.1
3,904,461	-		Rv3484	0.90	+0.5
3,904,527	+				-0.0
3,904,528	-				+0.6
3,904,528	-				+0.4
3,904,528	-				+0.1
3,904,528	-				-0.4
3,904,536	+				+0.4
3,904,614	+				-0.9
3,904,614	+				+0.1
3,904,615	-				+0.1
3,904,615	-				-1.0
3,904,618	+				+0.3
3,904,618	+				+1.0
3,904,618	+				-0.4
3,904,618	+				+0.1
3,904,618	+				-0.1
3,904,619	-				-0.4
3,904,619	-				+0.4
3,904,619	-				-0.3
3,904,619	-				+0.2
3,904,619	-				-0.6
3,904,619	-				+1.0
3,904,619	-				-0.4
3,904,619	-				+0.2
3,904,623	+				-0.0
3,904,772	+		Rv3485c	0.16	+0.3
3,904,773	-		Rv3485c	0.16	-0.3
3,904,808	+		Rv3485c	0.20	+0.4
3,904,877	-		Rv3485c	0.27	+1.9
3,904,981	-		Rv3485c	0.38	+0.3
3,905,085	+		Rv3485c	0.49	-0.1
3,905,085	+		Rv3485c	0.49	-1.9
3,905,085	+		Rv3485c	0.49	+0.6
3,905,085	+		Rv3485c	0.49	+0.6
3,905,086	-		Rv3485c	0.49	-0.6
3,905,086	-		Rv3485c	0.49	-1.3
3,905,272	-		Rv3485c	0.69	-0.6
3,905,272	-		Rv3485c	0.69	-0.2
3,905,272	-		Rv3485c	0.69	+0.4
3,905,272	-		Rv3485c	0.69	+0.5
3,905,425	-		Rv3485c	0.85	+0.2