Experiment: 7H9 with Pretomanid 0.213 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0500 and Rv0500A are separated by 140 nucleotides Rv0500A and Rv0500B are separated by 127 nucleotides Rv0500B and Rv0501 are separated by 77 nucleotides Rv0501 and Rv0502 are separated by 6 nucleotides
Rv0500: Rv0500 - Probable pyrroline-5-carboxylate reductase ProC (P5CR) (P5C reductase), at 590,083 to 590,970
Rv0500
Rv0500A: Rv0500A - Conserved protein, at 591,111 to 591,347
Rv0500A
Rv0500B: Rv0500B - Conserved hypothetical protein, at 591,475 to 591,576
Rv0500B
Rv0501: Rv0501 - Possible UDP-glucose 4-epimerase GalE2 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase), at 591,654 to 592,784
Rv0501
Rv0502: Rv0502 - Conserved protein, at 592,791 to 593,867
Rv0502
Position (kb) 591
592
593 Strain fitness (log2 ratio) -1
0
1
2 at 591.042 kb on + strand at 591.346 kb on - strand at 591.461 kb on + strand at 591.461 kb on + strand at 591.461 kb on + strand at 591.485 kb on + strand at 591.574 kb on + strand at 591.574 kb on + strand at 591.575 kb on - strand at 591.617 kb on + strand at 591.617 kb on + strand at 591.617 kb on + strand at 591.617 kb on + strand at 591.618 kb on - strand at 591.618 kb on - strand at 591.717 kb on + strand at 591.884 kb on + strand, within Rv0501 at 591.960 kb on + strand, within Rv0501 at 592.001 kb on + strand, within Rv0501 at 592.001 kb on + strand, within Rv0501 at 592.192 kb on - strand, within Rv0501 at 592.235 kb on + strand, within Rv0501 at 592.290 kb on + strand, within Rv0501 at 592.573 kb on - strand, within Rv0501 at 592.617 kb on + strand, within Rv0501 at 592.618 kb on - strand, within Rv0501 at 593.089 kb on - strand, within Rv0502 at 593.137 kb on + strand, within Rv0502 at 593.384 kb on + strand, within Rv0502 at 593.384 kb on + strand, within Rv0502 at 593.385 kb on - strand, within Rv0502 at 593.396 kb on + strand, within Rv0502 at 593.397 kb on - strand, within Rv0502 at 593.457 kb on + strand, within Rv0502 at 593.458 kb on - strand, within Rv0502 at 593.524 kb on + strand, within Rv0502 at 593.590 kb on - strand, within Rv0502 at 593.590 kb on - strand, within Rv0502 at 593.652 kb on - strand, within Rv0502 at 593.745 kb on + strand, within Rv0502
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Pretomanid 0.213 ug/mL remove 591,042 + +0.2 591,346 - -0.4 591,461 + -0.1 591,461 + +0.0 591,461 + -0.6 591,485 + +0.8 591,574 + +0.1 591,574 + -0.4 591,575 - -0.1 591,617 + +0.2 591,617 + +0.0 591,617 + -0.3 591,617 + -0.7 591,618 - -1.0 591,618 - -0.4 591,717 + +0.4 591,884 + Rv0501 0.20 -0.3 591,960 + Rv0501 0.27 -1.1 592,001 + Rv0501 0.31 -0.1 592,001 + Rv0501 0.31 +1.1 592,192 - Rv0501 0.48 +0.5 592,235 + Rv0501 0.51 -0.2 592,290 + Rv0501 0.56 -1.6 592,573 - Rv0501 0.81 +1.1 592,617 + Rv0501 0.85 +0.9 592,618 - Rv0501 0.85 -0.3 593,089 - Rv0502 0.28 -0.1 593,137 + Rv0502 0.32 +0.1 593,384 + Rv0502 0.55 +0.6 593,384 + Rv0502 0.55 -0.4 593,385 - Rv0502 0.55 +2.0 593,396 + Rv0502 0.56 -0.3 593,397 - Rv0502 0.56 -0.3 593,457 + Rv0502 0.62 +0.8 593,458 - Rv0502 0.62 -1.5 593,524 + Rv0502 0.68 -0.3 593,590 - Rv0502 0.74 +0.3 593,590 - Rv0502 0.74 +0.3 593,652 - Rv0502 0.80 +0.6 593,745 + Rv0502 0.89 -1.2
Or see this region's nucleotide sequence