Experiment: 7H9 with Pretomanid 0.213 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0445c and Rv0446c are separated by 48 nucleotides Rv0446c and Rv0447c are separated by 8 nucleotides Rv0447c and Rv0448c overlap by 4 nucleotides Rv0448c and Rv0449c are separated by 59 nucleotides
Rv0445c: Rv0445c - Alternative RNA polymerase sigma factor SigK, at 533,833 to 534,396
Rv0445c
Rv0446c: Rv0446c - Possible conserved transmembrane protein, at 534,445 to 535,215
Rv0446c
Rv0447c: Rv0447c - Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (cyclopropane fatty acid synthase) (CFA synthase), at 535,224 to 536,507
Rv0447c
Rv0448c: Rv0448c - Conserved hypothetical protein, at 536,504 to 537,169
Rv0448c
Rv0449c: Rv0449c - Conserved hypothetical protein, at 537,229 to 538,548
Rv0449c
Position (kb) 535
536
537 Strain fitness (log2 ratio) -1
0
1 at 534.248 kb on + strand, within Rv0445c at 534.285 kb on - strand, within Rv0445c at 534.285 kb on - strand, within Rv0445c at 534.309 kb on - strand, within Rv0445c at 534.483 kb on - strand at 534.530 kb on + strand, within Rv0446c at 534.668 kb on + strand, within Rv0446c at 534.669 kb on - strand, within Rv0446c at 534.742 kb on + strand, within Rv0446c at 534.898 kb on + strand, within Rv0446c at 534.992 kb on + strand, within Rv0446c at 534.992 kb on + strand, within Rv0446c at 534.992 kb on + strand, within Rv0446c at 535.036 kb on + strand, within Rv0446c at 535.037 kb on - strand, within Rv0446c at 535.039 kb on + strand, within Rv0446c at 535.118 kb on - strand, within Rv0446c at 535.136 kb on + strand, within Rv0446c at 535.136 kb on + strand, within Rv0446c at 535.136 kb on + strand, within Rv0446c at 535.258 kb on + strand at 535.259 kb on - strand at 535.307 kb on - strand at 535.344 kb on + strand at 535.373 kb on + strand, within Rv0447c at 535.374 kb on - strand, within Rv0447c at 535.409 kb on - strand, within Rv0447c at 535.513 kb on + strand, within Rv0447c at 535.514 kb on - strand, within Rv0447c at 535.514 kb on - strand, within Rv0447c at 535.618 kb on - strand, within Rv0447c at 535.681 kb on - strand, within Rv0447c at 535.681 kb on - strand, within Rv0447c at 535.690 kb on + strand, within Rv0447c at 535.691 kb on - strand, within Rv0447c at 535.999 kb on + strand, within Rv0447c at 536.050 kb on + strand, within Rv0447c at 536.061 kb on + strand, within Rv0447c at 536.061 kb on + strand, within Rv0447c at 536.062 kb on - strand, within Rv0447c at 536.062 kb on - strand, within Rv0447c at 536.062 kb on - strand, within Rv0447c at 536.062 kb on - strand, within Rv0447c at 536.062 kb on - strand, within Rv0447c at 536.062 kb on - strand, within Rv0447c at 536.062 kb on - strand, within Rv0447c at 536.064 kb on - strand, within Rv0447c at 536.064 kb on - strand, within Rv0447c at 536.227 kb on + strand, within Rv0447c at 536.228 kb on - strand, within Rv0447c at 536.228 kb on - strand, within Rv0447c at 536.739 kb on - strand, within Rv0448c at 536.745 kb on + strand, within Rv0448c at 536.746 kb on - strand, within Rv0448c at 536.746 kb on - strand, within Rv0448c at 536.746 kb on - strand, within Rv0448c at 536.779 kb on - strand, within Rv0448c at 536.779 kb on - strand, within Rv0448c at 536.820 kb on - strand, within Rv0448c at 536.826 kb on + strand, within Rv0448c at 536.826 kb on + strand, within Rv0448c at 536.928 kb on + strand, within Rv0448c at 537.029 kb on - strand, within Rv0448c at 537.132 kb on + strand at 537.133 kb on - strand at 537.142 kb on - strand at 537.142 kb on - strand at 537.142 kb on - strand at 537.205 kb on - strand
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Pretomanid 0.213 ug/mL remove 534,248 + Rv0445c 0.74 -0.7 534,285 - Rv0445c 0.80 -0.5 534,285 - Rv0445c 0.80 +0.8 534,309 - Rv0445c 0.84 -0.3 534,483 - +0.4 534,530 + Rv0446c 0.11 -0.0 534,668 + Rv0446c 0.29 +0.3 534,669 - Rv0446c 0.29 -1.2 534,742 + Rv0446c 0.39 +0.1 534,898 + Rv0446c 0.59 -0.3 534,992 + Rv0446c 0.71 +0.3 534,992 + Rv0446c 0.71 +0.5 534,992 + Rv0446c 0.71 +0.7 535,036 + Rv0446c 0.77 +0.0 535,037 - Rv0446c 0.77 -0.0 535,039 + Rv0446c 0.77 -0.7 535,118 - Rv0446c 0.87 -0.3 535,136 + Rv0446c 0.90 +0.1 535,136 + Rv0446c 0.90 -0.1 535,136 + Rv0446c 0.90 -1.0 535,258 + -0.3 535,259 - -0.0 535,307 - +0.2 535,344 + +0.1 535,373 + Rv0447c 0.12 +0.3 535,374 - Rv0447c 0.12 -1.0 535,409 - Rv0447c 0.14 -0.2 535,513 + Rv0447c 0.23 -0.7 535,514 - Rv0447c 0.23 -0.3 535,514 - Rv0447c 0.23 -0.6 535,618 - Rv0447c 0.31 -1.3 535,681 - Rv0447c 0.36 -0.2 535,681 - Rv0447c 0.36 +0.4 535,690 + Rv0447c 0.36 +0.1 535,691 - Rv0447c 0.36 -1.0 535,999 + Rv0447c 0.60 +0.4 536,050 + Rv0447c 0.64 +0.2 536,061 + Rv0447c 0.65 -0.3 536,061 + Rv0447c 0.65 -0.3 536,062 - Rv0447c 0.65 -0.4 536,062 - Rv0447c 0.65 -0.5 536,062 - Rv0447c 0.65 -1.3 536,062 - Rv0447c 0.65 -0.0 536,062 - Rv0447c 0.65 +0.4 536,062 - Rv0447c 0.65 +1.0 536,062 - Rv0447c 0.65 -0.7 536,064 - Rv0447c 0.65 -0.5 536,064 - Rv0447c 0.65 +0.4 536,227 + Rv0447c 0.78 -0.4 536,228 - Rv0447c 0.78 +0.1 536,228 - Rv0447c 0.78 -0.2 536,739 - Rv0448c 0.35 -0.1 536,745 + Rv0448c 0.36 -0.5 536,746 - Rv0448c 0.36 +0.7 536,746 - Rv0448c 0.36 +0.2 536,746 - Rv0448c 0.36 -0.7 536,779 - Rv0448c 0.41 +0.2 536,779 - Rv0448c 0.41 +1.5 536,820 - Rv0448c 0.47 +0.0 536,826 + Rv0448c 0.48 -0.3 536,826 + Rv0448c 0.48 +0.1 536,928 + Rv0448c 0.64 -0.6 537,029 - Rv0448c 0.79 +0.6 537,132 + -0.6 537,133 - +0.3 537,142 - -0.0 537,142 - +1.6 537,142 - +0.5 537,205 - +1.0
Or see this region's nucleotide sequence