Experiment: 7H9 with Pretomanid 0.213 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0377 and Rv0378 are separated by 250 nucleotides Rv0378 and Rv0379 are separated by 118 nucleotides Rv0379 and Rv0380c are separated by 75 nucleotides
Rv0377: Rv0377 - Probable transcriptional regulatory protein (probably LysR-family), at 454,421 to 455,386
Rv0377
Rv0378: Rv0378 - Conserved hypothetical glycine rich protein, at 455,637 to 455,858
Rv0378
Rv0379: Rv0379 - Possible protein transport protein SecE2, at 455,977 to 456,192
Rv0379
Rv0380c: Rv0380c - Possible RNA methyltransferase (RNA methylase), at 456,268 to 456,819
Rv0380c
Position (kb) 455
456 Strain fitness (log2 ratio) -3
-2
-1
0
1 at 454.900 kb on - strand, within Rv0377 at 455.025 kb on + strand, within Rv0377 at 455.026 kb on - strand, within Rv0377 at 455.308 kb on + strand at 455.308 kb on + strand at 455.786 kb on - strand, within Rv0378 at 455.961 kb on + strand at 455.961 kb on + strand at 455.963 kb on + strand at 455.963 kb on + strand at 455.970 kb on + strand at 455.986 kb on + strand at 455.987 kb on - strand at 455.987 kb on - strand at 455.987 kb on - strand at 456.139 kb on + strand, within Rv0379 at 456.139 kb on + strand, within Rv0379 at 456.190 kb on + strand at 456.269 kb on + strand at 456.270 kb on - strand at 456.412 kb on - strand, within Rv0380c at 456.827 kb on + strand
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Pretomanid 0.213 ug/mL remove 454,900 - Rv0377 0.50 -3.1 455,025 + Rv0377 0.63 -0.6 455,026 - Rv0377 0.63 -0.2 455,308 + +0.6 455,308 + +0.4 455,786 - Rv0378 0.67 +0.2 455,961 + +0.2 455,961 + -0.3 455,963 + +0.2 455,963 + +0.4 455,970 + +0.0 455,986 + -0.2 455,987 - +0.3 455,987 - -0.2 455,987 - -0.4 456,139 + Rv0379 0.75 -0.5 456,139 + Rv0379 0.75 +1.5 456,190 + -0.3 456,269 + -0.9 456,270 - -0.4 456,412 - Rv0380c 0.26 +0.0 456,827 + +0.1
Or see this region's nucleotide sequence