Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2821c

Experiment: 7H9 with Pretomanid 0.213 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Pretomanid 0.213 ug/mL
3,127,394	+				+0.1
3,127,414	-				+0.8
3,127,414	-				-0.3
3,127,530	+		Rv2820c	0.18	-0.6
3,127,550	+		Rv2820c	0.20	-0.2
3,127,573	-		Rv2820c	0.23	-0.6
3,127,617	-		Rv2820c	0.28	-0.2
3,128,175	+		Rv2820c	0.89	+1.0
3,128,176	-		Rv2820c	0.89	-0.2
3,128,176	-		Rv2820c	0.89	-0.7
3,128,197	+				-0.3
3,128,198	-				-0.3
3,128,254	+				-0.8
3,128,684	-		Rv2821c	0.61	-0.7
3,128,744	-		Rv2821c	0.69	-1.0
3,128,957	+				-0.1
3,128,996	-				-0.4
3,129,004	+				-0.2
3,129,004	+				-2.2
3,129,005	-				+0.3
3,129,025	+		Rv2822c	0.14	-0.6
3,129,063	+		Rv2822c	0.24	+1.8
3,129,081	+		Rv2822c	0.29	-0.6
3,129,081	+		Rv2822c	0.29	-0.2
3,129,111	-		Rv2822c	0.37	+0.3
3,129,111	-		Rv2822c	0.37	-0.4
3,129,137	-		Rv2822c	0.44	-0.5
3,129,137	-		Rv2822c	0.44	+1.5
3,129,243	+		Rv2822c	0.72	-0.1
3,129,244	-		Rv2822c	0.72	+0.3
3,129,325	+				+0.5
3,129,326	-				-0.2
3,129,378	+				+1.0
3,129,378	+				-0.9
3,129,379	-				-0.2
3,129,484	+				-0.2
3,129,504	+				-0.4
3,129,505	-				-0.6
3,129,505	-				-0.5
3,129,599	+		Rv2823c	0.10	-0.4
3,129,621	+		Rv2823c	0.11	+0.1
3,129,765	+		Rv2823c	0.17	-0.4
3,129,765	+		Rv2823c	0.17	-0.3