Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0765c

Experiment: 7H9 with Pretomanid 0.213 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0764c and Rv0765c overlap by 1 nucleotidesRv0765c and Rv0766c overlap by 1 nucleotides Rv0764c: Rv0764c - Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM), at 856,682 to 858,037 Rv0764c Rv0765c: Rv0765c - Probable oxidoreductase, at 858,037 to 858,864 Rv0765c Rv0766c: Rv0766c - Probable cytochrome P450 123 Cyp123, at 858,864 to 860,072 Rv0766c Position (kb) 858 859Strain fitness (log2 ratio) -2 -1 0 1at 857.485 kb on - strand, within Rv0764cat 857.497 kb on - strand, within Rv0764cat 857.497 kb on - strand, within Rv0764cat 857.601 kb on + strand, within Rv0764cat 857.602 kb on - strand, within Rv0764cat 858.390 kb on - strand, within Rv0765cat 858.514 kb on + strand, within Rv0765cat 858.865 kb on + strandat 859.229 kb on - strand, within Rv0766cat 859.492 kb on + strand, within Rv0766c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Pretomanid 0.213 ug/mL
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857,485 - Rv0764c 0.59 -0.7
857,497 - Rv0764c 0.60 +0.1
857,497 - Rv0764c 0.60 +1.3
857,601 + Rv0764c 0.68 -0.2
857,602 - Rv0764c 0.68 -2.1
858,390 - Rv0765c 0.43 +1.0
858,514 + Rv0765c 0.58 +0.1
858,865 + +1.1
859,229 - Rv0766c 0.30 -0.5
859,492 + Rv0766c 0.52 -0.4

Or see this region's nucleotide sequence