Experiment: 7H9 with Pretomanid 0.213 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0471c and Rv0472c are separated by 9 nucleotides Rv0472c and Rv0473 are separated by 136 nucleotides Rv0473 and Rv0474 are separated by 86 nucleotides Rv0474 and Rv0475 are separated by 353 nucleotides
Rv0471c: Rv0471c - Hypothetical protein, at 562,225 to 562,713
Rv0471c
Rv0472c: Rv0472c - Probable transcriptional regulatory protein (possibly TetR-family), at 562,723 to 563,427
Rv0472c
Rv0473: Rv0473 - Possible conserved transmembrane protein, at 563,564 to 564,934
Rv0473
Rv0474: Rv0474 - Probable transcriptional regulatory protein, at 565,021 to 565,443
Rv0474
Rv0475: Rv0475 - Iron-regulated heparin binding hemagglutinin HbhA (adhesin), at 565,797 to 566,396
Rv0475
Position (kb) 563
564
565 Strain fitness (log2 ratio) -4
-3
-2
-1
0
1
2 at 562.670 kb on + strand at 562.671 kb on - strand at 562.724 kb on + strand at 562.724 kb on + strand at 562.724 kb on + strand at 562.841 kb on + strand, within Rv0472c at 562.923 kb on - strand, within Rv0472c at 563.050 kb on - strand, within Rv0472c at 563.102 kb on + strand, within Rv0472c at 563.102 kb on + strand, within Rv0472c at 563.103 kb on - strand, within Rv0472c at 563.244 kb on - strand, within Rv0472c at 563.278 kb on + strand, within Rv0472c at 563.415 kb on + strand at 563.464 kb on + strand at 563.464 kb on + strand at 563.534 kb on + strand at 563.535 kb on - strand at 563.535 kb on - strand at 563.535 kb on - strand at 563.575 kb on + strand at 563.575 kb on + strand at 563.575 kb on + strand at 563.575 kb on + strand at 563.575 kb on + strand at 563.848 kb on + strand, within Rv0473 at 564.036 kb on + strand, within Rv0473 at 564.036 kb on + strand, within Rv0473 at 564.260 kb on - strand, within Rv0473 at 564.410 kb on - strand, within Rv0473 at 564.540 kb on + strand, within Rv0473 at 564.540 kb on + strand, within Rv0473 at 564.541 kb on - strand, within Rv0473 at 564.756 kb on - strand, within Rv0473 at 564.908 kb on + strand at 564.908 kb on + strand at 564.975 kb on + strand at 564.976 kb on - strand at 564.976 kb on - strand at 565.009 kb on + strand at 565.009 kb on + strand at 565.015 kb on + strand at 565.016 kb on - strand at 565.198 kb on - strand, within Rv0474 at 565.261 kb on + strand, within Rv0474 at 565.262 kb on - strand, within Rv0474 at 565.262 kb on - strand, within Rv0474 at 565.326 kb on + strand, within Rv0474 at 565.365 kb on + strand, within Rv0474 at 565.369 kb on + strand, within Rv0474 at 565.369 kb on + strand, within Rv0474 at 565.369 kb on + strand, within Rv0474 at 565.380 kb on + strand, within Rv0474 at 565.380 kb on + strand, within Rv0474 at 565.380 kb on + strand, within Rv0474 at 565.380 kb on + strand, within Rv0474 at 565.380 kb on + strand, within Rv0474 at 565.381 kb on - strand, within Rv0474 at 565.592 kb on + strand at 565.592 kb on + strand at 565.592 kb on + strand at 565.592 kb on + strand at 565.592 kb on + strand at 565.592 kb on + strand at 565.592 kb on + strand at 565.593 kb on - strand at 565.593 kb on - strand at 565.593 kb on - strand at 565.593 kb on - strand at 565.593 kb on - strand at 565.593 kb on - strand at 565.621 kb on + strand at 565.621 kb on + strand at 565.622 kb on - strand at 565.704 kb on - strand at 565.704 kb on - strand at 565.704 kb on - strand at 565.704 kb on - strand at 565.754 kb on + strand at 565.754 kb on + strand at 565.755 kb on - strand at 565.755 kb on - strand at 565.755 kb on - strand at 565.755 kb on - strand at 565.776 kb on + strand at 565.780 kb on + strand at 565.780 kb on + strand at 565.780 kb on + strand at 565.781 kb on - strand at 565.781 kb on - strand
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Pretomanid 0.213 ug/mL remove 562,670 + -0.5 562,671 - +0.3 562,724 + +0.2 562,724 + -0.1 562,724 + -0.3 562,841 + Rv0472c 0.17 -0.6 562,923 - Rv0472c 0.28 -1.6 563,050 - Rv0472c 0.46 +1.2 563,102 + Rv0472c 0.54 -1.1 563,102 + Rv0472c 0.54 -2.9 563,103 - Rv0472c 0.54 -3.7 563,244 - Rv0472c 0.74 +0.5 563,278 + Rv0472c 0.79 +0.0 563,415 + -3.8 563,464 + -0.8 563,464 + +1.8 563,534 + -0.1 563,535 - -0.1 563,535 - -0.2 563,535 - -0.3 563,575 + -0.2 563,575 + +0.2 563,575 + +0.8 563,575 + -0.5 563,575 + -0.2 563,848 + Rv0473 0.21 -0.1 564,036 + Rv0473 0.34 -0.3 564,036 + Rv0473 0.34 +1.4 564,260 - Rv0473 0.51 +0.6 564,410 - Rv0473 0.62 +0.4 564,540 + Rv0473 0.71 +0.8 564,540 + Rv0473 0.71 -0.9 564,541 - Rv0473 0.71 -0.2 564,756 - Rv0473 0.87 +0.6 564,908 + -1.0 564,908 + -0.1 564,975 + +0.1 564,976 - -0.1 564,976 - -1.0 565,009 + -0.9 565,009 + +0.1 565,015 + +0.5 565,016 - -0.6 565,198 - Rv0474 0.42 -0.4 565,261 + Rv0474 0.57 -1.0 565,262 - Rv0474 0.57 -0.7 565,262 - Rv0474 0.57 -0.2 565,326 + Rv0474 0.72 +0.8 565,365 + Rv0474 0.81 +1.8 565,369 + Rv0474 0.82 +0.2 565,369 + Rv0474 0.82 +0.3 565,369 + Rv0474 0.82 +0.4 565,380 + Rv0474 0.85 +0.8 565,380 + Rv0474 0.85 +1.0 565,380 + Rv0474 0.85 +0.4 565,380 + Rv0474 0.85 +0.2 565,380 + Rv0474 0.85 -0.5 565,381 - Rv0474 0.85 +0.7 565,592 + +0.8 565,592 + -0.0 565,592 + +0.9 565,592 + -0.4 565,592 + -1.9 565,592 + +0.8 565,592 + -0.4 565,593 - +0.1 565,593 - -1.2 565,593 - +0.2 565,593 - -0.1 565,593 - -0.2 565,593 - +0.2 565,621 + +0.3 565,621 + +0.4 565,622 - -0.3 565,704 - +1.8 565,704 - -0.4 565,704 - +0.2 565,704 - -0.5 565,754 + +0.9 565,754 + +0.8 565,755 - -0.2 565,755 - +0.1 565,755 - -0.6 565,755 - -0.4 565,776 + +1.1 565,780 + -0.3 565,780 + -0.7 565,780 + -0.2 565,781 - -0.1 565,781 - +0.4
Or see this region's nucleotide sequence