Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0085

Experiment: 7H9 with Pretomanid 0.213 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0083 and Rv0084 are separated by 5 nucleotidesRv0084 and Rv0085 are separated by 10 nucleotidesRv0085 and Rv0086 overlap by 1 nucleotides Rv0083: Rv0083 - Probable oxidoreductase, at 90,400 to 92,322 Rv0083 Rv0084: Rv0084 - Possible formate hydrogenlyase HycD (FHL), at 92,328 to 93,278 Rv0084 Rv0085: Rv0085 - Possible hydrogenase HycP, at 93,289 to 93,951 Rv0085 Rv0086: Rv0086 - Possible hydrogenase HycQ, at 93,951 to 95,417 Rv0086 Position (kb) 93 94Strain fitness (log2 ratio) -1 0 1at 92.973 kb on + strand, within Rv0084at 92.973 kb on + strand, within Rv0084at 93.774 kb on - strand, within Rv0085at 93.774 kb on - strand, within Rv0085at 94.245 kb on - strand, within Rv0086at 94.257 kb on - strand, within Rv0086at 94.428 kb on + strand, within Rv0086at 94.777 kb on - strand, within Rv0086

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Pretomanid 0.213 ug/mL
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92,973 + Rv0084 0.68 +0.6
92,973 + Rv0084 0.68 +1.1
93,774 - Rv0085 0.73 +0.1
93,774 - Rv0085 0.73 +1.5
94,245 - Rv0086 0.20 +0.6
94,257 - Rv0086 0.21 -0.3
94,428 + Rv0086 0.33 +0.8
94,777 - Rv0086 0.56 -0.5

Or see this region's nucleotide sequence