Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1180

Experiment: 7H9 with para-aminosalicylic 0.086 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1179c and Rv1180 are separated by 425 nucleotidesRv1180 and Rv1181 are separated by 42 nucleotides Rv1179c: Rv1179c - Unknown protein, at 1,310,480 to 1,313,299 Rv1179c Rv1180: Rv1180 - Probable polyketide beta-ketoacyl synthase Pks3, at 1,313,725 to 1,315,191 Rv1180 Rv1181: Rv1181 - Probable polyketide beta-ketoacyl synthase Pks4, at 1,315,234 to 1,319,982 Rv1181 Position (kb) 1313 1314 1315 1316Strain fitness (log2 ratio) -2 -1 0 1 2 3at 1312.792 kb on + strand, within Rv1179cat 1312.792 kb on + strand, within Rv1179cat 1312.792 kb on + strand, within Rv1179cat 1312.793 kb on - strand, within Rv1179cat 1312.793 kb on - strand, within Rv1179cat 1312.797 kb on - strand, within Rv1179cat 1312.839 kb on - strand, within Rv1179cat 1312.975 kb on - strand, within Rv1179cat 1313.247 kb on - strandat 1313.457 kb on + strandat 1313.557 kb on + strandat 1313.587 kb on - strandat 1313.627 kb on + strandat 1313.675 kb on - strandat 1313.879 kb on - strand, within Rv1180at 1314.211 kb on + strand, within Rv1180at 1314.601 kb on + strand, within Rv1180at 1314.719 kb on - strand, within Rv1180at 1315.106 kb on + strandat 1315.574 kb on + strandat 1315.575 kb on - strandat 1316.068 kb on + strand, within Rv1181

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with para-aminosalicylic 0.086 ug/mL
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1,312,792 + Rv1179c 0.82 -0.1
1,312,792 + Rv1179c 0.82 +0.7
1,312,792 + Rv1179c 0.82 +0.4
1,312,793 - Rv1179c 0.82 -0.9
1,312,793 - Rv1179c 0.82 -0.4
1,312,797 - Rv1179c 0.82 -0.3
1,312,839 - Rv1179c 0.84 -0.0
1,312,975 - Rv1179c 0.88 -0.4
1,313,247 - -1.0
1,313,457 + +0.2
1,313,557 + +2.8
1,313,587 - -1.9
1,313,627 + +0.3
1,313,675 - -0.7
1,313,879 - Rv1180 0.10 +0.2
1,314,211 + Rv1180 0.33 +1.1
1,314,601 + Rv1180 0.60 +0.1
1,314,719 - Rv1180 0.68 -0.3
1,315,106 + +0.3
1,315,574 + -0.8
1,315,575 - +0.3
1,316,068 + Rv1181 0.18 -0.7

Or see this region's nucleotide sequence