Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3470c

Experiment: 7H9 with Meropenem 9.6 ug/mL

Add experiment(s):

Zoom: Pan:

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

download SVG
500 ntRv3469c and Rv3470c are separated by 60 nucleotidesRv3470c and Rv3471c are separated by 5 nucleotidesRv3471c and Rv3472 are separated by 20 nucleotides Rv3469c: Rv3469c - Probable 4-hydroxy-2-oxovalerate aldolase MhpE (HOA), at 3,886,073 to 3,887,083 Rv3469c Rv3470c: Rv3470c - Probable acetolactate synthase (large subunit) IlvB2 (AHAS) (acetohydroxy-acid synthase large subunit) (ALS), at 3,887,144 to 3,888,802 Rv3470c Rv3471c: Rv3471c - Conserved hypothetical protein, at 3,888,808 to 3,889,341 Rv3471c Rv3472: Rv3472 - Conserved protein, at 3,889,362 to 3,889,868 Rv3472 Position (kb) 3887 3888 3889Strain fitness (log2 ratio) -1 0 1 2at 3886.292 kb on - strand, within Rv3469cat 3886.539 kb on + strand, within Rv3469cat 3886.576 kb on + strand, within Rv3469cat 3886.577 kb on - strand, within Rv3469cat 3886.751 kb on + strand, within Rv3469cat 3886.751 kb on + strand, within Rv3469cat 3886.752 kb on - strand, within Rv3469cat 3886.752 kb on - strand, within Rv3469cat 3886.870 kb on - strand, within Rv3469cat 3886.870 kb on - strand, within Rv3469cat 3887.019 kb on + strandat 3887.019 kb on + strandat 3887.483 kb on + strand, within Rv3470cat 3887.483 kb on + strand, within Rv3470cat 3887.483 kb on + strand, within Rv3470cat 3887.994 kb on + strand, within Rv3470cat 3887.995 kb on - strand, within Rv3470cat 3888.020 kb on + strand, within Rv3470cat 3888.021 kb on - strand, within Rv3470cat 3888.246 kb on - strand, within Rv3470cat 3888.523 kb on + strand, within Rv3470cat 3888.738 kb on - strandat 3888.746 kb on + strandat 3888.863 kb on - strand, within Rv3471cat 3888.866 kb on + strand, within Rv3471cat 3888.910 kb on + strand, within Rv3471cat 3888.910 kb on + strand, within Rv3471cat 3888.910 kb on + strand, within Rv3471cat 3888.911 kb on - strand, within Rv3471cat 3888.911 kb on - strand, within Rv3471cat 3889.393 kb on + strandat 3889.393 kb on + strandat 3889.528 kb on + strand, within Rv3472at 3889.528 kb on + strand, within Rv3472at 3889.536 kb on + strand, within Rv3472at 3889.593 kb on + strand, within Rv3472at 3889.662 kb on + strand, within Rv3472

download strain data

Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Meropenem 9.6 ug/mL
remove
3,886,292 - Rv3469c 0.22 +0.1
3,886,539 + Rv3469c 0.46 +0.1
3,886,576 + Rv3469c 0.50 -0.4
3,886,577 - Rv3469c 0.50 -0.4
3,886,751 + Rv3469c 0.67 -0.0
3,886,751 + Rv3469c 0.67 -0.0
3,886,752 - Rv3469c 0.67 +1.4
3,886,752 - Rv3469c 0.67 +0.0
3,886,870 - Rv3469c 0.79 -1.6
3,886,870 - Rv3469c 0.79 +0.3
3,887,019 + -0.1
3,887,019 + +0.4
3,887,483 + Rv3470c 0.20 +0.5
3,887,483 + Rv3470c 0.20 +1.8
3,887,483 + Rv3470c 0.20 +0.0
3,887,994 + Rv3470c 0.51 +0.1
3,887,995 - Rv3470c 0.51 -0.2
3,888,020 + Rv3470c 0.53 +0.1
3,888,021 - Rv3470c 0.53 +0.4
3,888,246 - Rv3470c 0.66 +1.1
3,888,523 + Rv3470c 0.83 +0.2
3,888,738 - +1.2
3,888,746 + -0.3
3,888,863 - Rv3471c 0.10 +0.5
3,888,866 + Rv3471c 0.11 -0.5
3,888,910 + Rv3471c 0.19 +0.1
3,888,910 + Rv3471c 0.19 -0.4
3,888,910 + Rv3471c 0.19 -0.1
3,888,911 - Rv3471c 0.19 +0.1
3,888,911 - Rv3471c 0.19 -0.7
3,889,393 + -0.2
3,889,393 + +0.2
3,889,528 + Rv3472 0.33 +0.0
3,889,528 + Rv3472 0.33 -0.5
3,889,536 + Rv3472 0.34 +0.2
3,889,593 + Rv3472 0.46 -0.5
3,889,662 + Rv3472 0.59 +0.5

Or see this region's nucleotide sequence