Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2483c

Experiment: 7H9 with Meropenem 9.6 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2482c and Rv2483c overlap by 4 nucleotidesRv2483c and Rv2484c overlap by 4 nucleotides Rv2482c: Rv2482c - Probable glycerol-3-phosphate acyltransferase PlsB2 (GPAT), at 2,786,914 to 2,789,283 Rv2482c Rv2483c: Rv2483c - Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoserine phosphohydrolase) (PSP) (pspase) + 1-acyl-SN-glycerol-3-phosphate acyltransferase (1-AGP acyltransferase) (1-AGPAT) (lysophosphatidic acid acyltransferase) (LPAAT), at 2,789,280 to 2,791,022 Rv2483c Rv2484c: Rv2484c - Possible triacylglycerol synthase (diacylglycerol acyltransferase), at 2,791,019 to 2,792,494 Rv2484c Position (kb) 2789 2790 2791 2792Strain fitness (log2 ratio) -1 0 1 2at 2788.284 kb on - strand, within Rv2482cat 2788.287 kb on + strand, within Rv2482cat 2788.289 kb on + strand, within Rv2482cat 2788.517 kb on + strand, within Rv2482cat 2788.727 kb on + strand, within Rv2482cat 2789.028 kb on + strand, within Rv2482cat 2789.028 kb on + strand, within Rv2482cat 2789.029 kb on - strand, within Rv2482cat 2789.513 kb on - strand, within Rv2483cat 2789.566 kb on + strand, within Rv2483cat 2789.751 kb on - strand, within Rv2483cat 2789.790 kb on - strand, within Rv2483cat 2790.352 kb on + strand, within Rv2483cat 2790.388 kb on - strand, within Rv2483cat 2790.391 kb on + strand, within Rv2483cat 2790.392 kb on - strand, within Rv2483cat 2790.824 kb on + strand, within Rv2483cat 2791.182 kb on + strand, within Rv2484cat 2791.294 kb on - strand, within Rv2484cat 2791.298 kb on - strand, within Rv2484cat 2791.298 kb on - strand, within Rv2484cat 2791.726 kb on + strand, within Rv2484cat 2791.987 kb on + strand, within Rv2484cat 2791.988 kb on - strand, within Rv2484cat 2792.013 kb on + strand, within Rv2484cat 2792.013 kb on + strand, within Rv2484c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Meropenem 9.6 ug/mL
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2,788,284 - Rv2482c 0.58 +0.3
2,788,287 + Rv2482c 0.58 +0.1
2,788,289 + Rv2482c 0.58 +0.3
2,788,517 + Rv2482c 0.68 -0.5
2,788,727 + Rv2482c 0.76 +0.0
2,789,028 + Rv2482c 0.89 +0.3
2,789,028 + Rv2482c 0.89 -0.1
2,789,029 - Rv2482c 0.89 +0.9
2,789,513 - Rv2483c 0.13 -0.3
2,789,566 + Rv2483c 0.16 -0.7
2,789,751 - Rv2483c 0.27 +1.8
2,789,790 - Rv2483c 0.29 -1.1
2,790,352 + Rv2483c 0.62 -0.2
2,790,388 - Rv2483c 0.64 +1.2
2,790,391 + Rv2483c 0.64 -0.1
2,790,392 - Rv2483c 0.64 +0.2
2,790,824 + Rv2483c 0.89 -0.3
2,791,182 + Rv2484c 0.11 -0.8
2,791,294 - Rv2484c 0.19 -0.2
2,791,298 - Rv2484c 0.19 -0.7
2,791,298 - Rv2484c 0.19 -0.3
2,791,726 + Rv2484c 0.48 -0.7
2,791,987 + Rv2484c 0.66 -0.8
2,791,988 - Rv2484c 0.66 -0.0
2,792,013 + Rv2484c 0.67 -1.4
2,792,013 + Rv2484c 0.67 -1.6

Or see this region's nucleotide sequence