Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1478

Experiment: 7H9 with Meropenem 9.6 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1477 and Rv1478 are separated by 10 nucleotidesRv1478 and Rv1479 are separated by 138 nucleotides Rv1477: Rv1477 - Peptidoglycan hydrolase, at 1,666,990 to 1,668,408 Rv1477 Rv1478: Rv1478 - Possible invasion protein, at 1,668,419 to 1,669,144 Rv1478 Rv1479: Rv1479 - Probable transcriptional regulatory protein MoxR1, at 1,669,283 to 1,670,416 Rv1479 Position (kb) 1668 1669 1670Strain fitness (log2 ratio) -3 -2 -1 0 1at 1668.382 kb on + strandat 1668.394 kb on + strandat 1668.404 kb on - strandat 1668.407 kb on - strandat 1668.758 kb on + strand, within Rv1478at 1668.758 kb on + strand, within Rv1478at 1668.759 kb on - strand, within Rv1478at 1668.798 kb on - strand, within Rv1478at 1668.890 kb on + strand, within Rv1478at 1668.941 kb on + strand, within Rv1478at 1668.941 kb on + strand, within Rv1478at 1668.942 kb on - strand, within Rv1478at 1668.942 kb on - strand, within Rv1478at 1668.942 kb on - strand, within Rv1478at 1669.031 kb on + strand, within Rv1478at 1669.032 kb on - strand, within Rv1478at 1669.032 kb on - strand, within Rv1478at 1669.032 kb on - strand, within Rv1478at 1669.203 kb on + strandat 1669.203 kb on + strandat 1669.203 kb on + strandat 1669.204 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Meropenem 9.6 ug/mL
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1,668,382 + -3.0
1,668,394 + -2.5
1,668,404 - -1.3
1,668,407 - -0.7
1,668,758 + Rv1478 0.47 -0.4
1,668,758 + Rv1478 0.47 -0.8
1,668,759 - Rv1478 0.47 +0.2
1,668,798 - Rv1478 0.52 -2.2
1,668,890 + Rv1478 0.65 -0.9
1,668,941 + Rv1478 0.72 -1.1
1,668,941 + Rv1478 0.72 -1.9
1,668,942 - Rv1478 0.72 -0.9
1,668,942 - Rv1478 0.72 -0.2
1,668,942 - Rv1478 0.72 -0.7
1,669,031 + Rv1478 0.84 -0.7
1,669,032 - Rv1478 0.84 -0.7
1,669,032 - Rv1478 0.84 -0.7
1,669,032 - Rv1478 0.84 -0.3
1,669,203 + -0.1
1,669,203 + +0.7
1,669,203 + -0.5
1,669,204 + -0.1

Or see this region's nucleotide sequence