Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0940c

Experiment: 7H9 with Meropenem 9.6 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0939 and Rv0940c are separated by 246 nucleotidesRv0940c and Rv0941c are separated by 84 nucleotidesRv0941c and Rv0942 are separated by 42 nucleotides Rv0939: Rv0939 - Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase, at 1,048,412 to 1,050,346 Rv0939 Rv0940c: Rv0940c - Possible oxidoreductase, at 1,050,593 to 1,051,459 Rv0940c Rv0941c: Rv0941c - Conserved hypothetical protein, at 1,051,544 to 1,052,317 Rv0941c Rv0942: Rv0942 - Hypothetical protein, at 1,052,360 to 1,052,638 Rv0942 Position (kb) 1050 1051 1052Strain fitness (log2 ratio) -1 0 1 2 3at 1050.248 kb on + strandat 1050.248 kb on + strandat 1051.318 kb on - strand, within Rv0940cat 1051.446 kb on + strandat 1051.498 kb on + strandat 1051.793 kb on + strand, within Rv0941cat 1051.822 kb on + strand, within Rv0941cat 1051.823 kb on - strand, within Rv0941cat 1052.057 kb on + strand, within Rv0941cat 1052.058 kb on - strand, within Rv0941cat 1052.149 kb on + strand, within Rv0941cat 1052.260 kb on + strandat 1052.260 kb on + strandat 1052.261 kb on - strandat 1052.261 kb on - strandat 1052.261 kb on - strandat 1052.261 kb on - strandat 1052.261 kb on - strandat 1052.379 kb on + strandat 1052.380 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Meropenem 9.6 ug/mL
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1,050,248 + +0.3
1,050,248 + +0.1
1,051,318 - Rv0940c 0.84 +0.3
1,051,446 + -0.3
1,051,498 + -0.2
1,051,793 + Rv0941c 0.32 -0.5
1,051,822 + Rv0941c 0.36 -0.2
1,051,823 - Rv0941c 0.36 +2.9
1,052,057 + Rv0941c 0.66 -0.2
1,052,058 - Rv0941c 0.66 -0.5
1,052,149 + Rv0941c 0.78 -0.1
1,052,260 + -0.3
1,052,260 + -1.2
1,052,261 - -0.2
1,052,261 - +0.1
1,052,261 - +0.2
1,052,261 - -0.2
1,052,261 - -0.4
1,052,379 + -0.5
1,052,380 - +0.1

Or see this region's nucleotide sequence