Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0451c

Experiment: 7H9 with Meropenem 9.6 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0450c and Rv0451c overlap by 4 nucleotidesRv0451c and Rv0452 are separated by 231 nucleotides Rv0450c: Rv0450c - Probable conserved transmembrane transport protein MmpL4, at 538,588 to 541,491 Rv0450c Rv0451c: Rv0451c - Probable conserved membrane protein MmpS4, at 541,488 to 541,910 Rv0451c Rv0452: Rv0452 - Possible transcriptional regulatory protein, at 542,142 to 542,852 Rv0452 Position (kb) 541 542Strain fitness (log2 ratio) -1 0 1 2at 540.513 kb on - strand, within Rv0450cat 540.597 kb on - strand, within Rv0450cat 540.605 kb on + strand, within Rv0450cat 540.605 kb on + strand, within Rv0450cat 540.606 kb on - strand, within Rv0450cat 540.609 kb on - strand, within Rv0450cat 540.674 kb on + strand, within Rv0450cat 540.675 kb on - strand, within Rv0450cat 540.748 kb on - strand, within Rv0450cat 540.900 kb on + strand, within Rv0450cat 541.510 kb on + strandat 541.644 kb on - strand, within Rv0451cat 541.801 kb on + strand, within Rv0451cat 541.905 kb on + strandat 541.906 kb on - strandat 541.906 kb on - strandat 541.906 kb on - strandat 541.995 kb on + strandat 541.995 kb on + strandat 542.009 kb on + strandat 542.038 kb on - strandat 542.038 kb on - strandat 542.059 kb on + strandat 542.059 kb on + strandat 542.060 kb on - strandat 542.079 kb on - strandat 542.107 kb on + strandat 542.107 kb on + strandat 542.107 kb on + strandat 542.107 kb on + strandat 542.107 kb on + strandat 542.107 kb on + strandat 542.107 kb on + strandat 542.108 kb on - strandat 542.399 kb on - strand, within Rv0452at 542.582 kb on - strand, within Rv0452at 542.658 kb on + strand, within Rv0452at 542.719 kb on - strand, within Rv0452

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Meropenem 9.6 ug/mL
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540,513 - Rv0450c 0.66 +1.6
540,597 - Rv0450c 0.69 -0.3
540,605 + Rv0450c 0.69 +0.6
540,605 + Rv0450c 0.69 +0.2
540,606 - Rv0450c 0.69 +0.4
540,609 - Rv0450c 0.70 +0.4
540,674 + Rv0450c 0.72 +0.0
540,675 - Rv0450c 0.72 +0.6
540,748 - Rv0450c 0.74 +0.2
540,900 + Rv0450c 0.80 +0.2
541,510 + +0.3
541,644 - Rv0451c 0.37 +1.5
541,801 + Rv0451c 0.74 -0.2
541,905 + +1.8
541,906 - +0.2
541,906 - +0.2
541,906 - +0.4
541,995 + +0.3
541,995 + +0.2
542,009 + -0.2
542,038 - -0.4
542,038 - +1.8
542,059 + +0.7
542,059 + +0.3
542,060 - -0.4
542,079 - -1.5
542,107 + +1.3
542,107 + +1.9
542,107 + +0.5
542,107 + +1.2
542,107 + +0.3
542,107 + +0.2
542,107 + +0.0
542,108 - +0.8
542,399 - Rv0452 0.36 -1.7
542,582 - Rv0452 0.62 -1.5
542,658 + Rv0452 0.73 -1.7
542,719 - Rv0452 0.81 -1.5

Or see this region's nucleotide sequence