Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0449c

Experiment: 7H9 with Meropenem 9.6 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0447c and Rv0448c overlap by 4 nucleotidesRv0448c and Rv0449c are separated by 59 nucleotidesRv0449c and Rv0450c are separated by 39 nucleotides Rv0447c: Rv0447c - Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (cyclopropane fatty acid synthase) (CFA synthase), at 535,224 to 536,507 Rv0447c Rv0448c: Rv0448c - Conserved hypothetical protein, at 536,504 to 537,169 Rv0448c Rv0449c: Rv0449c - Conserved hypothetical protein, at 537,229 to 538,548 Rv0449c Rv0450c: Rv0450c - Probable conserved transmembrane transport protein MmpL4, at 538,588 to 541,491 Rv0450c Position (kb) 537 538 539Strain fitness (log2 ratio) -1 0 1at 536.739 kb on - strand, within Rv0448cat 536.745 kb on + strand, within Rv0448cat 536.746 kb on - strand, within Rv0448cat 536.746 kb on - strand, within Rv0448cat 536.746 kb on - strand, within Rv0448cat 536.779 kb on - strand, within Rv0448cat 536.779 kb on - strand, within Rv0448cat 536.820 kb on - strand, within Rv0448cat 536.826 kb on + strand, within Rv0448cat 536.826 kb on + strand, within Rv0448cat 536.928 kb on + strand, within Rv0448cat 537.029 kb on - strand, within Rv0448cat 537.132 kb on + strandat 537.133 kb on - strandat 537.142 kb on - strandat 537.142 kb on - strandat 537.142 kb on - strandat 537.205 kb on - strandat 537.536 kb on + strand, within Rv0449cat 537.575 kb on + strand, within Rv0449cat 537.575 kb on + strand, within Rv0449cat 537.866 kb on + strand, within Rv0449cat 537.866 kb on + strand, within Rv0449cat 537.866 kb on + strand, within Rv0449cat 537.866 kb on + strand, within Rv0449cat 537.866 kb on + strand, within Rv0449cat 537.867 kb on - strand, within Rv0449cat 537.953 kb on + strand, within Rv0449cat 537.954 kb on - strand, within Rv0449cat 538.037 kb on + strand, within Rv0449cat 538.038 kb on - strand, within Rv0449cat 538.170 kb on - strand, within Rv0449cat 538.170 kb on - strand, within Rv0449cat 538.230 kb on - strand, within Rv0449cat 538.230 kb on - strand, within Rv0449cat 538.325 kb on + strand, within Rv0449cat 538.326 kb on - strand, within Rv0449cat 538.407 kb on - strand, within Rv0449cat 538.407 kb on - strand, within Rv0449cat 538.448 kb on + strandat 538.449 kb on - strandat 538.449 kb on - strandat 538.481 kb on + strandat 538.481 kb on + strandat 538.481 kb on + strandat 538.555 kb on + strandat 538.712 kb on - strandat 538.921 kb on + strand, within Rv0450cat 538.922 kb on - strand, within Rv0450cat 539.475 kb on + strand, within Rv0450c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Meropenem 9.6 ug/mL
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536,739 - Rv0448c 0.35 -0.0
536,745 + Rv0448c 0.36 -0.0
536,746 - Rv0448c 0.36 +0.5
536,746 - Rv0448c 0.36 -0.4
536,746 - Rv0448c 0.36 +0.2
536,779 - Rv0448c 0.41 -0.8
536,779 - Rv0448c 0.41 +0.7
536,820 - Rv0448c 0.47 +0.0
536,826 + Rv0448c 0.48 -0.0
536,826 + Rv0448c 0.48 -0.3
536,928 + Rv0448c 0.64 -1.6
537,029 - Rv0448c 0.79 -0.2
537,132 + -0.4
537,133 - -0.3
537,142 - -0.1
537,142 - -0.8
537,142 - +0.7
537,205 - -0.2
537,536 + Rv0449c 0.23 +0.3
537,575 + Rv0449c 0.26 -0.1
537,575 + Rv0449c 0.26 +0.0
537,866 + Rv0449c 0.48 +1.7
537,866 + Rv0449c 0.48 -0.0
537,866 + Rv0449c 0.48 -1.6
537,866 + Rv0449c 0.48 +0.6
537,866 + Rv0449c 0.48 +0.9
537,867 - Rv0449c 0.48 +0.1
537,953 + Rv0449c 0.55 +0.2
537,954 - Rv0449c 0.55 +0.1
538,037 + Rv0449c 0.61 -0.0
538,038 - Rv0449c 0.61 +1.0
538,170 - Rv0449c 0.71 -0.0
538,170 - Rv0449c 0.71 +0.0
538,230 - Rv0449c 0.76 -0.3
538,230 - Rv0449c 0.76 +1.0
538,325 + Rv0449c 0.83 -0.2
538,326 - Rv0449c 0.83 +0.9
538,407 - Rv0449c 0.89 +0.8
538,407 - Rv0449c 0.89 -0.2
538,448 + +0.3
538,449 - +1.2
538,449 - -0.1
538,481 + +0.2
538,481 + +0.2
538,481 + +0.0
538,555 + -0.0
538,712 - +0.2
538,921 + Rv0450c 0.11 -1.4
538,922 - Rv0450c 0.12 +0.3
539,475 + Rv0450c 0.31 +0.4

Or see this region's nucleotide sequence