Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0365c

Experiment: 7H9 with Meropenem 9.6 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0363c and Rv0364 are separated by 95 nucleotidesRv0364 and Rv0365c overlap by 12 nucleotidesRv0365c and Rv0366c are separated by 24 nucleotidesRv0366c and Rv0367c are separated by 28 nucleotides Rv0363c: Rv0363c - Probable fructose-bisphosphate aldolase Fba, at 441,265 to 442,299 Rv0363c Rv0364: Rv0364 - Possible conserved transmembrane protein, at 442,395 to 443,078 Rv0364 Rv0365c: Rv0365c - Conserved protein, at 443,067 to 444,197 Rv0365c Rv0366c: Rv0366c - Conserved hypothetical protein, at 444,222 to 444,815 Rv0366c Rv0367c: Rv0367c - Hypothetical protein, at 444,844 to 445,233 Rv0367c Position (kb) 443 444 445Strain fitness (log2 ratio) -1 0 1 2 3at 442.381 kb on + strandat 443.068 kb on + strandat 443.165 kb on + strandat 443.165 kb on + strandat 443.165 kb on + strandat 443.166 kb on - strandat 443.166 kb on - strandat 443.166 kb on - strandat 443.166 kb on - strandat 443.166 kb on - strandat 443.276 kb on - strand, within Rv0365cat 443.384 kb on - strand, within Rv0365cat 443.436 kb on + strand, within Rv0365cat 443.437 kb on - strand, within Rv0365cat 443.572 kb on + strand, within Rv0365cat 443.572 kb on + strand, within Rv0365cat 443.573 kb on - strand, within Rv0365cat 443.579 kb on - strand, within Rv0365cat 443.619 kb on + strand, within Rv0365cat 443.619 kb on + strand, within Rv0365cat 443.619 kb on + strand, within Rv0365cat 443.857 kb on - strand, within Rv0365cat 443.915 kb on - strand, within Rv0365cat 443.915 kb on - strand, within Rv0365cat 443.917 kb on + strand, within Rv0365cat 443.918 kb on - strand, within Rv0365cat 443.918 kb on - strand, within Rv0365cat 443.918 kb on - strand, within Rv0365cat 443.918 kb on - strand, within Rv0365cat 444.052 kb on + strand, within Rv0365cat 444.223 kb on + strandat 444.224 kb on - strandat 444.224 kb on - strandat 444.243 kb on - strandat 444.522 kb on + strand, within Rv0366cat 444.522 kb on + strand, within Rv0366cat 444.522 kb on + strand, within Rv0366cat 444.661 kb on + strand, within Rv0366cat 444.661 kb on + strand, within Rv0366cat 444.661 kb on + strand, within Rv0366cat 444.985 kb on - strand, within Rv0367c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Meropenem 9.6 ug/mL
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442,381 + -1.0
443,068 + -0.6
443,165 + -0.4
443,165 + -0.2
443,165 + -0.0
443,166 - +0.0
443,166 - +0.3
443,166 - +0.1
443,166 - -0.6
443,166 - +2.6
443,276 - Rv0365c 0.18 -0.1
443,384 - Rv0365c 0.28 -0.1
443,436 + Rv0365c 0.33 +0.8
443,437 - Rv0365c 0.33 -0.2
443,572 + Rv0365c 0.45 +0.3
443,572 + Rv0365c 0.45 +0.4
443,573 - Rv0365c 0.45 -0.0
443,579 - Rv0365c 0.45 -0.3
443,619 + Rv0365c 0.49 +0.3
443,619 + Rv0365c 0.49 +1.1
443,619 + Rv0365c 0.49 -0.5
443,857 - Rv0365c 0.70 -1.0
443,915 - Rv0365c 0.75 +0.2
443,915 - Rv0365c 0.75 +0.7
443,917 + Rv0365c 0.75 +3.5
443,918 - Rv0365c 0.75 -0.2
443,918 - Rv0365c 0.75 -0.4
443,918 - Rv0365c 0.75 -0.5
443,918 - Rv0365c 0.75 +0.0
444,052 + Rv0365c 0.87 +0.3
444,223 + +0.6
444,224 - -0.4
444,224 - +0.1
444,243 - -0.3
444,522 + Rv0366c 0.51 -0.1
444,522 + Rv0366c 0.51 -0.5
444,522 + Rv0366c 0.51 -0.4
444,661 + Rv0366c 0.74 -0.0
444,661 + Rv0366c 0.74 +0.0
444,661 + Rv0366c 0.74 +0.1
444,985 - Rv0367c 0.36 -0.6

Or see this region's nucleotide sequence