Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3330

Experiment: 7H9 with Meropenem 9.6 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3329 and Rv3330 are separated by 68 nucleotidesRv3330 and Rv3331 are separated by 95 nucleotides Rv3329: Rv3329 - Probable aminotransferase, at 3,714,392 to 3,715,708 Rv3329 Rv3330: Rv3330 - Probable penicillin-binding protein DacB1 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase), at 3,715,777 to 3,716,994 Rv3330 Rv3331: Rv3331 - Probable sugar-transport integral membrane protein SugI, at 3,717,090 to 3,718,598 Rv3331 Position (kb) 3715 3716 3717Strain fitness (log2 ratio) -1 0 1at 3715.079 kb on + strand, within Rv3329at 3715.160 kb on + strand, within Rv3329at 3715.415 kb on + strand, within Rv3329at 3715.539 kb on + strand, within Rv3329at 3715.568 kb on + strand, within Rv3329at 3715.568 kb on + strand, within Rv3329at 3715.568 kb on + strand, within Rv3329at 3715.569 kb on - strand, within Rv3329at 3715.844 kb on + strandat 3715.892 kb on - strandat 3715.968 kb on - strand, within Rv3330at 3716.263 kb on + strand, within Rv3330at 3716.263 kb on + strand, within Rv3330at 3716.264 kb on - strand, within Rv3330at 3716.264 kb on - strand, within Rv3330at 3716.264 kb on - strand, within Rv3330at 3716.264 kb on - strand, within Rv3330at 3716.264 kb on - strand, within Rv3330at 3716.458 kb on + strand, within Rv3330at 3716.458 kb on + strand, within Rv3330at 3716.594 kb on - strand, within Rv3330at 3716.594 kb on - strand, within Rv3330at 3716.600 kb on - strand, within Rv3330at 3716.630 kb on - strand, within Rv3330at 3716.631 kb on + strand, within Rv3330at 3716.632 kb on - strand, within Rv3330at 3716.632 kb on - strand, within Rv3330at 3716.759 kb on - strand, within Rv3330at 3716.992 kb on + strandat 3716.993 kb on - strandat 3716.993 kb on - strandat 3717.000 kb on + strandat 3717.288 kb on + strand, within Rv3331at 3717.582 kb on + strand, within Rv3331at 3717.582 kb on + strand, within Rv3331at 3717.583 kb on - strand, within Rv3331at 3717.681 kb on + strand, within Rv3331

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Meropenem 9.6 ug/mL
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3,715,079 + Rv3329 0.52 -0.1
3,715,160 + Rv3329 0.58 -0.3
3,715,415 + Rv3329 0.78 +0.1
3,715,539 + Rv3329 0.87 +0.2
3,715,568 + Rv3329 0.89 -0.4
3,715,568 + Rv3329 0.89 -0.6
3,715,568 + Rv3329 0.89 -0.9
3,715,569 - Rv3329 0.89 +0.5
3,715,844 + -1.1
3,715,892 - -0.9
3,715,968 - Rv3330 0.16 -0.5
3,716,263 + Rv3330 0.40 -1.3
3,716,263 + Rv3330 0.40 -0.5
3,716,264 - Rv3330 0.40 -0.3
3,716,264 - Rv3330 0.40 -0.2
3,716,264 - Rv3330 0.40 -1.0
3,716,264 - Rv3330 0.40 +0.7
3,716,264 - Rv3330 0.40 -1.0
3,716,458 + Rv3330 0.56 +1.1
3,716,458 + Rv3330 0.56 -0.9
3,716,594 - Rv3330 0.67 -1.0
3,716,594 - Rv3330 0.67 -0.7
3,716,600 - Rv3330 0.68 +0.8
3,716,630 - Rv3330 0.70 -0.6
3,716,631 + Rv3330 0.70 -1.0
3,716,632 - Rv3330 0.70 -1.0
3,716,632 - Rv3330 0.70 -0.8
3,716,759 - Rv3330 0.81 +1.1
3,716,992 + -0.6
3,716,993 - +0.5
3,716,993 - +0.0
3,717,000 + -1.0
3,717,288 + Rv3331 0.13 -0.5
3,717,582 + Rv3331 0.33 +1.4
3,717,582 + Rv3331 0.33 +0.4
3,717,583 - Rv3331 0.33 -0.3
3,717,681 + Rv3331 0.39 +0.1

Or see this region's nucleotide sequence