Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2163c

Experiment: 7H9 with Meropenem 9.6 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2162c and Rv2163c are separated by 209 nucleotidesRv2163c and Rv2164c overlap by 4 nucleotides Rv2162c: Rv2162c - PE-PGRS family protein PE_PGRS38, at 2,423,240 to 2,424,838 Rv2162c Rv2163c: Rv2163c - Probable penicillin-binding membrane protein PbpB, at 2,425,048 to 2,427,087 Rv2163c Rv2164c: Rv2164c - Probable conserved proline rich membrane protein, at 2,427,084 to 2,428,238 Rv2164c Position (kb) 2425 2426 2427 2428Strain fitness (log2 ratio) -1 0 1at 2424.285 kb on + strand, within Rv2162cat 2424.286 kb on - strand, within Rv2162cat 2424.422 kb on - strand, within Rv2162cat 2424.435 kb on + strand, within Rv2162cat 2424.625 kb on - strand, within Rv2162cat 2424.655 kb on - strand, within Rv2162cat 2424.655 kb on - strand, within Rv2162cat 2424.913 kb on + strandat 2425.050 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Meropenem 9.6 ug/mL
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2,424,285 + Rv2162c 0.65 +0.0
2,424,286 - Rv2162c 0.65 +0.0
2,424,422 - Rv2162c 0.74 -0.0
2,424,435 + Rv2162c 0.75 +0.3
2,424,625 - Rv2162c 0.87 -0.3
2,424,655 - Rv2162c 0.88 +0.7
2,424,655 - Rv2162c 0.88 -0.4
2,424,913 + -0.2
2,425,050 - -0.8

Or see this region's nucleotide sequence